Results 41 to 50 of about 13,300 (205)
Targeting the Mitochondrial Protease ClpP for Anticancer Therapy. [PDF]
J Med ChemCancer cells depend on mitochondrial reprogramming for growth, but this raises reactive oxygen species (ROS), increasing reliance on protein quality control (PQC) repair mechanisms. The mitochondrial proteome is maintained through a robust PQC composed of chaperones and proteases, including the mitochondrial matrix protease caseinolytic protease P ...
Xu Z +9 more
europepmc +3 more sources
Nucleic Acids Research, 2023 MTU1 controls intramitochondrial protein synthesis by catalyzing the 2-thiouridine modification of mitochondrial transfer RNAs (mt-tRNAs). Missense mutations in the MTU1 gene are associated with life-threatening reversible infantile hepatic failure ...
Raja Norazireen Raja Ahmad +10 more
semanticscholar +1 more source
Complementation studies with human ClpP in Bacillus subtilis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020 ATP-dependent intracellular proteolysis is essential for all living organisms. ClpP, the proteolytic subunit of the ATP-dependent Clp proteases, shares 56% protein identity between B. subtilis and man. The aim of this study was to verify, whether human ClpP (HClpP) is able to substitute the bacterial pendant, BClpP, irrespectively of the huge ...
Denise, Dittmar +5 more
openaire +2 more sources
A sensitive soil biological indicator to changes in land-use in regions with Mediterranean climate
Scientific Reports, 2022 The demand for reliable indicators to quantify soil health has increased recently. We propose and test the use of soil microbial functional diversity as an indicator of multifunctional performance in agriculturally important areas. Agricultural fields in
Yosef Steinberger +6 more
doaj +1 more source
Journal of Biological Chemistry, 2022 ClpP is a highly conserved serine protease that is a critical enzyme in maintaining protein homeostasis and is an important drug target in pathogenic bacteria and various cancers.
M. Mabanglo, W. Houry
semanticscholar +1 more source
Dysregulating ClpP: From Antibiotics to Anticancer? [PDF]
Cell Chemical Biology, 2018 In this issue of Cell Chemical Biology, Wong et al. (2018) identify several dysregulators of a key mitochondrial protease: casein lytic protease P (ClpP). These dysregulators were found to trigger programmed cell death and may offer fresh avenues for the development of novel cancer therapeutics.
David A, Dougan +2 more
openaire +2 more sources
Efectos de la labranza en la estructura y la actividad biológica a nivel de los microagregados del suelo [PDF]
Ciencia del Suelo, 2018 El conocimiento de la distribución de los microorganismos y la actividad enzimática en las fracciones de agregados del suelo con manejo agrícola puede contribuir a comprender mejor los servicios ecosistémicos del suelo.
Juan Pablo Frene +2 more
doaj
Mitofusin-2 Down-Regulation Predicts Progression of Non-Muscle Invasive Bladder Cancer
Diagnostics, 2021 Identification of markers predicting disease outcome is a major clinical issue for non-muscle invasive bladder cancer (NMIBC). The present study aimed to determine the role of the mitochondrial proteins Mitofusin-2 (Mfn2) and caseinolytic protease P ...
Antonella Cormio +9 more
doaj +1 more source
ClpP inhibitors are produced by a widespread family of bacterial gene clusters
Nature Microbiology, 2022 The caseinolytic protease (ClpP) is part of a highly conserved proteolytic complex whose disruption can lead to antibacterial activity but for which few specific inhibitors have been discovered.
Elizabeth J. Culp +5 more
semanticscholar +1 more source
Metabolic Perturbations in a Bacillus subtilis clpP Mutant during Glucose Starvation
Metabolites, 2017 Proteolysis is essential for all living organisms to maintain the protein homeostasis and to adapt to changing environmental conditions. ClpP is the main protease in Bacillus subtilis, and forms complexes with different Clp ATPases.
Daniel Schultz +3 more
doaj +1 more source