Results 31 to 40 of about 13,032 (201)

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis

Communications Biology, 2023
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria.
Chenxi Guo, Yuan Xiao, Jingkai Gu, Peikun Zhao, Zhe Hu, Jiahuan Zheng, Renwu Hua, Zhuo Hai, Jiaping Su, Jian V. Zhang, William S. B. Yeung, Tianren Wang   +11 more
doaj   +1 more source

Catalytic Properties of Caseinolytic Protease Subunit of Plasmodium knowlesi and Its Inhibition by a Member of δ-Lactone, Hyptolide

Molecules, 2022
The caseinolytic protease (Clp) system plays an essential role in the protein homeostasis of the malaria parasite, particularly at the stage of apicoplast development. The inhibition of this protein is known to have a lethal effect on the parasite and is
Cahyo Budiman, Raimalynah Abd Razak, Angelesa Runin Anak Unggit, Rafida Razali, Meiny Suzery, Ruzaidi Azli Mohd Mokhtar, Ping-Chin Lee, Didik Huswo Utomo   +7 more
doaj   +1 more source

Chemical Inhibition of Pyocyanin Biosynthesis Attenuates Virulence of Pseudomonas aeruginosa

Angewandte Chemie, EarlyView.
Anti‐virulence strategies disarm pathogens rather than killing them directly. A β‐lactone reduces pyocyanin production without affecting growth. Chemical proteomics identified PqsC as the primary target via binding to Cys129. Crystallography revealed the binding mode, and SAR yielded a chloroacetamide inhibitor with improved enzymatic potency and anti ...
Wei Ding, Sebastian R. Borgert, Wulf Blankenfeldt, Stephan A. Sieber   +3 more
wiley   +2 more sources

Efectos de la labranza en la estructura y la actividad biológica a nivel de los microagregados del suelo [PDF]

Ciencia del Suelo, 2018
El conocimiento de la distribución de los microorganismos y la actividad enzimática en las fracciones de agregados del suelo con manejo agrícola puede contribuir a comprender mejor los servicios ecosistémicos del suelo.
Juan Pablo Frene, Luciano Andrés Gabbarini, Luis Gabriel Wall   +2 more
doaj  

CLPP inhibition triggers apoptosis in human ovarian granulosa cells via COX5A abnormality–Mediated mitochondrial dysfunction

Frontiers in Genetics, 2023
Premature ovarian insufficiency (POI) is characterized by early loss of ovarian function before the age of 40 years. It is confirmed to have a strong and indispensable genetic component.
Xiong Yuan, Xiong Yuan, Wenjie Ma, Wenjie Ma, Shuping Chen, Shuping Chen, Huiyuan Wang, Huiyuan Wang, Chenyi Zhong, Chenyi Zhong, Li Gao, Li Gao, Yugui Cui, Yugui Cui, Danhua Pu, Danhua Pu, Rongrong Tan, Rongrong Tan, Jie Wu, Jie Wu   +19 more
doaj   +1 more source

A sensitive soil biological indicator to changes in land-use in regions with Mediterranean climate

Scientific Reports, 2022
The demand for reliable indicators to quantify soil health has increased recently. We propose and test the use of soil microbial functional diversity as an indicator of multifunctional performance in agriculturally important areas. Agricultural fields in
Yosef Steinberger, Alfred Stein, Michael Dorman, Tal Svoray, Tirza Doniger, Oshri Rinot, Eshel Gil   +6 more
doaj   +1 more source

Dysregulating ClpP: From Antibiotics to Anticancer? [PDF]

Cell Chemical Biology, 2018
In this issue of Cell Chemical Biology, Wong et al. (2018) identify several dysregulators of a key mitochondrial protease: casein lytic protease P (ClpP). These dysregulators were found to trigger programmed cell death and may offer fresh avenues for the development of novel cancer therapeutics.
David A, Dougan, Ingo, Hantke, Kürşad, Turgay   +2 more
openaire   +2 more sources

UNDERSTANDING THE ACTIVATION OF BACTERIAL PROTEASE CLPP BY ACYLDEPSIPEPTIDE ANTIBIOTIC [PDF]

, 2014
Acyldepsipeptide (ADEP1) is an antibiotic that binds to Escherichia coli ClpP, mimicking the interaction that the protease typically establishes with ClpA/ClpX ATPases in bacterial cells.
Ahsan, Bilal
core   +1 more source

EXPLORING THE ROLE OF MITOCHONDRIAL PROTEASE CLPP IN APOPTOSIS REGULATION OF TRIPLE NEGATIVE BREAST CANCER CELLS [PDF]

, 2022
Approximately 20% of breast cancer cases diagnosed yearly are of the triple-negative breast cancer (TNBC) type. Current treatments for TNBC patients are limited to surgical intervention and traditional chemotherapies.
Aponte-Collazo, Lucas Josue
core   +1 more source

Quercetin Reduces the Virulence of S. aureus by Targeting ClpP to Protect Mice from MRSA-Induced Lethal Pneumonia

Microbiology Spectrum, 2022
The dramatic increase of methicillin-resistant Staphylococcus aureus (MRSA) poses a great challenge to the treatment of Staphylococcus aureus (S. aureus) infections. Therefore, there is an urgent need to identify novel anti-infective agents to attack new
Shisong Jing, Xiangri Kong, Li Wang, Heming Wang, Jiaxuan Feng, Lin Wei, Ying Meng, Chang Liu, Xiren Chang, Yishen Qu, Jiyu Guan, Haimiao Yang, Chi Zhang, Yicheng Zhao, Wu Song   +14 more
doaj   +1 more source