Results 121 to 130 of about 278,892 (274)

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen

Advanced Science, EarlyView.
This study defines the structure, mechanics, and mechanobiology of the fibrocartilage pericellular matrix (PCM) using the murine meniscus, showing how collagen V deficiency alters PCM properties and disrupts cell mechanosensitive signaling. Findings emphasize the critical role of PCM in fibrocartilage mechanobiology and suggest targeting it can enhance
Chao Wang, Mingyue Fan, Su Chin Heo, Sheila M. Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Jason A. Burdick, X. Lucas Lu, David E. Birk, Farid Alisafaei, Robert L. Mauck, Lin Han   +13 more
wiley   +1 more source

Costal Cartilage Segmentation with Topology Guided Deformable Mamba: Method and Benchmark [PDF]

arXiv
Costal cartilage segmentation is crucial to various medical applications, necessitating precise and reliable techniques due to its complex anatomy and the importance of accurate diagnosis and surgical planning. We propose a novel deep learning-based approach called topology-guided deformable Mamba (TGDM) for costal cartilage segmentation.
arxiv  

Congenital Discoid Internal Cartilage [PDF]

, 1945
F. C. Dwyer, Carolyn E. Taylor
openalex   +1 more source

PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis

Advanced Science, EarlyView.
Glucocorticoid‐induced osteoporosis (GIOP) triggers osteocyte ferroptosis via SLC7A11 degradation. PSMD14 stabilizes SLC7A11 by counteracting glucocorticoid‐driven ubiquitination, preserving cystine uptake and glutathione synthesis. AAV‐mediated PSMD14 delivery or its agonist Pantethine rescues osteocyte survival and bone loss in GIOP mice.
Yifeng Shi, Qian Tang, Sunren Sheng, Hongyi Jiang, Chen Jin, Chencheng Zhou, Chenglong Xie, Lin Zheng, Di Zhang, Hui Xu, Cong Xu, Haiwei Ma, Guangheng Xiang, Wenfei Ni, Xiaoyun Pan, Lei Yang, Huazi Xu, Yu Qian, Aimin Wu, Xiangyang Wang, Gang Zheng   +20 more
wiley   +1 more source

Histochemical Studies of Rheumatic Conditions: I. Observations on the Fine Structures of the Matrix of Normal Bone and Cartilage

, 1953
H. T. Fawns, J. W. Landells
openalex   +1 more source

THE INHIBITION OF TRYPTIC DIGESTION OF CARTILAGE BY SYNOVIAL FLUID FROM PATIENTS WITH VARIOUS TYPES OF ARTHRITIS 1 [PDF]

, 1935
Chester S. Keefer, William F. Holmes, Walter K. Myers   +2 more
openalex   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Corrigendum: NF-κB/TWIST1 Mediates Migration and Phagocytosis of Macrophages in the Mice Model of Implant-Associated Staphylococcus aureus Osteomyelitis

Frontiers in Microbiology, 2020
Yutian Wang, Yutian Wang, Yihuang Lin, Yihuang Lin, Caiyu Cheng, Caiyu Cheng, Pengyu Chen, Pengyu Chen, Ping Zhang, Hangtian Wu, Hangtian Wu, Kaiqun Li, Kaiqun Li, Ye Deng, Ye Deng, Jikun Qian, Jikun Qian, Xianrong Zhang, Xianrong Zhang, Bin Yu, Bin Yu   +20 more
doaj   +1 more source

Quantifying Knee Cartilage Shape and Lesion: From Image to Metrics [PDF]

arXiv
Imaging features of knee articular cartilage have been shown to be potential imaging biomarkers for knee osteoarthritis. Despite recent methodological advancements in image analysis techniques like image segmentation, registration, and domain-specific image computing algorithms, only a few works focus on building fully automated pipelines for imaging ...
arxiv  

In Vitro Study of Cartilage Induction in T/TMice [PDF]

, 1958
Dorothea Bennett
openalex   +1 more source