Results 31 to 40 of about 13,300 (205)

Turned on for degradation: ATPase-independent degradation by ClpP [PDF]

Journal of Structural Biology, 2009
Clp is a barrel-shaped hetero-oligomeric ATP-dependent protease comprising a hexameric ATPase (ClpX or ClpA) that unfolds protein substrates and translocates them into the central chamber of the tetradecameric proteolytic component (ClpP) where they are degraded processively to short peptides. Chamber access is controlled by the N-terminal 20 residues (
Maria C, Bewley, Vito, Graziano, Kathleen, Griffin, John M, Flanagan   +3 more
openaire   +2 more sources

Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer

Frontiers in Pharmacology, 2023
ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in vitro and in vivo studies, including clinical trials for refractory solid tumors. Though progress has been made
E. Fennell, Lucas J. Aponte-Collazo, W. Pathmasiri, B. Rushing, Natalie K Barker, M. Partridge, Yuan-Yuan Li, Cody A White, Y. Greer, Laura E. Herring, S. Lipkowitz, S. Sumner, E. Iwanowicz, Lee M. Graves   +13 more
semanticscholar   +1 more source

Soil Microbial Activity and Diversity in Response to Soil Chemical Factors in Agricultural Soils

Journal of Tropical Soils, 2019
The role of microbial communities in maintaining soil health is mostly influenced by chemical condition of soil. Microbial communities vary in response to soil chemical factors.
Lily Ishak, Philip Hugh Brown
doaj   +1 more source

Evaluation the effect of cultivated land protection policies based on the cloud model: A case study of Xingning, China

Ecological Indicators, 2021
The evaluation of the effects of cultivated land protection policies (CLPP) is an important issue in China’s food security and land policy regulation. This article first analyzes the historical evolution of CLPP in China and divides it into five stages ...
Xinhai Lu, Yanwei Zhang, Yucheng Zou
doaj   +1 more source

A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology

Antimicrobial Agents and Chemotherapy, 2023
Daptomycin is a last-resort antibiotic used for the treatment of infections caused by Gram-positive antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA).
Lijuan Xu, C. Henriksen, V. Mebus, R. Guérillot, A. Petersen, Nicolas Jacques, Jhih-hang Jiang, R. Derks, Elena Sánchez-López, M. Giera, Kirsten Leeten, T. Stinear, C. Oury, B. Howden, A. Peleg, D. Frees   +15 more
semanticscholar   +1 more source

Ureadepsipeptides as ClpP Activators

ACS Infectious Diseases, 2019
Acyldepsipeptides are a unique class of antibiotics that act via allosterically dysregulated activation of the bacterial caseinolytic protease (ClpP). The ability of ClpP activators to kill nongrowing bacteria represents a new opportunity to combat deep-seated biofilm infections.
Elizabeth C. Griffith, Ying Zhao, Aman P. Singh, Brian P. Conlon, Rajendra Tangallapally, William R. Shadrick, Jiuyu Liu, Miranda J. Wallace, Lei Yang, John M. Elmore, Yong Li, Zhong Zheng, Darcie J. Miller, Martin N. Cheramie, Robin B. Lee, Michael D. LaFleur, Kim Lewis, Richard E. Lee   +17 more
openaire   +3 more sources

A review of current therapeutics targeting the mitochondrial protease ClpP in diffuse midline glioma, H3 K27-altered

Neuro-Oncology, 2023
Diffuse midline gliomas (DMGs) are devastating pediatric brain tumors recognized as the leading cause of cancer-related death in children. DMGs are high-grade gliomas (HGGs) diagnosed along the brain’s midline. Euchromatin is the hallmark feature of DMG,
Evangeline R. Jackson, Mika L Persson, Cameron J Fish, Izac J. Findlay, S. Mueller, J. Nazarian, E. Hulleman, J. van der Lugt, Ryan J. Duchatel, Matthew D. Dun   +9 more
semanticscholar   +1 more source

Mitochondrial stress response gene Clpp deficiency impairs oocyte competence and deteriorate cyclophosphamide-induced ovarian damage in young mice

Frontiers in Endocrinology, 2023
Chemotherapy is extensively used to treat cancers and is often associated with ovarian damage and leads to premature ovarian insufficiency and infertility, while the role of mitochondria during ovarian damage with chemotherapy remains unknown. This study
Guangxin Li, J. Gu, Xiaomei Zhou, Ting Wu, Xian Li, Renwu Hua, Z. Hai, Yuan Xiao, J. Su, Willian S. B. Yeung, Kui Liu, Chenxi Guo, Tianren Wang   +12 more
semanticscholar   +1 more source

Catalytic Properties of Caseinolytic Protease Subunit of Plasmodium knowlesi and Its Inhibition by a Member of δ-Lactone, Hyptolide

Molecules, 2022
The caseinolytic protease (Clp) system plays an essential role in the protein homeostasis of the malaria parasite, particularly at the stage of apicoplast development. The inhibition of this protein is known to have a lethal effect on the parasite and is
Cahyo Budiman, Raimalynah Abd Razak, Angelesa Runin Anak Unggit, Rafida Razali, Meiny Suzery, Ruzaidi Azli Mohd Mokhtar, Ping-Chin Lee, Didik Huswo Utomo   +7 more
doaj   +1 more source

Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A.

Angewandte Chemie, 2023
The caseinolytic protease is a highly conserved serine protease, crucial to prokaryotic and eukaryotic protein homeostasis, and a promising antibacterial and anticancer drug target.
Astrid Illigmann, Marie-Theres Vielberg, Markus Lakemeyer, Felix Wolf, Taulant Dema, Patrik Stange, Wolfgang Kuttenlochner, Elisa Liebhart, Andreas Kulik, Nicole D. Staudt, Imran T Malik, S. Grond, S. Sieber, Leonard Kaysser, M. Groll, H. Brötz-Oesterhelt   +15 more
semanticscholar   +1 more source