Results 171 to 180 of about 4,619 (182)
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Angewandte Chemie International Edition, 2015
AbstractListeria monocytogenes is a devastating bacterial pathogen. Its virulence and intracellular stress tolerance are supported by caseinolytic protease P (ClpP), an enzyme that is conserved among bacteria. L. monocytogenes expresses two ClpP isoforms that are only distantly related by sequence and differ in catalysis, oligomerization, active‐site ...
Maria Dahmen +3 more
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AbstractListeria monocytogenes is a devastating bacterial pathogen. Its virulence and intracellular stress tolerance are supported by caseinolytic protease P (ClpP), an enzyme that is conserved among bacteria. L. monocytogenes expresses two ClpP isoforms that are only distantly related by sequence and differ in catalysis, oligomerization, active‐site ...
Maria Dahmen +3 more
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Discovery of Dehydrogenated Imipridone Derivatives as Activators of Human Caseinolytic Protease P
Journal of Medicinal ChemistryBased on the founding member of imipridones, ONC201, a class of dehydrogenated imipridone derivatives was designed, synthesized, and evaluated in a series of biochemical and biological assays as human caseinolytic protease P (hClpP) activators. Mechanism studies for one of the most potent compounds, XT6, indicated that it can potently bind to both ...
Jinxin Jiang +9 more
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Caseinolytic Protease P: A Therapeutic Nexus in Infection, Inflammation, and Immunity
Critical Reviews in ImmunologyCaseinolytic protease P (ClpP) is a highly conserved serine protease that plays a pivotal role in protein homeostasis and quality control in bacteria, mitochondria of mammalian cells, and plant chloroplasts. As the proteolytic core of the ATP-dependent Clp protease complex, ClpP partners with regulatory ATPases (e.g., ClpX, ClpA) to degrade misfolded ...
Shreya S. Sonak +3 more
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Bioorganic & Medicinal Chemistry Letters, 2015
Caseinolytic protein proteases (ClpP) are large oligomeric protein complexes that contribute to cell homeostasis as well as virulence regulation in bacteria. Inhibitors of ClpP can significantly attenuate the capability to produce virulence factors of the bacteria.
Guanzhong Wu +3 more
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Caseinolytic protein proteases (ClpP) are large oligomeric protein complexes that contribute to cell homeostasis as well as virulence regulation in bacteria. Inhibitors of ClpP can significantly attenuate the capability to produce virulence factors of the bacteria.
Guanzhong Wu +3 more
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Inquiries into the Mycobacterial Caseinolytic Protease System
A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...openaire +1 more source
Process Biochemistry
The caseinolytic protease (ClpP)-producing strain CHFM, isolated from Algerian goat milk, was identified as Lactiplantibacillus pentosus through 16 S rRNA sequence analysis. The optimal conditions for ClpP expression by Lpb. pentosus CHFM were determined in a modified MRS medium, where peptone was replaced with casein.
Zater, Zohra Yasmine +5 more
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The caseinolytic protease (ClpP)-producing strain CHFM, isolated from Algerian goat milk, was identified as Lactiplantibacillus pentosus through 16 S rRNA sequence analysis. The optimal conditions for ClpP expression by Lpb. pentosus CHFM were determined in a modified MRS medium, where peptone was replaced with casein.
Zater, Zohra Yasmine +5 more
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Caseinolytic and milk-clotting activities from Moringa oleifera flowers
Food Chemistry, 2012Emmanuel V Pontual +1 more
exaly