Results 51 to 60 of about 14,835 (171)

Visible Epiglottis in an Older Adult: A Potential Indicator of Presbyphagia

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Macroscopic visualization of the epiglottis during routine oral examination is uncommon but may suggest swallowing dysfunction in older adults. This finding may be associated with age‐related changes in tongue‐base support and may warrant further assessment of swallowing function.
Miki Yamada, Yosuke Iijima, Kenta Ushikubo, Shuto Mochizuki, Shunsuke Hino, Norio Horie, Takahiro Kaneko   +6 more
wiley   +1 more source

Carvedilol prevents impairment of the counterregulatory response in recurrently hypoglycaemic diabetic rats

Endocrinology, Diabetes & Metabolism, 2021
Aim It has been suggested that repeated activation of the adrenergic system during antecedent episodes of hypoglycaemia contributes to the development of counterregulatory failure.
Rawad Farhat, Eliane deSantana‐Van Vliet, Gong Su, Levi Neely, Thea Benally, Owen Chan   +5 more
doaj   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 510-519, August 2026.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Midterm Efficacy of SubcutAneous Implantable CardioVErter‐Defibrillator in ≤ 18 Year‐Old CHILDREN (SAVE CHILDREN‐II Registry)

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
S‐ICD therapy demonstrated favorable mid‐term safety and efficacy in pediatric patients, with durable sensing performance and a low incidence of device‐related infection. ABSTRACT Background The subcutaneous implantable cardioverter‐defibrillator (S‐ICD) avoids transvenous leads and is a promising option for sudden cardiac death (SCD) prevention in ...
Hitoshi Mori, Taisuke Nabeshima, Kota Nagaoka, Hideo Fukunaga, Hidemori Hayashi, Osamu Inaba, Yuhei Isonaga, So Asano, Junichi Nitta, Shigeo Watanabe, Sou Otsuki, Hiroshi Suzuki, Hidehira Fukaya, Jun Kishihara, Toshiyuki Chisaka, Takashi Higaki, Ayako Okada, Hideki Kobayashi, Takayuki Sekihara, Takafumi Oka, Seiichi Sato, Keisuke Yoshino, Hidekazu Kondo, Naohiko Takahashi, Ken Kato, Masaru Miura, Jun Maeda, Shuntaro Tamura, Kentaro Ikeda, Hiroko Goto, Takashi Murakami, Tsutomu Wada, Motoki Takamuro, Tsugutoshi Suzuki, Yuji Ishida, Shingo Sasaki, Takuro Nishimura, Masateru Takigawa, Tomomi Matsuura, Tomohiko Imamura, Satoshi Shizuta, Masato Fukunaga, Maiko Kuroda, Rintaro Hojo, Seiji Fukamizu, Hirohiko Suzuki, Yukihiko Yoshida, Itsuro Morishima, Kenji Kuraishi, Eiki Nishihara, Yoshihisa Naruse, Tomoyuki Sato, Yoshiyasu Aizawa, Kimitaka Nishizaki, Kentaro Nakamura, Norihito Nuruki, Masao Yoshinaga, Yukitoshi Ikeya, Yasuo Okumura, Shota Muraji, Yusuke Kondo, Makoto Nakano, Machiko Kito, Yasuya Inden, Satoshi Higuchi, Takahiko Kinjo, Kazuhisa Matsumoto, Masataka Narita, Wataru Sasaki, Tsukasa Naganuma, Daisuke Kawano, Naomichi Tanaka, Kei Matsumoto, Takuro Kojima, Yoshifumi Ikeda, Ritsushi Kato, Naokata Sumitomo   +76 more
wiley   +1 more source

Successful Defibrillation After Conversion From Fixed‐Tilt to Tuned‐Duration Waveform

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Fixed‐tilt biphasic shocks may become ineffective in high‐impedance states because phase‐2 over‐prolongation disrupts optimal charge neutralization. Waveform tuning based on membrane time constants, as implemented by DeFT Response, shortens phase durations to physiologic ranges and lowers the defibrillation threshold.
Yousaku Okubo, Hisayasu Matsuzaki, Shogo Miyamoto, Hiroshi Oe, Yukiko Nakano   +4 more
wiley   +1 more source

ESTIMATION OF CLINICAL AND PHARMACOKINETIC EQUIVALENCE OF ORIGINAL AND GENERIC CARVEDILOLS IN PATIENTS WITH HYPERTENSION OF 1-2 GRADES

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study clinical equivalence of original (DilatrendR, ≪Hoffmann-La Roche≫, Switzerland) and of generic (VedicardolR, ≪Synthesis≫, Russia) carvedilols with estimation of their serum level.
E. I. Bambysheva, S. N. Tolpygina, D. F. Guranda, I. E. Koltunov, V. G. Belolipetskaja, S. J. Martsevich   +5 more
doaj   +1 more source

Coronary Microvascular Dysfunction: Epidemiology, Pathophysiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 8, August 2026.
This visual summary illustrates the key aspects of coronary microvascular dysfunction (CMD) in angina with nonobstructive coronary artery disease (NOCAD), including epidemiology, pathophysiology (microvascular remodeling and endothelial dysfunction), the protective NRG‐1/ErbB signaling pathway, diagnostic methods, and both Western and traditional ...
Zhao Ge, MaoZe Zhang, Xujin Ning, Yijia Du, Lishuo Su, Xudong Wu, Jingyi Zhang, Tongzuo Liu, Xianliang Wang   +8 more
wiley   +1 more source

Carvedilol for prevention of atrial fibrillation after cardiac surgery: a meta-analysis.

PLoS ONE, 2014
BackgroundPostoperative atrial fibrillation (POAF) remains the most common complication after cardiac surgery. Current guidelines recommend β-blockers to prevent POAF. Carvedilol is a non-selective β-adrenergic blocker with anti-inflammatory, antioxidant,
Hui-Shan Wang, Zeng-Wei Wang, Zong-Tao Yin   +2 more
doaj   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, Volume 183, Issue 15, Page 4321-4343, August 2026.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Hemodynamic effect of Carvedilol vs. propranolol in cirrhotic patients: Systematic review and meta-analysis

Annals of Hepatology, 2014
Background. Carvedilol appears to be more effective than propranolol in the treatment of portal hypertension in cirrhotic patients.Aim. To compare the effects of carvedilol vs.
Nancy Aguilar-Olivos, Miguel Motola-Kuba, Roberto Candia, Marco Arrese, Nahúm Méndez-Sánchez, Misael Uribe, Norberto C Chávez-Tapia, M.D.,Ph.D.   +6 more
doaj   +1 more source