Results 61 to 70 of about 1,471,094 (304)

EGMF Constraints from Simultaneous GeV-TeV Observations of Blazars [PDF]

, 2011
Attenuation of the TeV gamma-ray flux from distant blazars through pair production with extragalactic background light leads to the development of electromagnetic cascades and subsequent, lower energy, GeV secondary gamma-ray emission.
A. M. Taylor, A. Neronov, Abdo, Acciari, Acciari, Acciari, Aharonian, Aharonian, Aharonian, Aharonian, Aharonian, Banerjee, Barrow, Beck, Blasi, Coppi, Dolag, Dolag, Durrer, d’Avezac, Elyiv, Eungwanichayapant, Franceschini, Gnedin, Grasso, I. Vovk, Kronberg, Kronberg, Kronberg, Kronberg, Kulsrud, Miniati, Murase, Neronov, Neronov, Neronov, Perkins, Plaga, Pudritz, Taylor, Vallee, Widrow, Zdziarski   +42 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Gaps in the Child Tuberculosis Care Cascade in 32 Rural Communities in Uganda and Kenya. [PDF]

, 2017
Background:Reducing tuberculosis (TB) deaths among children requires a better understanding of the gaps in the care cascade from TB diagnosis to treatment completion.
Ayieko, James, Bukusi, Elizabeth A, Chamie, Gabriel, Charlebois, Edwin D, Clark, Tamara D, Cohen, Craig R, Havlir, Diane V, Kamya, Moses R, Kwarisiima, Dalsone, Marquez, Carina, Mwangwa, Florence, Owaraganise, Asiphas, Petersen, Maya, Plenty, Albert, Ruel, Theodore D, Tram, Khai Hoan   +15 more
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Do children receiving care and support have higher rates of school exclusion than their peers?

International Journal of Population Data Science
The Children, Young People and Education Committee recently held an inquiry to scrutinise the Welsh Government’s progress in delivering its Programme for Government Commitment to ‘explore radical reform of current services for children looked after and ...
Helen Hodges
doaj   +1 more source

Energy transport in weakly nonlinear wave systems with narrow frequency band excitation

, 2012
A novel discrete model (D-model) is presented describing nonlinear wave interactions in systems with small and moderate nonlinearity under narrow frequency band excitation.
Kartashova, Elena
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Improved triplet loss for domain adaptation

IET Computer Vision
A technique known as domain adaptation is utilised to address classification challenges in an unlabelled target domain by leveraging labelled source domains.
Xiaoshun Wang, Yunhan Li, Xiangliang Zhang   +2 more
doaj   +1 more source

Predictive Testing for Tumor Predisposition Syndromes in Pediatric Relatives: An Asian Experience

Frontiers in Pediatrics, 2020
Approximately 10% of pediatric cancer patients possess germline pathogenic/likely pathogenic variants (PV/LPV) in known tumor predisposition genes.
Jianbang Chiang, Jeanette Yuen, Tarryn Shaw, Hui Xuan Goh, Shao-Tzu Li, Eliza Courtney, Joanne Ngeow, Joanne Ngeow   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source