Results 191 to 200 of about 45,815 (295)

Designing Thermally Stable DNA Hydrogels via Entropically‐Driven Acridine Intercalation

open access: yesMacromolecular Rapid Communications, EarlyView.
Environmental variables are shown to systematically tune the network dynamics of entropy‐driven, acridine‐based DNA‐intercalating supramolecular hydrogels. Adjusting the buffer composition, ionic identity, and salt concentration impacts electrostatic screening and counterion release of the DNA backbone, offering a powerful handle to tune elasticity and
Shaina M. Hughes   +5 more
wiley   +1 more source

Neurodevelopmental Disorder with Dystonia and Chorea Linked to De Novo Variants in the Splicing Regulator SRRM4

open access: yesMovement Disorders, EarlyView.
Abstract Background SRRM4 is an exclusively neural‐expressed splicing‐factor gene not yet associated with a monogenic condition. Objective We sought to delineate movement disorders caused by SRRM4 variants. De novo splice‐donor‐site variants at position +2 of intron 5 of SRRM4 (c.464+2T>C, c.464+2T>A) occurred in three unrelated patients with dystonia ...
Philip Harrer   +24 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood   +7 more
wiley   +1 more source

Cartoon [PDF]

open access: yesUltrasound in Obstetrics & Gynecology, 2007
openaire   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors. [PDF]

open access: yesAdv Sci (Weinh)
Su H   +15 more
europepmc   +1 more source

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