Results 1 to 10 of about 147,909 (161)

Mycobacterial Caseinolytic Protease Gene Regulator ClgR Is a Substrate of Caseinolytic Protease. [PDF]

MSphere, 2017
The mycobacterial caseinolytic protease ClpP1P2 is a degradative protease that recently gained interest as a genetically and pharmacologically validated drug target for tuberculosis.
Thomas Dick, Yoshiyuki Yamada
exaly   +7 more sources

Technical Data on the Inhibition Properties of Some Medicinal Plant Extracts Towards Caseinolytic Protease Proteolytic Subunit of Plasmodium knowlesi [PDF]

Data in Brief, 2021
Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P.
Ruzaidi Azli Mohd Mokhtar, Meiny Suzery, Cahyo Budiman   +2 more
exaly   +6 more sources

Identification of a Phenyl Ester Covalent Inhibitor of Caseinolytic Protease and Analysis of the ClpP1P2 Inhibition in Mycobacteria [PDF]

mLife
The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens. Its role as a potential drug target for combating tuberculosis (TB) has just begun to be substantiated in ...
Shawn Chen
exaly   +5 more sources

Plastid caseinolytic protease OsClpR1 regulates chloroplast development and chloroplast RNA editing in rice [PDF]

Rice, 2021
Background Plant plastidic caseinolytic protease (Clp) is a central part of the plastid protease network and consists of multiple subunits. The molecular functions of many Clps in plants, especially in crops, are not well known. Results In this study, we
Xi Liu, Ziyi Xu, Yanrong Yang, Penghui Cao, Hang Cheng, Haiying Zhou   +5 more
doaj   +5 more sources

Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents [PDF]

Cell Reports Medicine
Summary: Methicillin-resistant Staphylococcus aureus is a ubiquitous pathogen, posing a serious threat to human health worldwide. Thus, there is a high demand for antibiotics with distinct targets. Caseinolytic protease P (ClpP) is a promising target for
Tao Zhang, Pengyu Wang, Hailing Zhou, Bingyan Wei, Yanling Zhao, Jiahui Li, Min Zhang, Wenjuan Wu, Lefu Lan, Jianhua Gan, Cai-Guang Yang   +10 more
doaj   +4 more sources

Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential [PDF]

Frontiers in Molecular Biosciences, 2021
Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt, Heike Brötz-Oesterhelt, Andreas Vorbach   +2 more
doaj   +5 more sources

Mutations in ClpC1 or ClpX subunit of caseinolytic protease confer resistance to ilamycins in mycobacteria [PDF]

Communications Biology
The mycobacterial caseinolytic protease (Clp) system has been recognized as a promising therapeutic target. In this study, we identify two novel ilamycin analogs, ilamycin E (ILE) and ilamycin F (ILF), both targeting the ClpC1 component of the ClpC1P1P2 ...
Yamin Gao, Cuiting Fang, Biao Zhou, H. M. Adnan Hameed, Changli Sun, Xirong Tian, Jing He, Xingli Han, Han Zhang, Jun Li, Jianhua Ju, Xinwen Chen, Nanshan Zhong, Junying Ma, Xiaoli Xiong, Tianyu Zhang   +15 more
doaj   +4 more sources

Discovery of coniferaldehyde as an inhibitor of caseinolytic protease to combat Staphylococcus aureus infections [PDF]

Molecular Medicine
The rising incidence of methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat to global public health, highlighting the urgent need for novel therapies and treatments in clinical settings.
Shufang Li, Yan Zhang, Jianfeng Wang, Hongfa Lv, Hongxia Ma, Lingcong Kong, Yonglin Zhou, Jingmin Gu, Wei Li, Qiaoling Zhang   +9 more
doaj   +4 more sources

Bortezomib Warhead-Switch Confers Dual Activity Against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity Against Human Proteasome [PDF]

Frontiers in Microbiology, 2017
Mycobacteria harbor two main degradative proteolytic machineries, the caseinolytic protease ClpP1P2 and a proteasome. We recently showed that Bortezomib inhibits ClpP1P2 and exhibits whole cell activity against Mycobacterium tuberculosis.
Brian W Dymock, Thomas Dick, Wilfried Moreira   +2 more
exaly   +4 more sources

Catalytic Properties of Caseinolytic Protease Subunit of Plasmodium knowlesi and Its Inhibition by a Member of δ-Lactone, Hyptolide [PDF]

Molecules, 2022
The caseinolytic protease (Clp) system plays an essential role in the protein homeostasis of the malaria parasite, particularly at the stage of apicoplast development. The inhibition of this protein is known to have a lethal effect on the parasite and is
Cahyo Budiman, Raimalynah Abd Razak, Angelesa Runin Anak Unggit, Rafida Razali, Meiny Suzery, Ruzaidi Azli Mohd Mokhtar, Ping-Chin Lee, Didik Huswo Utomo   +7 more
doaj   +2 more sources