Results 171 to 180 of about 10,114 (290)

Political constraints on government cartelization: the case of oil production regulation in Texas and Saudi Arabia. [PDF]

We examine government cartelization efforts in crude oil production. Texas and Saudi Arabia are alleged to act as swing producers to maintain the interstate (1933-1972) and OPEC (1973 on) oil cartels respectively.
James L. Smith, Gary Libecap
core  

Emergence of synthetic drugs in South America: insights from Brazil, Chile, and Colombia. [PDF]

Harm Reduct J
Bórquez I, Pantaleão B, Brogim G, da Cunha AP, Krawczyk N, Bastos FI.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

What happens next: The lingering effects of child abuse in a Mexican cohort. [PDF]

Sao Paulo Med J
Martínez ER, Aceves MR, Balderas AB, Gutiérrez AAC, Pulido EEC, Picazo DM.   +5 more
europepmc   +1 more source

The Hirsch-index in self-citation rates with articles in Medicine (Baltimore): Bibliometric analysis of publications in two stages from 2018 to 2021. [PDF]

Medicine (Baltimore), 2022
Liu MY, Chien TW, Chou W.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Artificial Intelligence as a Safeguard for Clinical Scientific Integrity: A Human-AI Hybrid Model for Medical Peer Review. [PDF]

J Clin Med
Dore MP, Merola E, Lasaracina G, Pes GM.
europepmc   +1 more source

Reports of rising use of fentanyl in contemporary Brazil is of concern, but a US-like crisis may still be averted. [PDF]

Lancet Reg Health Am, 2023
Bastos FI, Krawczyk N.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The rise and fall of carfentanil in Toronto's unregulated drug supply. [PDF]

Lancet Reg Health Am
Karamouzian M.
europepmc   +1 more source