Results 41 to 50 of about 13,032 (201)

Identification and characterization of approved drugs and drug-like compounds as covalent Escherichia coli ClpP inhibitors [PDF]

, 2019
The serine protease Caseinolytic protease subunit P (ClpP) plays an important role for protein homeostasis in bacteria and contributes to various developmental processes, as well as virulence.
Gribbon, Philip, Winterhalter, Mathias, Windshügel, Björn, Elisa Sassetti, Sassetti, Elisa, Mathias Winterhalter, Philip Gribbon, Tammela, Päivi, Cruz, Cristina Durante, Durante Cruz, Cristina, Tammela, Paeivi, Windshuegel, Bjoern, Koen Augustyns, Päivi Tammela, Augustyns, Koen, Björn Windshügel, Cristina Durante Cruz, Durante Cruz, C., Tammela, P., Augustyns, K., Windshügel, B., Gribbon, P., Sassetti, E., Winterhalter, M.   +23 more
core   +2 more sources

Cellular functions of the ClpP protease impacting bacterial virulence

Frontiers in Molecular Biosciences, 2022
Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent degradation of target substrates.
Mazen E. Aljghami, Marim M. Barghash, Emily Majaesic, Vaibhav Bhandari, Walid A. Houry, Walid A. Houry   +5 more
openaire   +3 more sources

Supplementary Figure S11 from Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis

, 2022
The expression of CLPP and ClpP-targeted enzymes in breast cancer patients and cell ...
Yoshimi Endo Greer (15133724), Binwu Tang (251323), Samuel F. Gilbert (15133733), Lee M. Graves (15133742), Stanley Lipkowitz (15030347), Lidia Hernandez (585095), Edwin Iwanowicz (15133739), Daoud Meerzaman (253200), Emily M.J. Fennell (15133727), Donna Voeller (399951), Thomas S.K. Gilbert (15133736), Manjari Kundu (15133730), Shashikala Ratnayake (5933399), Markus Hafner (14934474), Qingrong Chen (401269), Christina M. Annunziata (15047670), Raj Chari (14950069)   +16 more
core   +1 more source

Mitofusin-2 Down-Regulation Predicts Progression of Non-Muscle Invasive Bladder Cancer

Diagnostics, 2021
Identification of markers predicting disease outcome is a major clinical issue for non-muscle invasive bladder cancer (NMIBC). The present study aimed to determine the role of the mitochondrial proteins Mitofusin-2 (Mfn2) and caseinolytic protease P ...
Antonella Cormio, Gian Maria Busetto, Clara Musicco, Francesca Sanguedolce, Beppe Calò, Marco Chirico, Ugo Giovanni Falagario, Giuseppe Carrieri, Claudia Piccoli, Luigi Cormio   +9 more
doaj   +1 more source

Ein Konformationsschalter ist für die Funktionsweise der Protease ClpP verantwortlich

, 2011
„Atmendes“ Protein: Die erste Struktur des Virulenzregulators und Hitzeschockproteins ClpP aus Staphylococcus aureus mit einem bisher nicht beobachteten komprimierten Zustand des ClpP-Fasses wird vorgestellt.
Stephan A. Sieber, Sieber, Stephan A., Cramer, Patrick, Sebastian R. Geiger, Patrick Cramer, Geiger, Sebastian R., Böttcher, Thomas, Thomas Böttcher   +7 more
core   +1 more source

The ATP-Dependent Protease ClpP Inhibits Biofilm Formation by Regulating Agr and Cell Wall Hydrolase Sle1 in Staphylococcus aureus

Frontiers in Cellular and Infection Microbiology, 2017
Biofilm causes hospital-associated infections on indwelling medical devices. In Staphylococcus aureus, Biofilm formation is controlled by intricately coordinated network of regulating systems, of which the ATP-dependent protease ClpP shows an inhibitory ...
Qian Liu, Xing Wang, Juanxiu Qin, Sen Cheng, Won-Sik Yeo, Lei He, Xiaowei Ma, Xiaoyun Liu, Min Li, Taeok Bae   +9 more
doaj   +1 more source

Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA

Cells, 2021
Biallelic pathogenic variants in CLPP, encoding mitochondrial matrix peptidase ClpP, cause a rare autosomal recessive condition, Perrault syndrome type 3 (PRLTS3). It is characterized by primary ovarian insufficiency and early sensorineural hearing loss,
Jana Key, Sylvia Torres-Odio, Nina C. Bach, Suzana Gispert, Gabriele Koepf, Marina Reichlmeir, A. Phillip West, Holger Prokisch, Peter Freisinger, William G. Newman, Stavit Shalev, Stephan A. Sieber, Ilka Wittig, Georg Auburger   +13 more
doaj   +1 more source

ClpP expression in human cancer.

, 2016
(A and B) Breast adenocarcinoma MCF-7 cells, non-tumorigenic breast epithelial MCF-10A cells (A), or primary human tissue samples representative of normal prostate or prostatic adenocarcinoma (B) were analyzed by western blotting.
M. Cecilia Caino (181113), Hsin-Yao Tang (395357), Dayana B. Rivadeneira (3157134), Jae Ho Seo (3157137), Lucia R. Languino (468911), Young Chan Chae (3157131), David W. Speicher (395361), Paolo Rampini (3157128), Alessandro Palleschi (762698), Silvano Bosari (65835), Dario C. Altieri (183406), Andrew V. Kossenkov (150836), Valentina Vaira (65833)   +12 more
core   +1 more source

A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60

The Journal of Clinical Investigation, 2022
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra   +14 more
doaj   +1 more source

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

eLife, 2020
The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently degrade client proteins.
Zev A Ripstein, Siavash Vahidi, Walid A Houry, John L Rubinstein, Lewis E Kay   +4 more
doaj   +1 more source