Results 71 to 80 of about 1,221,708 (301)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Active Electromagnetic Clutch for Crankshaft Decoupling from a Belt Drive System

open access: yesApplied Sciences
This work presents a novel electromagnetic clutch installed on the crankshaft pulley to decouple the internal combustion engine from the front-end accessory drive of a P0 hybrid electric vehicle. The objective is to supply the air conditioning compressor
Luis M. Castellanos Molina   +6 more
doaj   +1 more source

The import of used cars to Poland after EU accession

open access: yesPrace Komisji Geografii Przemysłu Polskiego Towarzystwa Geograficznego, 2020
The purpose of the article is to identify the volume and spatial structure of imports of used cars to Poland during the first 15 years of membership in the European Union, using data from the Central Re gister of Vehicles.
doaj   +1 more source

Covariate-assisted ranking and screening for large-scale two-sample inference [PDF]

open access: yes, 2019
Two-sample multiple testing has a wide range of applications. The conventionalpractice first reduces the original observations to a vector of p-values and then chooses a cutoffto adjust for multiplicity.
Cai, T. Tony   +2 more
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

ANOVA în cercetrările de marketing [PDF]

open access: yes
In order to make an analysis of the variation regarding ANOVA, we considered the commercial society S.C. RUCOM S.A. from Craiova, Dolj, 107 Caracal Street, dealer in the sale of cars mark Opel, even from 2002. Starting with 2004, S.C. RUCOM S.A.
Tomescu Dumitrescu, C.
core   +1 more source

Parking cars of different sizes

open access: yes, 2016
We extend the notion of parking functions to parking sequences, which include cars of different sizes, and prove a product formula for the number of such sequences.Comment: 5 pages, 5 ...
Ehrenborg, Richard, Happ, Alex
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

End to End Performance Analysis of Relay Cooperative Communication Based on Parked Cars

open access: yes, 2018
Parking lots (PLs) are usually full with cars. If these cars are formed into a self-organizing vehicular network, they can be new kind of road side units (RSUs) in urban area to provide communication data forwarding between mobile terminals nearby and a ...
Bai, Zhiquan   +5 more
core   +1 more source

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