Results 91 to 100 of about 2,124,166 (301)

Preclinical obesity curriculum: audit, implementation, and evaluation

BMC Medical Education
Background This study aimed to (1) evaluate the current status of obesity education at Case Western Reserve University School of Medicine (CWRU) (2), introduce a comprehensive first-year curriculum on obesity, and (3) assess the impact of the curriculum ...
Amber Olson, Rosanna Watowicz, Eileen Seeholzer, Katherine Lyons, W. Scott Butsch, Colleen Croniger   +5 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Kwalitatieve evaluatie van 10 jaar zorgcoördinatie en case management in de Oost-Vlaamse drughulpverlening: een rondvraag bij hulpverleners en cliënten [PDF]

, 2007
Sinds 10 jaar wordt door de Provincie Oost-Vlaanderen – in samenwerking met het provinciaal overlegplatform geestelijke gezondheidszorg (PopovGGZ) en alle betrokken voorzieningen – geïnvesteerd in zorgvernieuwing, coördinatie en afstemming van de zorg in
Cole, Sven, De Maeyer, Jessica, Franssen, Alphonse, Vanderplasschen, Wouter   +3 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Systems Thinking and Design Thinking: The Search for Principles in the World We Are Making

She Ji: The Journal of Design, Economics and Innovation, 2019
While the concept of system has been part of design theory and practice from the beginning of the discipline, there is renewed interest today in the relationship of systems thinking and design.
Richard Buchanan
doaj   +1 more source

Case Management Program For Frail Elders Manual, August 2008 [PDF]

, 2008
The purpose of this manual is to guide operation of the Case Management Program for Frail Elders. After Background, Program Administration, Definitions, Consumer Eligibility, and Program Standards, the order follows the flow of a consumer entering the ...

core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Integration of services for older people: back to funding

International Journal of Integrated Care, 2012
Réjean Hébert
doaj   +3 more sources

The use of Coercive Interventions in Mental Health Care in Germany and the Netherlands. A comparison of the developments in two neighbouring countries

Frontiers in Public Health, 2014
In this review we compare the use of coercion in mental health care in Germany and in the Netherlands. Legal frameworks and published data on involuntary commitment, involuntary medication, seclusion, and restraint are highlighted as well as the role of ...
Tilman eSteinert, Tilman eSteinert, Eric eNoorthoorn, Cornelis L. Mulder   +3 more
doaj   +1 more source