Results 31 to 40 of about 2,706,420 (286)

A dual-metal catalyzed sequential cascade reaction in an engineered protein cage [PDF]

, 2022
In this study, we describe the creation of an artificial protein cage housing a dual metal-tagged guest protein that catalyzes a linear, two-step sequential cascade reaction.
Judith, Braunreuther, Anna, Fischer, Claudia, Jessen-Trefzer, Regine, Suess, Paul, Ebensperger, Benedikt, Deuringer, Mariia, Zmyslia, Philipp, Lohner, Anita, Becherer   +8 more
core   +1 more source

Nano oxygen chamber by cascade reaction for hypoxia mitigation and reactive oxygen species scavenging in wound healing

Bioactive Materials
Hypoxia, excessive reactive oxygen species (ROS), and impaired angiogenesis are prominent obstacles to wound healing following trauma and surgical procedures, often leading to the development of keloids and hypertrophic scars. To address these challenges,
Xiaoxue Han, Leah Ju, Chai Saengow, Wen Ren, Randy Ewoldt, Timothy Fan, Joseph Irudayaraj   +6 more
doaj   +1 more source

A cascade enzymatic reaction activatable gemcitabine prodrug with an AIE-based intracellular light-up apoptotic probe for in situ self-therapeutic monitoring

, 2017
A cascade enzymatic reaction activatable gemcitabine prodrug was designed as a theranostic platform for in situ self-therapeutic monitoring of pancreatic cancer cells.
Jian Ji, Jue Zhao, Zhihui Qin, Haijie Han, Qiao Jin, Wenzhuo Teng, Tingting Chen   +6 more
core   +1 more source

Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade

, 2022
S.1084-1092An immobilized enzymatic reaction cascade was designed and optimized for the deacidification of grass silage press juice (SPJ), thus facilitating the production of bio-based chemicals.
Schieder, D., Sieber, V., Schenk, G., Guddat, L.W., Carsten, J., Hohagen, H., Schwarz, D.   +6 more
core   +2 more sources

NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis

Redox Biology, 2023
Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism and adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance.
Didem Ilter, Stanislav Drapela, Tanya Schild, Nathan P. Ward, Emma Adhikari, Vivien Low, John Asara, Thordur Oskarsson, Eric K. Lau, Gina M. DeNicola, Melanie R. McReynolds, Ana P. Gomes   +11 more
doaj   +1 more source

ENZYMATIC, CHEMOENZYMATIC AND PHOTOENZYMATIC CASCADE REACTIONS: PERSPECTIVES FOR A MORE SUSTAINABLE ORGANIC SYNTHESIS

, 2022
Chemicals are rarely the result of a single transformation but rather the consequence of several individual reaction steps. Classically, these individual steps are carried out in sequence, including isolation and purification of the intermediate products.
Cintia D. F. Milagre (3966488), Shirley A. Castilho (12653124), Humberto M. S. Milagre (12653127)   +2 more
core   +1 more source

Electro‐Driven Multi‐Enzymatic Cascade Conversion of CO2 to Ethylene Glycol in Nano‐Reactor

Advanced Science
Multi‐enzymatic cascade reaction provides a new avenue for C─C coupling directly from CO2 under mild conditions. In this study, a new pathway with four enzymes including formate dehydrogenase (PaFDH), formaldehyde dehydrogenase (BmFADH), glycolaldehyde ...
Likun Luan, Yingfang Zhang, Xiuling Ji, Boxia Guo, Shaoyu Song, Yuhong Huang, Suojiang Zhang   +6 more
doaj   +1 more source

Enzymatic Cascade Reactions inside Polymeric Nanocontainers: A Means to Combat Oxidative Stress [PDF]

Chemistry – A European Journal, 2011
AbstractOxidative stress, which is primarily due to an imbalance in reactive oxygen species, such as superoxide radicals, peroxynitrite, or hydrogen peroxide, represents a significant initiator in pathological conditions that range from arthritis to cancer.
Tanner, P., Onaca, O., Balasubramanian, V., Meier, W., Palivan, C. G.   +4 more
openaire   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine [PDF]

Journal of Visualized Experiments, 2018
Amino alcohols are versatile compounds with a wide range of applications. For instance, they have been used as chiral scaffolds in organic synthesis. Their synthesis by conventional organic chemistry often requires tedious multi-step synthesis processes, with difficult control of the stereochemical outcome.
Fossey-Jouenne, Aurélie, Vergne-Vaxelaire, Carine, Zaparucha, Anne   +2 more
openaire   +2 more sources