Results 41 to 50 of about 10,075 (175)
Journal of Lipid Research, 2004 Apolipoprotein A-I (apoA-I) induces the translocation of newly synthesized cholesterol as well as caveolin-1 to the cytosolic lipid-protein particle (CLPP) fraction in astrocytes before its appearance in high density lipoprotein generated in the medium ...
Jin-ichi Ito +4 more
doaj +1 more source
Open and compressed conformations of Francisella tularensis ClpP
Proteins: Structure, Function, and Bioinformatics, 2016 ABSTRACTCaseinolytic proteases are large oligomeric assemblies responsible for maintaining protein homeostasis in bacteria and in so doing influence a wide range of biological processes. The functional assembly involves three chaperones together with the oligomeric caseinolytic protease catalytic subunit P (ClpP).
Díaz-Sáez, Laura +2 more
openaire +4 more sources
Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress
Interdisciplinary Medicine, EarlyView.This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu +13 more
wiley +1 more source
Chemistry & Biology, 2010 In ClpXP and ClpAP complexes, ClpA and ClpX use the energy of ATP hydrolysis to unfold proteins and translocate them into the self-compartmentalized ClpP protease. ClpP requires the ATPases to degrade folded or unfolded substrates, but binding of acyldepsipeptide antibiotics (ADEPs) to ClpP bypasses this requirement with unfolded proteins.
Li, Dominic Him Shun +9 more
openaire +2 more sources
Discrete Dynamics in Nature and Society, 2021 The effective implementation of cultivated land protection policies (CLPP) has important practical significance for improving China’s food security and ecological security.
Xinhai Lu, Yanwei Zhang, Yucheng Zou
doaj +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo +5 more
wiley +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival
Oncogenesis, 2021 Mitochondrial proteases are key components in mitochondrial stress responses that maintain proteostasis and mitochondrial integrity in harsh environmental conditions, which leads to the acquisition of aggressive phenotypes, including chemoresistance and ...
Yu Geon Lee +8 more
doaj +1 more source
Data in Brief, 2021 Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P.
Raimalynah Abd Razak +6 more
doaj +1 more source
Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling
Cell Proliferation, EarlyView.We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo +4 more
wiley +1 more source