Results 1 to 10 of about 2,558 (137)

Mycobacterial Caseinolytic Protease Gene Regulator ClgR Is a Substrate of Caseinolytic Protease [PDF]

MSphere, 2017
The mycobacterial caseinolytic protease ClpP1P2 is a degradative protease that recently gained interest as a genetically and pharmacologically validated drug target for tuberculosis.
Thomas Dick
exaly   +7 more sources

Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents [PDF]

Cell Reports Medicine
Summary: Methicillin-resistant Staphylococcus aureus is a ubiquitous pathogen, posing a serious threat to human health worldwide. Thus, there is a high demand for antibiotics with distinct targets. Caseinolytic protease P (ClpP) is a promising target for
Cai-Guang Yang
exaly   +6 more sources

Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria [PDF]

mLife
The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens. Its role as a potential drug target for combating tuberculosis (TB) has just begun to be substantiated in ...
Shawn Chen
exaly   +5 more sources

The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis [PDF]

Journal of Biological Chemistry, 2023
Chlamydia trachomatis (ct) is the most reported bacterial sexually transmitted infection worldwide and the leading cause of preventable blindness. Caseinolytic proteases (ClpP) from pathogenic bacteria are attractive antibiotic targets, particularly for bacterial species that form persister colonies with phenotypic resistance against common antibiotics.
Martin Conda-Sheridan, Jahaun Azadmanesh, Scot O   +2 more
exaly   +4 more sources

Plastid caseinolytic protease OsClpR1 regulates chloroplast development and chloroplast RNA editing in rice [PDF]

Rice, 2021
Background Plant plastidic caseinolytic protease (Clp) is a central part of the plastid protease network and consists of multiple subunits. The molecular functions of many Clps in plants, especially in crops, are not well known. Results In this study, we
Xi Liu, Ziyi Xu, Yanrong Yang, Penghui Cao, Hang Cheng, Haiying Zhou   +5 more
doaj   +5 more sources

Substrate Profiling of Mitochondrial Caseinolytic Protease P via a Site‐Specific Photocrosslinking Approach [PDF]

Angewandte Chemie - International Edition, 2022
AbstractApproaches for profiling protease substrates are critical for defining protease functions, but remain challenging tasks. We combine genetic code expansion, photocrosslinking and proteomics to identify substrates of the mitochondrial (mt) human caseinolytic protease P (hClpP). Site‐specific incorporation of the diazirine‐bearing amino acid DiazK
Kathrin Lang, Stephan Sieber, Thomas Gronauer   +2 more
exaly   +7 more sources

Mutations in ClpC1 or ClpX subunit of caseinolytic protease confer resistance to ilamycins in mycobacteria [PDF]

Communications Biology
The mycobacterial caseinolytic protease (Clp) system has been recognized as a promising therapeutic target. In this study, we identify two novel ilamycin analogs, ilamycin E (ILE) and ilamycin F (ILF), both targeting the ClpC1 component of the ClpC1P1P2 ...
Yamin Gao, Cuiting Fang, Biao Zhou, H. M. Adnan Hameed, Changli Sun, Xirong Tian, Jing He, Xingli Han, Han Zhang, Jun Li, Jianhua Ju, Xinwen Chen, Nanshan Zhong, Junying Ma, Xiaoli Xiong, Tianyu Zhang   +15 more
doaj   +4 more sources

Discovery of coniferaldehyde as an inhibitor of caseinolytic protease to combat Staphylococcus aureus infections [PDF]

Molecular Medicine
The rising incidence of methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to global public health, highlighting the urgent need for novel therapies and treatments in clinical settings.
Shufang Li, Yan Zhang, Jianfeng Wang, Hongfa Lv, Hongxia Ma, Lingcong Kong, Yonglin Zhou, Jingmin Gu, Wei Li, Qiaoling Zhang   +9 more
doaj   +4 more sources

Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential [PDF]

Frontiers in Molecular Biosciences, 2021
Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt, Heike Brötz-Oesterhelt, Andreas Vorbach   +2 more
doaj   +5 more sources

Structural and mechanistic insights into caseinolytic protease inhibition for antimicrobial development against Pseudomonas plecoglossicida. [PDF]

PLoS Pathogens
The caseinolytic protease (ClpP) is an emerging antibacterial target. Pseudomonas plecoglossicida (Pp), a pathogen causing visceral white spot disease in Larimichthys crocea, encodes two ClpP paralogs, PpClpP1 and PpClpP2.
Jingjie Chen, Ping Zhang, Hongxin Guan, Bing Gong, Xiaoding Li, Zekai Li, Fan Li, Biao Zhou, Xuemin Chen, Xinhua Chen, Songying Ouyang, Yong-An Zhang   +11 more
doaj   +5 more sources