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Reactions Weekly, 2021 Some of the next articles are maybe not open access.
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Reactions Weekly, 2013
Carvedilol ((2RS)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol), a β1-, β2-, and α1-adrenoreceptor blocker drug with antioxidant and antiproliferative effects, is indicated for treatment of hypertension, stable angina pectoris, and congestive heart failure.
Kevin, Beattie +2 more
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Carvedilol ((2RS)-1-(9H-carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol), a β1-, β2-, and α1-adrenoreceptor blocker drug with antioxidant and antiproliferative effects, is indicated for treatment of hypertension, stable angina pectoris, and congestive heart failure.
Kevin, Beattie +2 more
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The pharmacology of carvedilol
European Journal of Clinical Pharmacology, 1990Carvedilol is a potent antihypertensive agent with a dual mechanism of action. At relatively low concentrations it is a competitive beta-adrenoceptor antagonist and a vasodilator, whereas at higher concentrations it is also a calcium channel antagonist.
R R, Ruffolo +4 more
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The American Journal of Cardiology, 2004
Carvedilol is a third-generation, neurohormonal antagonist with multiple activities. It blocks both beta(1)- and beta(2)-adrenergic receptors, enhances vasodilation via alpha(1)-adrenergic blockade, and, at high concentrations, has ion channel-blocking activities. Carvedilol lacks sympathomimetic activity.
Brian, Dulin, William T, Abraham
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Carvedilol is a third-generation, neurohormonal antagonist with multiple activities. It blocks both beta(1)- and beta(2)-adrenergic receptors, enhances vasodilation via alpha(1)-adrenergic blockade, and, at high concentrations, has ion channel-blocking activities. Carvedilol lacks sympathomimetic activity.
Brian, Dulin, William T, Abraham
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Carvedilol for Systemic Hypertension
Journal of Cardiovascular Pharmacology, 1987Twenty-four-hour profiles of intraarterial ambulatory blood pressure (BP) and heart rate were significantly reduced by administration of carvedilol, a new beta-blocking drug with vasodilating properties. Twelve patients were given carvedilol, 25 mg twice daily for 2 weeks; the dose was then increased to 50 mg twice daily if the target BP was not ...
M E, Heber +4 more
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Electrophysiologic Effects of Carvedilol: Is Carvedilol an Antiarrhythmic Agent?
Pacing and Clinical Electrophysiology, 2005The cardiovascular drug carvedilol is characterized by multiple pharmacological actions, which translate into a wide‐spectrum therapeutic potential. Its major molecular targets are membrane adrenoceptors, ion channels, and reactive oxygen species. Carvedilol's favorable hemodynamic effects are due to the fact that the drug competitively blocks β1‐, β2‐
Nabil, El-Sherif, Gioia, Turitto
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The Clinical Investigator, 1992
Antihypertensive drugs have differing effects on renal hemodynamics, tubular function, plasma electrolytes, and hormonal responses. Nonselective beta-blockers without intrinsic sympathomimetic activities, such as propranolol, have been reported to reduce renal blood flow and to cause a modest decrease in glomerular filtration rate.
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Antihypertensive drugs have differing effects on renal hemodynamics, tubular function, plasma electrolytes, and hormonal responses. Nonselective beta-blockers without intrinsic sympathomimetic activities, such as propranolol, have been reported to reduce renal blood flow and to cause a modest decrease in glomerular filtration rate.
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Cardiology, 2008
Ambulatory intra-arterial blood pressure recording provides a precise and objective method for the study of antihypertensive drugs and their effects on blood pressure. Application of this technique has shown that β-adrenoreceptor-blocking drugs are only effective during the day when the subject is active.
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Ambulatory intra-arterial blood pressure recording provides a precise and objective method for the study of antihypertensive drugs and their effects on blood pressure. Application of this technique has shown that β-adrenoreceptor-blocking drugs are only effective during the day when the subject is active.
openaire +2 more sources