Results 61 to 70 of about 482,923 (307)

Apolipoprotein E deficiency potentiates macrophage against Staphylococcus aureus in mice with osteomyelitis via regulating cholesterol metabolism

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionStaphylococcus aureus (S. aureus) osteomyelitis causes a variety of metabolism disorders in microenvironment and cells. Defining the changes in cholesterol metabolism and identifying key factors involved in cholesterol metabolism disorders ...
Mincheng Lu, Mincheng Lu, Ruiyi He, Ruiyi He, Chao Li, Chao Li, Zixian Liu, Zixian Liu, Yuhui Chen, Yuhui Chen, Bingsheng Yang, Bingsheng Yang, Xianrong Zhang, Xianrong Zhang, Bin Yu, Bin Yu   +15 more
doaj   +1 more source

Performance Characteristics of Anti–Collagen II Antibodies in Relapsing Polychondritis and Related Diseases: Prospective Analysis, Systematic Review, and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Relapsing polychondritis (RP) is a rare disease defined by recurrent cartilaginous inflammation. Anti–collagen II (Col2) antibodies have been proposed as a diagnostic biomarker for RP, but their performance characteristics are not well defined.
Karyssa Stonick, Marcela A. Ferrada, Alice Fike, Kaitlin A. Quinn, Benjamin A. Turturice, Casey Stein, Peter C Grayson   +6 more
wiley   +1 more source

Biomimetic sulphated alginate hydrogels suppress IL-1β-induced inflammatory responses in human chondrocytes [PDF]

European Cells & Materials, 2017
Loss of articular cartilage from ageing, injury or degenerative disease is commonly associated with inflammation, causing pain and accelerating degradation of the cartilage matrix.
Ø Arlov, E Öztürk, M Steinwachs, G Skjåk-Bræk, M Zenobi-Wong   +4 more
doaj   +1 more source

Cartilage‐on‐cartilage versus metal‐on‐cartilage impact characteristics and responses [PDF]

Journal of Orthopaedic Research, 2013
AbstractA common in vitro model for studying acute mechanical damage in cartilage is to impact an isolated osteochondral or cartilage specimen with a metallic impactor. The mechanics of a cartilage‐on‐cartilage (COC) impact, as encountered in vivo, are likely different than those of a metal‐on‐cartilage (MOC) impact.
Anneliese D, Heiner, Abigail D, Smith, Jessica E, Goetz, Curtis M, Goreham-Voss, Kyle T, Judd, Todd O, McKinley, James A, Martin   +6 more
openaire   +2 more sources

Associations of Sleep and Shift Work With Osteoarthritis Risk

Arthritis Care &Research, EarlyView.
Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik, Abigail Bridgeman, Erik D. Herzog, Vy Pham, Bradley A. Evanoff, Farshid Guilak   +5 more
wiley   +1 more source

Quantitative geometric analysis of rib, costal cartilage and sternum from childhood to teenagehood [PDF]

, 2013
Better understanding of the effects of growth on children’s bones and cartilage is necessary for clinical and biomechanical purposes. The aim of this study is to define the 3D geometry of children’s rib cages: including sternum, ribs and costal cartilage.
BADINA, Alina, LAMBOT, Karene, LAPORTE, Sébastien, MITTON, David, SANDOZ, Baptiste, SKALLI, Wafa   +5 more
core   +4 more sources

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

A New Technique for Distalization of the Tibial Tubercle That Allows Preservation of the Proximal Buttress

Orthopaedic Journal of Sports Medicine, 2018
Background: Tibial tubercle osteotomy (TTO) is a treatment option for patients with patellofemoral instability and chondrosis. Occasionally, these patients also present with patella alta, and distalization of the tibial tubercle is desirable. Free distal
Luiz Felipe Ambra MD, PhD, Amy Phan BS, Andreas H. Gomoll MD   +2 more
doaj   +1 more source

High efficiency transfection of embryonic limb mesenchyme with plasmid DNA using square wave pulse electroporation and sucrose buffer

BioTechniques, 2014
Micromass cultures of primary embryonic limb mesenchyme are a valuable model system for studying cartilage formation in vitro. However, high efficiency introduction of plasmid DNA into this hard-to-transfect cell type typically results in considerable ...
Brent E. Bobick, Peter G. Alexander, Rocky S. Tuan   +2 more
doaj   +1 more source

Vitamin D Receptor Genetic Polymorphisms Associate With a Decreased Susceptibility to Extremity Osteomyelitis Partly by Inhibiting Macrophage Apoptosis Through Inhibition of Excessive ROS Production via VDR-Bmi1 Signaling

Frontiers in Physiology, 2022
Background: Previous studies had reported that vitamin D receptor (VDR) gene polymorphisms were related to the development of several inflammatory disorders. However, potential links between such variations and the risk of developing a bone infection and
Xing-Qi Zhao, Xing-Qi Zhao, Hao-Yang Wan, Hao-Yang Wan, Si-Ying He, Si-Ying He, Han-Jun Qin, Han-Jun Qin, Bin Yu, Bin Yu, Nan Jiang, Nan Jiang   +11 more
doaj   +1 more source