Results 121 to 130 of about 215,224 (198)

Compression suture: A method for simulating intervertebral disc degeneration in rats induced by excessive loading

Animal Models and Experimental Medicine, EarlyView.
In the compression suture group, a 5‐mm‐wide tail skin was removed, and then the defect was sutured to apply compressive force to the intervertebral disc. In the sham group, only the 5‐mm‐wide tail skin was removed without a compression suture. Compression suturing triggers apoptosis, inflammatory response, and imbalance of extracellular matrix ...
Xuening Liu, Fengguang Yang, Hefang Xiao, Yanni Duan, Xuewen Kang   +4 more
wiley   +1 more source

Trinuclear Heptamethine Dyes for Shortwave Infrared In Vivo Imaging

Angewandte Chemie, EarlyView.
The reactivity of cyclopentenyl‐bridged polymethine dyes is leveraged to synthesize shortwave infrared (SWIR)‐emissive di‐ and trinuclear polymethine dyes. Chromenylium‐ and flavylium‐based trinuclear dyes demonstrate increased nucleophilic stability, minimal aggregation in micelle formulations, and notable lymph node accumulation.
Cesar A. Garcia, Eric Y. Lin, Emily B. Mobley, Allen Louie, Kaitlin M. Hartung, Jesus A. Araujo, Ellen M. Sletten   +6 more
wiley   +2 more sources

Critical role of Sirtuin 6 (SIRT6) in osteoarthritis chondrocytes: the interaction among various biological processes. [PDF]

Ann Med
Ding N, He Z, Yang Q.
europepmc   +1 more source

Correlations Between Osteocyte Lacuno‐Canalicular Network and Material Characteristics in Healthy and Mechanically Stimulated Murine Tibiae

Advanced NanoBiomed Research, EarlyView.
This article reveals how calcium content, mineral nanostructure, and lacuno‐canalicular network (LCN) organization interact to shape bone heterogeneity in mouse tibiae. Advanced multimodal imaging uncovers that mechanical loading promotes mature mineral structures even in low‐calcium regions, highlighting LCN‐driven mineralization and offering new ...
Victoria Schemenz, Maximilian Rummler, Alexander van Tol, Isabela Vitienes, Tobias Thiele, Markus A. Hartmann, Manfred Burghammer, Peter Fratzl, Richard Weinkamer, Bettina M. Willie, Wolfgang Wagermaier   +10 more
wiley   +1 more source

Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network. [PDF]

Bone Res
Ruiz-Hernández R, Gay L, Moncho-Amor V, Martín P, Vergara-Arce JA, Di Blasio S, Snoeks T, Cossío U, Matheu A, Caffarel MM, Gerovska D, Araúzo-Bravo MJ, Vilas A, Prosper F, Moya S, Alonso-Alconada D, Alonso-Varona A, Nusspaumer G, Lopez-Rios J, Rizotti K, Lovell-Badge R, Bonnet D, Malanchi I, Abarrategi A.   +23 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Analysis of cartilage creep-recovery of human osteoarthritic cartilage. [PDF]

Eur J Med Res
Stolberg-Stolberg J, Löscher I, Charitou F, Huelskamp MD, Lang JJ, Köppe J, Lazic I, Tübel J, Burgkart R.   +8 more
europepmc   +1 more source

Multimaterial Triphasic Scaffold Replicates Enthesis Microenvironment to Modulate Early Cell Responses

Advanced NanoBiomed Research, EarlyView.
A bioinspired triphasic scaffold integrating 3D printed polycaprolactone and electrospun poly(lactic‐co‐glycolic acid) is developed to replicate the organization of the tendon‐to‐bone enthesis. Cyclic mechanical stimulation induces spatially defined cell morphology and lineage‐related gene expression in human mesenchymal stem cells, highlighting the ...
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni Vozzi   +7 more
wiley   +1 more source

Effects of Mechanical Stress on Bone and Cartilage Metabolism: How Mechanical Stress Affects Energy Metabolism in Bone and Cartilage Tissues (Our Research Overview): Mini Review. [PDF]

Int J Mol Sci
Iwata H, Sato S, Somemura S, Takemoto M, Takahashi-Suzuki Y, Sugishita Y, Fujiya H, Haraguchi N, Yudoh K.   +8 more
europepmc   +1 more source