Results 121 to 130 of about 91,991,955 (298)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Anesthesiology Manpower Planning Study Phase III - Final Report

Operations Research ...
Reisman, A. (Creatorcre), Emmons, H. (Creatorcre), Lin, M. (Creatorcre), George, T. (Creatorcre), Darakhanavala, P. (Creatorcre), Dean, B. V. (Creatorcre), deKluyver, C. A. (Creatorcre), Gravenstein, J. S. (Creatorcre), Staub, F. (Creatorcre), Rasmussen, J. (Creatorcre)   +9 more
core  

Case study research in information technology: a prescriptive methodology [PDF]

, 1998
The case study research strategy offers the field of Information Technology a strong qualitative analysis method. Currently available descriptions of the method can however be considered lacking in process structure.
Gable, Guy G., Pocknee, Fraser
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Agricultural Plant Protection: A Study of the Economics of Information

Operations Research ...
Dinur, Amos (Creatorcre), Gelb, Ehud (Creatorcre), Schpar, Amit (Creatorcre), Pollak, David (Creatorcre), Reisman, Arnold (Creatorcre)   +4 more
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Day centres for older people - attender characteristics, access routes and outcomes of regular attendance: findings of exploratory mixed methods case study research. [PDF]

BMC Geriatr, 2020
Orellana K, Manthorpe J, Tinker A.
europepmc   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Identifying stakeholder preferences for communicating impact from medical research: a mixed methods study

BMC Health Services Research
Background Documentation of research outcomes using impact case studies (ICS) is increasingly required to demonstrate the wider societal benefits of research.
Katherine Pitrolino, Buddhini Samarasinghe, Andy Pringle, Ian Viney   +3 more
doaj   +1 more source