Results 81 to 90 of about 240,463 (263)

Pretreatment loss to follow-up of tuberculosis patients in Chennai, India: a cohort study with implications for health systems strengthening

BMC Infectious Diseases, 2018
Background Pretreatment loss to follow-up (PTLFU) is a barrier to tuberculosis (TB) control in India’s Revised National TB Control Programme (RNTCP).
Beena E. Thomas, Ramnath Subbaraman, Senthil Sellappan, Chandra Suresh, J. Lavanya, Savari Lincy, Agnes Lawrence Raja, B. Javeed, S. Kokila, S. Arumugam, Soumya Swaminathan, Kenneth H. Mayer   +11 more
doaj   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Challenges and Gaps in the Management of Chronic Hepatitis C Infection: Insight from A Tertiary Hospital in Indonesia

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Background: Hepatitis C virus (HCV) infection remains a significant public health burden in Indonesia, affecting approximately 2.5 million people. The introduction of direct-acting antivirals (DAAs) has revolutionized HCV management by offering highly ...
Lily Chandrawati, Cecilia Octaria Permatadewi, Hesti Triwahyu Hutami, Didik Indiarso, Hery Djagat Purnomo   +4 more
doaj   +1 more source

Quality of tuberculosis care in high burden countries: the urgent need to address gaps in the care cascade

International Journal of Infectious Diseases, 2017
Despite the high coverage of directly observed treatment short-course (DOTS), tuberculosis (TB) continues to affect 10.4 million people each year, and kills 1.8 million.
Danielle Cazabon, Hannah Alsdurf, Srinath Satyanarayana, Ruvandhi Nathavitharana, Ramnath Subbaraman, Amrita Daftary, Madhukar Pai   +6 more
doaj   +1 more source

Acute Endocrine Alterations After Traumatic Brain Injury and 6‐Month Functional Outcome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Acute multi‐axis endocrine alterations after traumatic brain injury (TBI) remain incompletely characterized. This study aimed to examine their temporal patterns and explore their associations with 6‐month functional outcome and early inflammatory markers.
Biao Xu, Peng Guo, Rui Pan, Zhenghao Wang, Jingchao Zhou, Pengcheng Zhang, Xingzhe Zhang, Qinghua Zhang, Haibin Ma, Zhanfeng Niu   +9 more
wiley   +1 more source

Assessing tuberculosis control priorities in high-burden settings: a modelling approach

The Lancet Global Health, 2019
Summary: Background: In the context of WHO's End TB strategy, there is a need to focus future control efforts on those interventions and innovations that would be most effective in accelerating declines in tuberculosis burden. Using a modelling approach
Juan F Vesga, PhD, Timothy B Hallett, ProfPhD, Michael J A Reid, MD, Kuldeep Singh Sachdeva, MBA, Raghuram Rao, DPH, Sunil Khaparde, PhD, Paresh Dave, MPH, Kiran Rade, MD, Maureen Kamene, MSc, Eunice Omesa, MSc, Enos Masini, MPH, Newton Omale, MSc, Elizabeth Onyango, MSc, Philip Owiti, MSc, Muthoni Karanja, MSc, Richard Kiplimo, MSc, Sofia Alexandru, MPH, Valentina Vilc, MPH, Valeriu Crudu, PhD, Stela Bivol, MPH, Cristina Celan, MPH, Nimalan Arinaminpathy, DPhil   +21 more
doaj   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

High levels of heterogeneity in the HIV cascade of care across different population subgroups in British Columbia, Canada.

PLoS ONE, 2014
BackgroundThe HIV cascade of care (cascade) is a comprehensive tool which identifies attrition along the HIV care continuum. We executed analyses to explicate heterogeneity in the cascade across key strata, as well as identify predictors of attrition ...
Lillian Lourenço, Guillaume Colley, Bohdan Nosyk, Dmitry Shopin, Julio S G Montaner, Viviane D Lima, STOP HIV/AIDS Study Group   +6 more
doaj   +1 more source

The Important but Rarely Studied Cascade of Care [PDF]

JAMA Network Open, 2019
John, Mandrola, Daniel J, Morgan
openaire   +2 more sources

Short‐Term Response to Biologic Therapy in Psoriatic Arthritis Is Not Influenced by Disease Duration at Initiation of Therapy

Arthritis Care &Research, EarlyView.
Objective We aimed to determine whether the short‐term response to biologics in biologic‐naive psoriatic arthritis (PsA) is better in patients initiating biologic treatment early in the disease course. Methods Patients with PsA who started on biologic therapy from the year 2000 to 2025 were included for analysis.
Sung Min Cho, Shangyi Gao, Daniel Pereira, Richard J. Cook, Dafna D. Gladman   +4 more
wiley   +1 more source