Results 41 to 50 of about 905,853 (309)

Rapid simulation of water levels in the Dongting Lake region based on Transformer model

Shui kexue jinzhan
To achieve a rapid and accurate simulation of water level variations in the Dongting Lake region，two deep learning models，i.e.，the TRANS-LSTM and TRANS-LSTM-SE models which incorporate the Transformer architecture and the squeeze-and-excitation (SE ...
Chenglong LI, Shenglian GUO, Xin XIANG, Peng LI, Weimin SHU, Zhiming LIANG   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Do children receiving care and support have higher rates of school exclusion than their peers?

International Journal of Population Data Science
The Children, Young People and Education Committee recently held an inquiry to scrutinise the Welsh Government’s progress in delivering its Programme for Government Commitment to ‘explore radical reform of current services for children looked after and ...
Helen Hodges
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

High-Frequency Modulation Spectroscopy with a THz Quantum-Cascade Laser [PDF]

, 2013
A terahertz absorption spectrometer with a quantum-cascade laser (QCL) for high-resolution molecular spectroscopy is realized. The spectrometer is based on highfrequency (up to 50 MHz) modulation of the QCL frequency.
H.-W. Hubers, H. Richter, Richter, Heiko, Schrottke, Lutz, Grahn, H. T., Eichholz, Rene, Hübers, Heinz-Wilhelm, Wienold, Martin, R. Eichholz, M. Wienold, L. Schrottke, H. T. Grahn   +11 more
core   +1 more source

Bridging Local Concerns and Systemic Change: A Design-Based Approach to Transformative Climate Education

Canadian Journal of Education
This article presents the initial research and development phases of a transformative climate education program for adults in a semi-rural community on southern Vancouver Island. Using design-based research (DBR), we developed a workshop series informed
Shandell Houlden, Elizabeth Lange
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

3D unsteady flow in oscillating compressor cascade [PDF]

, 2004
An experimental and computational study has been carried out to enhance current understanding of three dimensional (3D) cascade aeroelastic mechanisms. 3D unsteady pressure data produced during executing this project is the first-of-its-kind, which can ...
Yang, Hui
core  

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source