Results 71 to 80 of about 240,463 (263)

Challenges and opportunities in the continuity of care for hypertension: a mixed-methods study embedded in a primary health care intervention in Tajikistan

BMC Health Services Research, 2019
Background Hypertension, a significant risk factor for ischemic heart disease and other chronic conditions, is the third-highest cause of death and disability in Tajikistan. Thus, ensuring the early detection and appropriate management of hypertension is
Adanna Chukwuma, Estelle Gong, Mutriba Latypova, Nicole Fraser-Hurt   +3 more
doaj   +1 more source

The latent tuberculosis infection cascade of care in Iqaluit, Nunavut, 2012–2016

BMC Infectious Diseases, 2019
Background A remote arctic region of Canada predominantly populated by Inuit with the country’s highest incidence of tuberculosis. Methods The study was undertaken to describe the latent tuberculosis infection (LTBI) cascade of care and identify factors ...
Christopher Pease, Alice Zwerling, Ranjeeta Mallick, Mike Patterson, Patricia Demaio, Sandy Finn, Jean Allen, Deborah Van Dyk, Gonzalo G. Alvarez   +8 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Missed Opportunities: A Retrospective Study of Hepatitis C Testing in Hospital Inpatients

Viruses
Increasing testing is key to achieving hepatitis C elimination. This retrospective study aimed to assess the testing cascade of patients at a regional hospital in Victoria, Australia, who inject drugs or are living with hepatitis C, to identify missed ...
Christine Roder, Carl Cosgrave, Kathryn Mackie, Bridgette McNamara, Joseph S. Doyle, Amanda J. Wade   +5 more
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care.

PLoS Medicine, 2019
The cascade of care is a model for evaluating patient retention across sequential stages of care required to achieve a successful treatment outcome. This approach was first used to evaluate HIV care and has since been applied to other diseases.
Ramnath Subbaraman, Ruvandhi R Nathavitharana, Kenneth H Mayer, Srinath Satyanarayana, Vineet K Chadha, Nimalan Arinaminpathy, Nimalan Arinaminpathy, Madhukar Pai   +7 more
doaj   +1 more source

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Differentiated care for youth in Zimbabwe: Outcomes across the HIV care cascade

PLOS Global Public Health
Youth living with HIV are at higher risk than adults of disengaging from HIV care. Differentiated models of care such as community delivery of antiretroviral therapy (ART) may improve treatment outcomes. We investigated outcomes across the HIV cascade among youth accessing HIV services in a community-based setting.
Chido Dziva Chikwari, Katharina Kranzer, Victoria Simms, Amani Patel, Mandikudza Tembo, Owen Mugurungi, Edwin Sibanda, Onismo Mufare, Lilian Ndlovu, Joice Muzangwa, Rumbidzayi Vundla, Abigail Chibaya, Richard Hayes, Constance Mackworth-Young, Sarah Bernays, Constancia Mavodza, Fadzanayi Hove, Tsitsi Bandason, Ethel Dauya, Rashida A Ferrand   +19 more
openaire   +3 more sources

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source

Hospital-based micro-elimination of hepatitis C virus: improving timely case identification and linkage to care in a tertiary hospital

Frontiers in Medicine
BackgroundDespite the availability of highly effective direct-acting antivirals (DAAs), gaps in the hepatitis C virus (HCV) care cascade remain major barriers to elimination.
Xiuli Wang, Lijun Chang, Fankun Kong, Yali Ma, Ying Qin   +4 more
doaj   +1 more source