Results 31 to 40 of about 147,909 (161)

Production of mycelial biomass, proteases and protease inhibitors by Ganoderma lucidum under different submerged fermentation conditions [PDF]

Brazilian Journal of Biology, 2023
Ganoderma lucidum is a medicinal mushroom widely recognized as a source of biomolecules with pharmacological properties, however, little is known about the factors that influence the synthesis of bioactive proteins by this fungus when cultivated under ...
V. A. Pessoa, L. B. N. Soares, G. L. Silva, A. S. Vasconcelos, J. F. Silva, J. I. Fariña, S. D. Oliveira-Junior, C. Sales-Campos, L. R. Chevreuil   +8 more
doaj   +1 more source

Hinokiflavone Attenuates the Virulence of Methicillin-Resistant Staphylococcus aureus by Targeting Caseinolytic Protease P. [PDF]

Antimicrob Agents Chemother, 2022
Drug-resistant bacteria was the third leading cause of death worldwide in 2019, which sounds like a cautionary note for global public health. Therefore, developing novel strategies to combat Methicillin-resistant Staphylococcus aureus (MRSA) infections is the need of the hour.
Kong X, Wang B, Chen X, Wang L, Wang X, Hou J, Wei L, Sui L, Zhang C, Guan J, Luan Y, Wang W, Song W, Zhao Y.   +13 more
europepmc   +3 more sources

Knockdown of Adenosine 5'-Triphosphate-Dependent Caseinolytic Protease Proteolytic Subunit 6 Enhances Aluminum Tolerance in Peanut Plants (Arachis hypogea L.). [PDF]

Int J Mol Sci
Aluminum (Al3+) toxicity in acidic soils reduces root growth and can lead to a considerable reduction in peanut plants (Arachis hypogea L.). The caseinolytic protease (Clp) system plays the key role in abiotic stress response.
Shi Y, Zhang D, Liang R, Xiao D, Wang A, He L, Zhan J.   +6 more
europepmc   +2 more sources

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment [PDF]

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +2 more sources

Separation, purification, and phylogenetic characterization of detergent-compatible protease produced by Penicillium species

Medical Journal of Babylon, 2022
Background: Filamentous fungal forms are said to secrete multiple peptidases with portent detergent capabilities in addition to their usage in food, beverages, and pharmaceutical industries.
Omar Sadik Shalal
doaj   +1 more source

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis

Communications Biology, 2023
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria.
Chenxi Guo, Yuan Xiao, Jingkai Gu, Peikun Zhao, Zhe Hu, Jiahuan Zheng, Renwu Hua, Zhuo Hai, Jiaping Su, Jian V. Zhang, William S. B. Yeung, Tianren Wang   +11 more
doaj   +1 more source

Structure-Based Drug Discovery Against the Caseinolytic Protease From Mycobacterium tuberculosis [PDF]

, 2022
Antibacterial drug resistance is a major factor in the increasing rate of failure to successfully treat diseases such as tuberculosis (TB). The World Health Organization estimates that in 2015 a total of 10.4 million new cases of TB were diagnosed.
Tranchina, Emily G
core   +1 more source

Crystal Structure of the Caseinolytic Protease Gene Regulator, a Transcriptional Activator in Actinomycetes [PDF]

Journal of Biological Chemistry, 2009
Human pathogens of the genera Corynebacterium and Mycobacterium possess the transcriptional activator ClgR (clp gene regulator) which in Corynebacterium glutamicum has been shown to regulate the expression of the ClpCP protease genes. ClgR specifically binds to pseudo-palindromic operator regions upstream of clpC and clpP1P2. Here, we present the first
Russo, Santina, Schweitzer, Jens-Eric, Polen, Tino, Bott, Michael, Pohl, Ehmke   +4 more
openaire   +3 more sources

Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo

, 2022
Homo sapiens caseinolytic protease P (HsClpP) plays an important role in maintaining mitochondrial proteostasis. Activating HsClpP has been proved to be a potential strategy for cancer therapy.
Xin Xu (11989), Rao Song (8472771), Jiangnan Zhang (1793173), Zhengyi Dai (5470733), Chengwei Li (181253), Jing Sui (159664), Zhiqiang Qiu (4603993), Youfu Luo (1819777), Shihua Ruan (12624727), Wenliang Qiao (7346561), Tao Yang (184280), Jiasheng Huang (6641330), Baozhu Luo (12624724)   +12 more
core   +3 more sources

Pyrazinamide triggers degradation of its target aspartate decarboxylase

Nature Communications, 2020
It has been shown that the bioactive component of pyrazinamide, pyrazinoic acid (POA), blocks coenzyme A biosynthesis in M. tuberculosis by binding to the aspartate decarboxylase PanD.
Pooja Gopal, Jickky Palmae Sarathy, Michelle Yee, Priya Ragunathan, Joon Shin, Shashi Bhushan, Junhao Zhu, Tatos Akopian, Olga Kandror, Teck Kwang Lim, Martin Gengenbacher, Qingsong Lin, Eric J. Rubin, Gerhard Grüber, Thomas Dick   +14 more
doaj   +1 more source