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Case-control studies are a type of epidemiological study in which subjects are selected based on whether they have the outcome of interest, and then are examined for the presence of a prior exposure. By conditioning on outcome rather than exposure, case-control studies are very well suited to studies of rare outcomes, but are prone to selection bias in
Arno W. Hoes
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Case-control studies are analytical observational epidemiological studies generally devoted to evaluate factors associated with infrequent diseases. Its hierarchy within the pyramid of evidence lies in an intermediate place between cross sectional and ...
Alonso Soto, Aleksandar Cvetkovic-Vega
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Analysis of matched case-control studies [PDF]
There are two common misconceptions about case-control studies: that matching in itself eliminates (controls) confounding by the matching factors, and that if matching has been performed, then a “matched analysis” is required. However, matching in a case-
N. Pearce
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Case-control studies (CSS) are observational analytic studies done often in instances of rare cases or outcomes. In a case-control study, clearly defined cases and controls arising from the same population is compared for well-measured exposures.
Pankajakshan Vijayanthi Indu +1 more
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Methodology series module 2: Case-control studies
Case-Control study design is a type of observational study. In this design, participants are selected for the study based on their outcome status. Thus, some participants have the outcome of interest (referred to as cases), whereas others do not have the
Maninder Singh Setia
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Introduction to Matching in Case-Control and Cohort Studies
Matching is a technique through which patients with and without an outcome of interest (in case-control studies) or patients with and without an exposure of interest (in cohort studies) are sampled from an underlying cohort to have the same or similar ...
Masao Iwagami, Tomohiro Shinozaki
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Factors associated with the recurrence of dengue fever in villages in Chiang Rai, Thailand: A community-based case-control study [PDF]
Purpose - The purpose of this paper is to determine the factors associated with DF occurrence in recurrence villages in Chiang Rai, Thailand. Design/methodology/approach - A case-control study was conducted between June 2017 and December 2017.
Som Mungmonphoncharoen +2 more
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Bacillus of Calmette and Guérin (BCG) and the risk of leprosy in Ciudad del Este, Paraguay, 2016–2017 [PDF]
OBJECTIVES Paraguay has experienced a 35% reduction in the detected incidence of leprosy during the last ten years, as the vaccination coverage against tuberculosis (Bacillus of Calmette and Guérin [BCG] vaccine) reached ≥95% among infants. The objective
Nancy Carolina Cuevas +1 more
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Do Case-Control Studies Always Estimate Odds Ratios?
Case-control studies are an important part of the epidemiologic literature, yet confusion remains about how to interpret estimates from different case-control study designs. We demonstrate that not all case-control study designs estimate odds ratios.
Katherine Curtis-Tyler +3 more
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In genome-wide association studies (GWAS) for thousands of phenotypes in large biobanks, most binary traits have substantially fewer cases than controls.
W. Zhou +18 more
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