Results 51 to 60 of about 10,100,361 (308)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Novel design method for cascade control structure of electric drives: Closed‐form expressions for control gains via pole placement

IET Control Theory & Applications
Cascade control structures with inner current and outer speed loop, usually utilizing PI controllers, are widely used for electrical drives to meet high‐quality requirements. The present paper introduces design guidelines via pole placement for achieving
Csaba Budai, Tamás Tóth‐Katona, Péter Stumpf   +2 more
doaj   +1 more source

Cooperative Control for Multi-Module Charging Systems of Ultracapacitors

Energies, 2020
Ultracapacitors have recently received great attention for energy storage due to their small pollution, high power density, and long lifetime. In many applications, ultracapacitors need to be charged with a high current, where a multi-module charging ...
Xiaoyong Zhang, Jiaxuan Lei, Heng Li, Hongtao Liao, Jun Peng   +4 more
doaj   +1 more source

The Neural Cascade of Attentional Control

PLOS Biology, 2007
In our complex and multifaceted world, our senses are continuously bombarded with much more information than our brains can fully process. Attention is a critical cognitive function that allows us to select for detailed analysis only the most relevant information at any given moment. The crucial nature of attention is clearly evident in the game “Where'
openaire   +4 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Stability analysis and nonlinear current-limiting control design for DC micro-grids with CPLs

IET Smart Grid, 2020
In this study, a DC micro-grid consisting of multiple paralleled energy resources interfaced by both bidirectional AC/DC and DC/DC boost converters and loaded by a constant power load (CPL) is investigated. By considering the generic dq transformation of
Andrei-Constantin Braitor, George C. Konstantopoulos, George C. Konstantopoulos, Visakan Kadirkamanathan   +3 more
doaj   +1 more source

Dynamic modeling of Terahertz Quantum cascade lasers [PDF]

, 2011
In this paper, the influence of the simplifications made in the four-equation-based set of rate equations describing the dynamic behavior of a Quantum Cascade Laser (QCL) is studied.
Petitjean, Yoann, Destic, Fabien, Mollier, Jean-Claude, Sirtori, Carlo   +3 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Controlling the cascade of corona

Open Science Journal, 2020
The pandemic of the 2019 novel Coronavirus has seen unprecedented exponential growth. Within three months, 192 countries have been affected, crossing more than 1 million confirmed cases and over 60 thousand deaths until the first week of April. Decision making in such a pandemic becomes difficult due to limited data on the nature of the disease and its
openaire   +2 more sources