Results 81 to 90 of about 1,471,094 (304)

Cascading on extragalactic background light

, 2007
High-energy gamma-rays propagating in the intergalactic medium can interact with background infrared photons to produce e+e- pairs, resulting in the absorption of the intrinsic gamma-ray spectrum.
Aharonian, Aharonian, Aharonian, Aharonian, B. Giebels, Biller, Cheng, Dai, G. Dubus, Jones, Kronberg, Lagache, P. d'Avezac, Patiri, Peiris, Plaga, Primack, Protheroe, Protheroe, Stecker, Vallée, Widrow, Xu, Zdziarski   +23 more
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Heteroatom self-doped graphitic carbon materials from Sargassum thunbergii with improved supercapacitance performance

Advanced Sensor and Energy Materials
It is well-known that high specific surface area and improved pore structure is significantly desired for the application of supercapacitor based on biomass-based activated carbon. Herein, Sargassum thunbergii was selected as carbon precursor.
Hui Xu, Lina Dong, Bing Zhang, Kun Wang, Jiafeng Meng, Yanwei Tong, Hua Wang   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Polycrisis in the Anthropocene: an invitation to contributions and debates

Global Sustainability
The popularity of the term polycrisis suggests a growing demand for new thinking about the world's intersecting crises, but loose and haphazard uses of the concept impede knowledge generation.
Michael Lawrence
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Pairwise Similarity for Domain Adaptation

IEEE Access
The application of the domain adaptation technique enables the resolution of classification challenges in an unlabeled target domain by leveraging the labeled information from source domains.
Xiaoshun Wang, Sibei Luo
doaj   +1 more source

Reservoirs optimization with dynamic programming

Vietnam Journal of Mechanics, 2017
Differential Evolution (DE) and Dynamic Programming (DP) are important optimal methods in reservoir regulation. In the previous work [1], we presented the outline of DE, and applied it into Pleikrong reservoir, a big one in the Highland of Vietnam for ...
Phan Thi Thu Phuong, Dao Thi Ngoc Han, Hoang Van Lai, Bui Minh Tri   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source