Results 51 to 60 of about 790 (114)

A Multi‐Stage Drop‐the‐Loser Design With Superiority Boundaries

Statistics in Medicine, Volume 45, Issue 15-17, July 2026.
ABSTRACT Multi‐arm multi‐stage (MAMS) trials have gained popularity, due to their improved efficiency in evaluating multiple treatments. A traditional MAMS trial often decreases the expected sample size of the trial compared with just running a multi‐arm approach, but with the drawback of an increase in maximum sample size.
Peter Greenstreet, Manel Khan, Salmaan Kanji, Pouya Motazedian, Andrew Seely, Stephanie Sibley, Tim Ramsay   +6 more
wiley   +1 more source

Sarcopenia Is Associated With Mortality and Progression of Cirrhosis in Decompensated but Not Compensated Disease—A Multicentre Study

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 1, Page 36-49, July 2026.
In a retrospective cohort of 1,624 adults with cirrhosis, sarcopenia was independently associated with unplanned hospitalization, death, and cirrhosis progression (or death) in patients with decompensated disease. In compensated cirrhosis, sarcopenia was associated only with a higher risk of unplanned hospitalization.
Puneeta Tandon, Sarah Wang, Moon Young Kim, Bart Van Hoek, Daphne Bot, Jeroen L. A. van Vugt, Berend Beumer, Jan Ijzermans, Sunil Taneja, Ajay Duseja, Surender Singh, Maryam Ebadi, Aldo J. Montano‐Loza   +12 more
wiley   +1 more source

ESTIMATION OF CLINICAL AND PHARMACOKINETIC EQUIVALENCE OF ORIGINAL AND GENERIC CARVEDILOLS IN PATIENTS WITH HYPERTENSION OF 1-2 GRADES

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study clinical equivalence of original (DilatrendR, ≪Hoffmann-La Roche≫, Switzerland) and of generic (VedicardolR, ≪Synthesis≫, Russia) carvedilols with estimation of their serum level.
E. I. Bambysheva, S. N. Tolpygina, D. F. Guranda, I. E. Koltunov, V. G. Belolipetskaja, S. J. Martsevich   +5 more
doaj   +1 more source

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, Volume 183, Issue 13, Page 3780-3795, July 2026.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

The Blue Delirium: Serotonin and Anticholinergic Toxicity in a 95‐Year‐Old Woman

Journal of the American Geriatrics Society, EarlyView.
Camila S. Badell, Kathleen Brodowski, Eloy F. Ruiz, Eric Tien Yen Chyn   +3 more
wiley   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Carvedilol for prevention of atrial fibrillation after cardiac surgery: a meta-analysis.

PLoS ONE, 2014
BackgroundPostoperative atrial fibrillation (POAF) remains the most common complication after cardiac surgery. Current guidelines recommend β-blockers to prevent POAF. Carvedilol is a non-selective β-adrenergic blocker with anti-inflammatory, antioxidant,
Hui-Shan Wang, Zeng-Wei Wang, Zong-Tao Yin   +2 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 35, 24 June 2026.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Hemodynamic effect of Carvedilol vs. propranolol in cirrhotic patients: Systematic review and meta-analysis

Annals of Hepatology, 2014
Background. Carvedilol appears to be more effective than propranolol in the treatment of portal hypertension in cirrhotic patients.Aim. To compare the effects of carvedilol vs.
Nancy Aguilar-Olivos, Miguel Motola-Kuba, Roberto Candia, Marco Arrese, Nahúm Méndez-Sánchez, Misael Uribe, Norberto C Chávez-Tapia, M.D.,Ph.D.   +6 more
doaj   +1 more source

Post-carvedilol myocardial function in cats with obstructive hypertrophic cardiomyopathy

Frontiers in Veterinary Science
IntroductionHypertrophic cardiomyopathy (HCM) is the most prevalent cardiac disease in cats, and one phenotype includes obstructive HCM with dynamic left ventricular outflow tract obstruction (DLVOTO). Myocardial function has been reported to be lower in
Takahiro Saito, Takahiro Saito, Ryohei Suzuki, Yunosuke Yuchi, Yunosuke Yuchi, Haru Fukuoka, Shuji Satomi, Shuji Satomi, Takahiro Teshima, Hirotaka Matsumoto   +9 more
doaj   +1 more source