Results 21 to 30 of about 115,107 (269)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
GeosciencesAs a typical porous medium, unsaturated loess demonstrates critical hydro-mechanical coupling properties that fundamentally influence geohazard mitigation, groundwater resource evaluation, and foundation stability in geotechnical engineering.
Hu Zeng +4 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Applied SciencesTo address the technical challenges in dynamic monitoring of grout diffusion patterns under complex geological conditions, in this study, a distributed parallel grouting monitoring system based on electrical resistivity tomography was developed.
Hu Zeng +4 more
doaj +1 more source
(S)cars: Exploring America's Automotive Self
Review of International American Studies, 2021 The article opens with an autoethnographic account of its author's encounter with the American sense of space in the context of the clash of his own and American cultural norms related to car ownership and car use.
Paweł Jędrzejko
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Chengshi guidao jiaotong yanjiu［Objective］ In the context of the current urban rail transit towards intelligent，green and low-carbon development, upgrading the traction power supply system, the "heart" of urban rail transit, is of crucial importance for realizing the green and smart ...
HU Ji, LING Chen, SU Jingqi, LIU Shuo
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
American Journal of Hematology, 2019 CAR T cells have revolutionized the treatment of relapsed and refractory CD19‐positive leukemia and lymphoma. Unfortunately, the majority of patients treated will not achieve durable remissions. Reasons for these suboptimal clinical outcomes can be tied back to intrinsic CAR T cell design and manufacturing processes, factors that are highly amenable to
Anthony F, Daniyan, Renier J, Brentjens
openaire +2 more sources