Results 51 to 60 of about 13,300 (205)

Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA

Cells, 2021
Biallelic pathogenic variants in CLPP, encoding mitochondrial matrix peptidase ClpP, cause a rare autosomal recessive condition, Perrault syndrome type 3 (PRLTS3). It is characterized by primary ovarian insufficiency and early sensorineural hearing loss,
Jana Key, Sylvia Torres-Odio, Nina C. Bach, Suzana Gispert, Gabriele Koepf, Marina Reichlmeir, A. Phillip West, Holger Prokisch, Peter Freisinger, William G. Newman, Stavit Shalev, Stephan A. Sieber, Ilka Wittig, Georg Auburger   +13 more
doaj   +1 more source

The ATP-Dependent Protease ClpP Inhibits Biofilm Formation by Regulating Agr and Cell Wall Hydrolase Sle1 in Staphylococcus aureus

Frontiers in Cellular and Infection Microbiology, 2017
Biofilm causes hospital-associated infections on indwelling medical devices. In Staphylococcus aureus, Biofilm formation is controlled by intricately coordinated network of regulating systems, of which the ATP-dependent protease ClpP shows an inhibitory ...
Qian Liu, Xing Wang, Juanxiu Qin, Sen Cheng, Won-Sik Yeo, Lei He, Xiaowei Ma, Xiaoyun Liu, Min Li, Taeok Bae   +9 more
doaj   +1 more source

Potent ClpP agonists with anticancer properties bind the protease with improved structural complementarity and alter the mitochondrial N-terminome

Structure, 2022
SUMMARY The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic processes.
M. Mabanglo, Keith S. Wong, Marim M. Barghash, E. Leung, Stephanie H. W. Chuang, A. Ardalan, Emily Majaesic, Cassandra J. Wong, Shen Zhang, Henk Lang, D. Karanewsky, Andrew A. Iwanowicz, Lee M. Graves, E. Iwanowicz, A. Gingras, W. Houry   +15 more
semanticscholar   +1 more source

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

eLife, 2020
The ClpXP degradation machine consists of a hexameric AAA+ unfoldase (ClpX) and a pair of heptameric serine protease rings (ClpP) that unfold, translocate, and subsequently degrade client proteins.
Zev A Ripstein, Siavash Vahidi, Walid A Houry, John L Rubinstein, Lewis E Kay   +4 more
doaj   +1 more source

Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP

Nature Communications, 2022
The emergence of methicillin-resistant Staphylococcus aureus isolates highlights the urgent need to develop more antibiotics. ClpP is a highly conserved protease regulated by ATPases in bacteria and in mitochondria.
Bingyan Wei, Tao Zhang, Pengyu Wang, Yihui Pan, Jiahui Li, Weizhong Chen, M. Zhang, Q. Ji, Wenjuan Wu, Lefu Lan, J. Gan, Cai-Guang Yang   +11 more
semanticscholar   +1 more source

Apolipoprotein A-I induces translocation of protein kinase Cα to a cytosolic lipid-protein particle in astrocytes

Journal of Lipid Research, 2004
Apolipoprotein A-I (apoA-I) induces the translocation of newly synthesized cholesterol as well as caveolin-1 to the cytosolic lipid-protein particle (CLPP) fraction in astrocytes before its appearance in high density lipoprotein generated in the medium ...
Jin-ichi Ito, Hao Li, Yuko Nagayasu, Alireza Kheirollah, Shinji Yokoyama   +4 more
doaj   +1 more source

A High-Throughput Interbacterial Competition Screen Identifies ClpAP in Enhancing Recipient Susceptibility to Type VI Secretion System-Mediated Attack by Agrobacterium tumefaciens

Frontiers in Microbiology, 2020
The type VI secretion system (T6SS) is an effector delivery system used by Gram-negative bacteria to kill other bacteria or eukaryotic hosts to gain fitness.
Hsiao-Han Lin, Hsiao-Han Lin, Manda Yu, Manoj Kumar Sriramoju, Shang-Te Danny Hsu, Chi-Te Liu, Chi-Te Liu, Erh-Min Lai   +7 more
doaj   +1 more source

Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA–cGAS–STING Signaling Axis

Journal of Immunology, 2021
Key Points IFN-I signaling in CLPP-deficient cells and tissues depends on cGAS and STING. CLPP-deficient cells are resistant to DNA and RNA viruses because of elevated ISGs.
S. Torres-Odio, Yuanjiu Lei, S. Gispert, A. Maletzko, J. Key, Saeed S. Menissy, I. Wittig, G. Auburger, A. West   +8 more
semanticscholar   +1 more source

A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60

The Journal of Clinical Investigation, 2022
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra   +14 more
doaj   +1 more source

ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells

Neoplasia
Highlights • ONC206 induces mitochondria fragmentation and mtROS formation, MMP and ATP depletion, and oxidative stress in HCC cells.• ONC206 elicited apoptosis and protective autophagy and combined with autophagy inhibitor enhanced pro-apoptosis ...
Jiahao Cao, Fei Cao, Chuanzhen Wang, Zhen Jiao, Yuting You, Xiaomin Wang, Wenxiu Zhao   +6 more
semanticscholar   +1 more source