Results 41 to 50 of about 18,307 (208)
Optimization of ClpXP activity and protein synthesis in an E. coli extract-based cell-free expression system. [PDF]
, 2018 Protein degradation is a fundamental process in all living cells and is essential to remove both damaged proteins and intact proteins that are no longer needed by the cell.
Joseph, Simpson +4 more
core +2 more sources
Metabolic Perturbations in a Bacillus subtilis clpP Mutant during Glucose Starvation
Metabolites, 2017 Proteolysis is essential for all living organisms to maintain the protein homeostasis and to adapt to changing environmental conditions. ClpP is the main protease in Bacillus subtilis, and forms complexes with different Clp ATPases.
Daniel Schultz +3 more
doaj +1 more source
Cells, 2021 Biallelic pathogenic variants in CLPP, encoding mitochondrial matrix peptidase ClpP, cause a rare autosomal recessive condition, Perrault syndrome type 3 (PRLTS3). It is characterized by primary ovarian insufficiency and early sensorineural hearing loss,
Jana Key +13 more
doaj +1 more source
Does functional soil microbial diversity contribute to explain within-site plant beta-diversity in an alpine grassland and a dehesa meadow in Spain? [PDF]
, 2017 Questions: Once that the effects of hydrological and chemical soil properties have been accounted for, does soil microbial diversity contribute to explain change in plant community structure (i.e. within-site beta-diversity)?
Araya, Yoseph N. +4 more
core +2 more sources
Comparative algological and bacteriological examinations on biofilms developed on different substrata in a shallow soda lake [PDF]
, 2008 According to the European Water Framework Directives, benthic diatoms of lakes are a tool for ecological status assessment. In this study, we followed an integrative sample analysis approach, in order to find an appropriate substratum for the water ...
A Cattaneo +36 more
core +1 more source
Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis. [PDF]
, 2020 Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis.
Cuevas-Mora, Karina +2 more
core +1 more source
Frontiers in Cellular and Infection Microbiology, 2017 Biofilm causes hospital-associated infections on indwelling medical devices. In Staphylococcus aureus, Biofilm formation is controlled by intricately coordinated network of regulating systems, of which the ATP-dependent protease ClpP shows an inhibitory ...
Qian Liu +9 more
doaj +1 more source
eLife, 2020 The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently degrade client proteins.
Zev A Ripstein +4 more
doaj +1 more source
The Journal of Clinical Investigation, 2022 Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar +14 more
doaj +1 more source
Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP
Pharmacology Research & Perspectives, 2022 We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ...
Emily M. J. Fennell +16 more
doaj +1 more source