Results 1 to 10 of about 13,300 (205)

Mitochondrial Protease ClpP: Cancer Marker and Drug Target [PDF]

Pharmaceuticals
Background: The human mitochondrial ClpP is a serine protease located in the mitochondrial matrix responsible for degrading short lived regulatory proteins as well as misfolded or damaged proteins, thereby maintaining cellular homeostasis.
Domenico Armenise, Olga Maria Baldelli, Anselma Liturri, Gianfranco Cavallaro, Cosimo Gianluca Fortuna, Savina Ferorelli, Morena Miciaccia, Maria Grazia Perrone, Antonio Scilimati   +8 more
doaj   +5 more sources

Targeting mitochondrial ClpP: structural insights and therapeutic potential of ClpP agonists in cancer therapy

Oncology Reviews
Mitochondrial “powerhouses” play a central function in cellular metabolism and energy generation. Their dysregulation is directly correlated with a myriad of diseases, among them cancer. The serine protease ClpP, accompanied by its cochaperone ClpX, is a
Mowei Kong, Yang Yu, Shuai Shao, Chunxiang Zhang   +3 more
doaj   +4 more sources

Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma

Nature Communications, 2023
Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However, we are currently unaware of any studies using selective and potent ClpP activators in lung squamous cell carcinoma.
Lin-Lin Zhou, Tao Zhang, Yun Xue, Chuan Yue, Yihui Pan, Pengyu Wang, Teng Yang, Meixia Li, Hu Zhou, Kan Ding, Jianhua Gan, Hongbin Ji, Cai-Guang Yang   +12 more
doaj   +2 more sources

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis

Communications Biology, 2023
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria.
Chenxi Guo, Yuan Xiao, Jingkai Gu, Peikun Zhao, Zhe Hu, Jiahuan Zheng, Renwu Hua, Zhuo Hai, Jiaping Su, Jian V. Zhang, William S. B. Yeung, Tianren Wang   +11 more
doaj   +2 more sources

CLPP inhibition triggers apoptosis in human ovarian granulosa cells via COX5A abnormality–Mediated mitochondrial dysfunction

Frontiers in Genetics, 2023
Premature ovarian insufficiency (POI) is characterized by early loss of ovarian function before the age of 40 years. It is confirmed to have a strong and indispensable genetic component.
Xiong Yuan, Xiong Yuan, Wenjie Ma, Wenjie Ma, Shuping Chen, Shuping Chen, Huiyuan Wang, Huiyuan Wang, Chenyi Zhong, Chenyi Zhong, Li Gao, Li Gao, Yugui Cui, Yugui Cui, Danhua Pu, Danhua Pu, Rongrong Tan, Rongrong Tan, Jie Wu, Jie Wu   +19 more
doaj   +2 more sources

Nepetin reduces virulence factors expression by targeting ClpP against MRSA-induced pneumonia infection

Virulence, 2022
The resistance of Staphylococcus aureus (S. aureus) to various antibiotics has increased dramatically due to the misuse of antibiotics, and thus the development of new anti-infective drugs with new targets is urgently needed to combat resistance ...
Shisong Jing, Xinran Ren, Li Wang, Xiangri Kong, Xingye Wang, Xiren Chang, Xuerui Guo, Yan Shi, Jiyu Guan, Tiedong Wang, Bingmei Wang, Wu Song, Yicheng Zhao   +12 more
doaj   +2 more sources

Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma

Cell Chemical Biology, 2022
The mitochondrial caseinolytic protease P (ClpP) is a target candidate for treating leukemia; however, the effects of ClpP modulation on solid tumors have not been adequately explored.
Cai-Guang Yang, Xiongxiong Lu
exaly   +2 more sources

Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease models [PDF]

Molecular Neurodegeneration
Background Mitochondrial dysfunction and α-Synuclein (αSyn) aggregation are defining features of Parkinson’s disease (PD), yet the mechanistic link between them remains poorly understood.
Di Hu, Xiaoyan Sun, Xin Qi
doaj   +2 more sources

Quercetin Reduces the Virulence of S. aureus by Targeting ClpP to Protect Mice from MRSA-Induced Lethal Pneumonia

Microbiology Spectrum, 2022
The dramatic increase of methicillin-resistant Staphylococcus aureus (MRSA) poses a great challenge to the treatment of Staphylococcus aureus (S. aureus) infections. Therefore, there is an urgent need to identify novel anti-infective agents to attack new
Shisong Jing, Xiangri Kong, Li Wang, Heming Wang, Jiaxuan Feng, Lin Wei, Ying Meng, Chang Liu, Xiren Chang, Yishen Qu, Jiyu Guan, Haimiao Yang, Chi Zhang, Yicheng Zhao, Wu Song   +14 more
doaj   +2 more sources

Mode of action guided metagenomic natural product discovery reveals convergent evolution of a ClpP-targeting motif [PDF]

Nature Communications
The discovery of natural products with specific modes of action from metagenomes remains challenging. Here, we present resistance-CONKAT-seq, a pipeline that links biosynthetic gene clusters (BGCs) to self-resistance genes, enabling identification of ...
Jingbo Kan, Kaylyn Spotton, Adrian Morales-Amador, Yozen Hernandez, Ján Burian, Cecilia Panfil, Melinda A. Ternei, Robert E. Boer, Abir Bhattacharjee, Sean F. Brady   +9 more
doaj   +2 more sources