Results 151 to 160 of about 147,909 (161)

The Mechanism of Caseinolytic Protease (ClpP) Inhibition

Angewandte Chemie International Edition, 2013
Gersch, Malte, Gut, Felix, Korotkov, Vadim S., Lehmann, Johannes, Böttcher, Thomas, Rusch, Marion, Hedberg, Christian, Waldmann, Herbert, Klebe, Gerhard, Sieber, Stephan A.   +9 more
openaire   +3 more sources

Impact of a novel caseinolytic protease single mutation on Lactiplantibacillus pentosus growth performance

Process Biochemistry
The caseinolytic protease (ClpP)-producing strain CHFM, isolated from Algerian goat milk, was identified as Lactiplantibacillus pentosus through 16 S rRNA sequence analysis. The optimal conditions for ClpP expression by Lpb. pentosus CHFM were determined in a modified MRS medium, where peptone was replaced with casein.
Zater, Zohra Yasmine, BALTACI, Mustafa Özkan, ADIGÜZEL, Ahmet, Merzoug, Mohamed, Todorov, Svetoslav Dimitrov, Roudj, Salima   +5 more
openaire   +2 more sources

Design, Synthesis, and Biological Evaluation of Novel Activators of Human Caseinolytic Protease P with a Pyrazololactam Scaffold

Journal of Medicinal Chemistry
Based on D9, a previously reported small-molecule agonist of hClpP, a class of novel hClpP activators with a pyrazololactam scaffold was designed and synthesized. Detailed structure-activity relationship studies (SAR) for this class of compounds led to the identification of compound 24, which potently activated recombinant hClpP in a proteolysis assay ...
Rui Tang, Qiannan Li, Heyang Zhou, Yu Li, Tong Li, Jinxin Jiang, Ziyuan Chen, Lingmei Kong, Yan Li, Yibei Xiao, Haiying Sun   +10 more
openaire   +2 more sources

Catalytic Properties of Caseinolytic Protease Subunit of Plasmodium knowlesi and Its Inhibition by a Member of δ-Lactone, Hyptolide

Molecules, 2022
Ruzaidi Azli Mohd Mokhtar, Meiny Suzery, Cahyo Budiman   +2 more
exaly  

Insights Into the Inter-Ring Plasticity of Caseinolytic Proteases From the X-Ray Structure of Mycobacterium tuberculosis ClpP1

Acta Crystallographica Section D: Biological Crystallography, 2007
Martin Högbom, Pedro M. Alzari, Nadia Benaroudj   +2 more
exaly  

The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease

Angewandte Chemie International Edition, 2011
Esther K, Schmitt, Meliana, Riwanto, Vasan, Sambandamurthy, Silvio, Roggo, Charlotte, Miault, Christian, Zwingelstein, Philipp, Krastel, Christian, Noble, David, Beer, Srinivasa P S, Rao, Melvin, Au, Pornwaratt, Niyomrattanakit, Viviam, Lim, Jun, Zheng, Douglas, Jeffery, Kevin, Pethe, Luis R, Camacho   +16 more
openaire   +2 more sources

De Novo Design of Caseinolytic Protein Proteases Inhibitors Based on Pharmacophore and 2D Molecular Fingerprints

Bioorganic and Medicinal Chemistry Letters, 2015
Kejiang Lin, Zhen Zhang
exaly  

Caseinolytic and Milk-Clotting Activities From Moringa oleifera Flowers

Food Chemistry, 2012
Thiago Henrique Napoleão, Luana Cassandra Breitenbach Barroso Coelho, Emmanuel V Pontual   +2 more
exaly  

BORTEZOMIB AS AN INHIBITOR OF MYCOBACTERIAL CASEINOLYTIC PROTEASE (CLP) FOR TREATMENT OF TUBERCULOSIS

2016
DICK THOMAS, MOREIRA WILFRIED, RUBIN ERIC J, RAJU RAVIKIRAN, CHIA CHENG SAN BRIAN   +4 more
openaire   +1 more source

Structural characterization of caseinolytic protease (ClpP) from Klebsiella pneumonia.

openaire   +1 more source