Results 41 to 50 of about 87,710 (243)
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Discussion approach of a political caricature
Amauta, 2017 This article presents the discourse analysis of a political cartoon, created by Vladdo (2011) and published in Semana magazine. It contains three sections.
Efraín Morales Escorcia +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Political cartoon as a genre of political discourse
RUDN Journal of Language Studies, Semiotics and Semantics, 2018 The article is devoted to the consideration of the modern political cartoons on foreign policy and socially-significant topics in Arabic and French. Political cartoon is a genre of political discourse that entered the scope of linguistic problems in the ...
Natalia M Dugalich
doaj +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Din ve Değerler Eğitimi Açısından 'Tay' Animasyon Sinema Filminin İncelemesi
İlahiyat Akademi, 2022 Günümüzde günlük hayatımızın vazgeçilmez bir parçası haline gelen bilgisayar, internet gibi görsel iletişim araçları eğitim ve öğretimi daha anlamlı ve kalıcı kılmak açısından oldukça önemlidir.
Rabia Yıldırım
doaj +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Harmonia: Journal of Arts Research and Education, 2016 A comic cartoon is a communication media that is widely enjoyed and accepted by people. As a literary and journalistic work, the comic cartoon also captures the surrounding cultural situation.
Abdullah Ibnu Thalhah
doaj +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Estimating reflectance and shape of objects from a single cartoon-shaded image
Computational Visual Media, 2017 Although many photorealistic relighting methods provide a way to change the illumination of objects in a digital photograph, it is currently difficult to relight digital illustrations having a cartoon shading style.
Hideki Todo, Yasushi Yamaguchi
doaj +1 more source