Results 101 to 110 of about 136,745 (341)

Intra-articular injection of ascorbic acid enhances microfracture-mediated cartilage repair

Scientific Reports
Previous studies have confirmed that ascorbic acid (AA) can promote cartilage repair and improve cartilage differentiation in bone marrow mesenchymal stem cells.
Zhian Chen, Sihe Zhang, Peiya Duan, Zhengbo Yin, Shuangbin Dong, Rongqing Pang, Hongbo Tan   +6 more
doaj   +1 more source

Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures

Stem Cells International, 2018
Due to the restricted intrinsic capacity of resident chondrocytes to regenerate the lost cartilage postinjury, stem cell-based therapies have been proposed as a novel therapeutic approach for cartilage repair.
Melissa Lo Monaco, Greet Merckx, Jessica Ratajczak, Pascal Gervois, Petra Hilkens, Peter Clegg, Annelies Bronckaers, Jean-Michel Vandeweerd, Ivo Lambrichts   +8 more
doaj   +1 more source

Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back, Moonkyoung Jeong, Huyen‐Thao Le, Ji‐Ho Park   +3 more
wiley   +1 more source

Comparative Effectiveness of Structural versus Regulatory Protein Gene Transfer on Articular Chondrocyte Matrix Gene Expression [PDF]

, 2019
OBJECTIVE: The production of extracellular matrix is a necessary component of articular cartilage repair. Gene transfer is a promising method to improve matrix biosynthesis by articular chondrocytes.
Chan, Albert, Eckert, George J., Kirmani, Kashif, Shi, Shuiliang, Trippel, Stephen B., Wang, Congrong   +5 more
core   +1 more source

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source

Structured Light Projection Using Image Guide Fibers for In Situ Photo‐biofabrication

Advanced Materials, EarlyView.
Light‐based biofabrication is typically performed with single wavelength light sources and within benchtop devices. This work demonstrates FaSt‐Light (Fiber‐assisted Structured Light) as a new approach to achieve multiwavelength image projection using flexible image guide fibers, which enables a variety of applications for in situ biofabrication ...
Parth Chansoria, Michael Winkelbauer, Shipin Zhang, Jakub Janiak, Hao Liu, Dimitar Boev, Andrea Morandi, Rachel Grange, Marcy Zenobi‐Wong   +8 more
wiley   +1 more source

Bridging Suture Repair for Acetabular Chondral Carpet Delamination

Arthroscopy Techniques, 2015
Acetabular chondral carpet delamination is a frequent finding at hip arthroscopy. The cartilage is macroscopically normal but deboned from the subchondral bone, without a disruption at the chondrolabral junction.
Mitsunori Kaya, M.D., Toshiaki Hirose, M.D., Toshihiko Yamashita, M.D.   +2 more
doaj  

NGF-BMSC-SF/CS composites for repairing knee joint osteochondral defects in rabbits: evaluation of the repair effect and potential underlying mechanisms

Journal of Orthopaedic Surgery and Research
Background With the rapid growth of the ageing population, chronic diseases such as osteoarthritis have become one of the major diseases affecting the quality of life of elderly people.
Yong Zhang, Wenliang Huang, Hongli Xiao, Shiqiang Ruan, Jiang Deng   +4 more
doaj   +1 more source

The effect of diabetes on fracture repair : alterations in angiogenesis and apoptosis [PDF]

, 2007
Thesis (MSD)--Boston University, Goldman School of Dental Medicine, 2007 (Endodontics).Includes bibliographical references: leaves 56-65.An abundance of evidence has emerged demonstrating a close link between diabetes and significantly impaired fracture ...
Bollman, Megan
core  

Chondrocyte outgrowth into a gelatin scaffold in a single impact load model of damage/repair - effect of BMP-2. [PDF]

, 2011
BACKGROUND: Articular cartilage has little capacity for repair in vivo, however, a small number of studies have shown that, in vitro, a damage/repair response can be induced.
Henson, Frances MD, Vincent, Thea
core   +1 more source