Results 51 to 60 of about 905,853 (309)
Predictive Testing for Tumor Predisposition Syndromes in Pediatric Relatives: An Asian Experience
Frontiers in Pediatrics, 2020 Approximately 10% of pediatric cancer patients possess germline pathogenic/likely pathogenic variants (PV/LPV) in known tumor predisposition genes.
Jianbang Chiang +7 more
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Progress towards photonic crystal quantum cascade laser [PDF]
, 2004 The work describes recent progress in the design, simulation, implementation and characterisation of photonic crystal (PhC) GaAs-based quantum cascade lasers (QCLs).
Stanley, C.R. +3 more
core +1 more source
Real-Time Observation of Target Search by the CRISPR Surveillance Complex Cascade
Cell Reports, 2017 CRISPR-Cas systems defend bacteria and archaea against infection by bacteriophage and other threats. The central component of these systems are surveillance complexes that use guide RNAs to bind specific regions of foreign nucleic acids, marking them for
Chaoyou Xue +4 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
A Theoretical Comparative Study of CO2 Cascade Refrigeration Systems
Applied Sciences, 2019 The objective of this work is the comparison of the different cascade refrigeration systems with CO2 in the low-temperature circuit. A total of 18 different cascade refrigeration systems are examined including the CO2/CO2 cascade system.
Evangelos Bellos, Christos Tzivanidis
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Prevalence of polypharmacy: Comparing the status of Indian states
Indian Journal of Community and Family Medicine, 2019 Introduction: The word “poly” is Greek and means many or much. However, the term polypharmacy has been given definitions connected both to the use of more than a certain number of drugs concomitantly and to the clinical appropriateness of drug use ...
Priya Sharma, N L Gupta, H S Chauhan
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Characteristics of R134a/R410A Cascade Heat Pump and Optimization [PDF]
, 2012 Single stage air source heat pump has been widely used around the world. However, it has some drawback, for example, deteriorated heating capacity and COP in cold ambient temperature.
Kim, Min Soo +2 more
core +1 more source