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Orthopedic Clinics of North America, 2023
Osteochondral lesions of the ankle joint are typically associated with a traumatic etiology and present with ankle pain and swelling. Conservative management yields unsatisfactory results because of the poor healing capacity of the articular cartilage. Smaller lesions (10 mm), cystic lesions, uncontained lesions, or patients who have failed prior bone ...
Mohammad T, Azam +6 more
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Osteochondral lesions of the ankle joint are typically associated with a traumatic etiology and present with ankle pain and swelling. Conservative management yields unsatisfactory results because of the poor healing capacity of the articular cartilage. Smaller lesions (10 mm), cystic lesions, uncontained lesions, or patients who have failed prior bone ...
Mohammad T, Azam +6 more
openaire +2 more sources
Cartilage Tissue and Therapeutic Strategies for Cartilage Repair
Current Molecular Medicine, 2021: High incidence of articular cartilage defects is still a major challenge in orthopedic and trauma surgery worldwide. It also has great socioeconomic effects as it is the major cause of disability in industrialized countries. This highlights the essential need for new treatments.
Sahar Khajeh +4 more
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Physical Medicine and Rehabilitation Clinics of North America, 2000
Articular cartilage is a complex structure that, once damaged, has little capacity for permanent repair. The problem lies in the inability of the body to regenerate tissue with the appropriate macromolecular constituents and architecture of normal hyaline cartilage.
Christopher H. Evans +3 more
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Articular cartilage is a complex structure that, once damaged, has little capacity for permanent repair. The problem lies in the inability of the body to regenerate tissue with the appropriate macromolecular constituents and architecture of normal hyaline cartilage.
Christopher H. Evans +3 more
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Clinical Orthopaedics and Related Research, 2001
Techniques for repairing focal articular cartilage defects are evolving from methods that induce a local stimulation of fibrocartilaginous repair to methods that will lead to a hyaline articular cartilage repair. Mosaicplasty and autologous chondrocyte implantation are examples of the latter.
Robert L. Sah +5 more
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Techniques for repairing focal articular cartilage defects are evolving from methods that induce a local stimulation of fibrocartilaginous repair to methods that will lead to a hyaline articular cartilage repair. Mosaicplasty and autologous chondrocyte implantation are examples of the latter.
Robert L. Sah +5 more
openaire +3 more sources
Proteoglycans and Cartilage Repair
2011Repair of damaged articular cartilage in osteoarthritis (OA) is a clinical challenge. Because cartilage is an avascular and aneural tissue, normal mechanisms of tissue repair through recruitment of cells to the site of tissue destruction are not feasible.
Sylvie Fournel-Gigleux +2 more
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Growth Factors and Cartilage Repair
Clinical Orthopaedics and Related Research, 2001Growth factors are obvious tools to enhance cartilage repair. Understanding of reactivities in normal and arthritic cartilage and potential side effects on other compartments in the joint will help to identify possibilities and limitations. Growth factor responses have been evaluated in normal and diseased murine knees.
Berg, W.B. van den +3 more
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The American Journal of Sports Medicine, 1998
Articular cartilage can tolerate a tremendous amount of intensive and repetitive physical stress. However, it manifests a striking inability to heal even the most minor injury. Both the remarkable functional characteristics and the healing limitations reflect the intricacies of its structure and biology.
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Articular cartilage can tolerate a tremendous amount of intensive and repetitive physical stress. However, it manifests a striking inability to heal even the most minor injury. Both the remarkable functional characteristics and the healing limitations reflect the intricacies of its structure and biology.
openaire +3 more sources
Decellularized cartilage as a prospective scaffold for cartilage repair
Materials Science and Engineering: C, 2019Articular cartilage lacks self-healing capacity, and there is no effective therapy facilitating cartilage repair. Osteoarthritis (OA) due to cartilage defects represents large and increasing healthcare burdens worldwide. Nowadays, the generation of scaffolds to preserve bioactive factors and the biophysical environment has received increasing attention.
Chen Xia +10 more
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Foot and Ankle Clinics, 2003
The cause of a typical osteochondral lesion of the talus is traumatic; if symptomatic, several options exist. Because nonoperative treatment results in no more than 50% good to excellent results, the following types of surgery are in clinical use: (1) debridement and drilling, (2) osteochondral transfer, and (3) autologous chondrocyte transplantation ...
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The cause of a typical osteochondral lesion of the talus is traumatic; if symptomatic, several options exist. Because nonoperative treatment results in no more than 50% good to excellent results, the following types of surgery are in clinical use: (1) debridement and drilling, (2) osteochondral transfer, and (3) autologous chondrocyte transplantation ...
openaire +3 more sources
Scaffolds for Cartilage Repair
2021Scaffolds are becoming increasingly recognized as an option in the treatment of chondral and osteochondral defects in the knee. They are made from biocompatible materials that can mimic the osteochondral unit in the knee. The advantages include one-stage surgery with good short-term clinical results.
Daniele Altomare +4 more
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