Results 91 to 100 of about 38,527 (248)

Results of the ACCOuNT Trial: A Multi‐Institutional Prospective Pharmacogenomics Implementation Trial for African American Inpatients

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 109-119, January 2026.
Pharmacogenomics implementation efforts have increased over the last decade, but no published prospective pharmacogenomics trials have formally evaluated utility in underrepresented populations. We present final results from the ACCOuNT trial, a multi‐institutional prospective study [NCT03225820] in which African American inpatients were genotyped and ...
Zhong Huang, Kevin J. O’Leary, Edith A. Nutescu, Matthew Jack, Thomas Chen, Gregory W. Ruhnke, James C. Lee, David George, Larry K. House, Randall Knoebel, Luke V. Rasmussen, Seth Hartman, Anish Choksi, Kiang‐Teck J. Yeo, Minoli A. Perera, Mark J. Ratain, David O. Meltzer, Peter H. O’Donnell   +17 more
wiley   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Endothelial function is unaffected by changing between carvedilol and metoprolol in patients with heart failure-a randomized study

Cardiovascular Diabetology, 2011
Background Carvedilol has been shown to be superior to metoprolol tartrate to improve clinical outcomes in patients with heart failure (HF), yet the mechanisms responsible for these differences remain unclear.
Køber Lars, Major-Pedersen Atheline, Rask-Madsen Christian, Christiansen Buris, Raunsø Jakob, Hermann Thomas, Falskov Britt, Torp-Pedersen Christian, Dominguez Helena   +8 more
doaj   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

The Combined Effects of an Anti‐Inflammatory Diet and Curcumin Supplementation on Thyroid Function and Lipid Profile in Patients With Hashimoto's Thyroiditis: A Double Blind Randomised Clinical Trial

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
Anti‐TPO levels, along with waist circumference and waist‐to‐hip ratio, showed notable reductions in the curcumin group compared to placebo, while other thyroid‐related and metabolic markers remained largely unchanged. ABSTRACT Background Hashimoto's thyroiditis (HT) is an inflammatory autoimmune disease and patients with HT may benefit from ...
Fatemeh Bourbour, Behnam Mahdavi, Niayesh Naghshi, Zahra Yari, Seyedsina Moghimnejad hosseini, Saeid Kalbasi, Golbon Sohrab   +6 more
wiley   +1 more source

Nano and Microparticulate Chitosan Based System for Formulation of Carvedilol Rapid Melt Tablet

Advanced Pharmaceutical Bulletin, 2015
Purpose: In the present study rapid melt tablets (RMT’s) of carvedilol were prepared by using ionotropic-gelated chitosan nanoparticles using a spray-drying method.
Ravindra Patil, Vishal Pande, Raju Sonawane   +2 more
doaj   +1 more source

A carvedilolterápia előnyei magas cardiovascularis kockázatú betegek kezelése során [PDF]

, 2016
Absztrakt A kardiológiai gyógyszeres terápia eszköztárában a béta-blokkolók kiemelkedő helyen szerepelnek. Ennek több oka van. Egyrészt számos indikációs körrel rendelkeznek, annak ellenére, hogy a
Fi, Zsolt, Szentes, Veronika
core   +1 more source

Edible Seeds in the Fight Against Hypertension: A Review of In Vitro, In Vivo, and Clinical Evidences With a Mechanistic Insight of Bioactive Compounds

Food Frontiers, Volume 7, Issue 1, January 2026.
The presented review provides the potential antihypertensive benefits of traditionally employed edible seeds, presenting new perspectives and avenues for future research. ABSTRACT Hypertension, often referred to as a silent killer, is responsible for 7.5 million deaths, representing approximately 12.8% of all global mortality.
Jinmin Shi, Mohamad Fawzi Mahomoodally, Ahmed Abduljalal Abduljabbar, Ruttun Bushra Umme Zainab, Katharigatta N. Venugopala, Gokhan Zengin, Sakina Yagi, Meng‐Yao Li, Xuebo Hu   +8 more
wiley   +1 more source

Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling. [PDF]

, 2014
Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic ...
Barrese, V, Femminella, GD, Ferrara, N, Rengo, G   +3 more
core   +2 more sources

Relationship between antihypertensive medications and cognitive impairment: Part II. Review of Physiology and animal studies [PDF]

, 2016
Purpose of Review There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHM) and dementia risk are
Carlson, MC, Peters, J, Peters, R, Schuchman, M, Yasar, S   +4 more
core   +1 more source