Results 31 to 40 of about 2,558 (137)

Production of mycelial biomass, proteases and protease inhibitors by Ganoderma lucidum under different submerged fermentation conditions [PDF]

Brazilian Journal of Biology, 2023
Ganoderma lucidum is a medicinal mushroom widely recognized as a source of biomolecules with pharmacological properties, however, little is known about the factors that influence the synthesis of bioactive proteins by this fungus when cultivated under ...
V. A. Pessoa, L. B. N. Soares, G. L. Silva, A. S. Vasconcelos, J. F. Silva, J. I. Fariña, S. D. Oliveira-Junior, C. Sales-Campos, L. R. Chevreuil   +8 more
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Separation, purification, and phylogenetic characterization of detergent-compatible protease produced by Penicillium species

Medical Journal of Babylon, 2022
Background: Filamentous fungal forms are said to secrete multiple peptidases with portent detergent capabilities in addition to their usage in food, beverages, and pharmaceutical industries.
Omar Sadik Shalal
doaj   +1 more source

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis

Communications Biology, 2023
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria.
Chenxi Guo, Yuan Xiao, Jingkai Gu, Peikun Zhao, Zhe Hu, Jiahuan Zheng, Renwu Hua, Zhuo Hai, Jiaping Su, Jian V. Zhang, William S. B. Yeung, Tianren Wang   +11 more
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PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum

Cell Reports, 2017
Summary: The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective.
Anat Florentin, David W. Cobb, Jillian D. Fishburn, Michael J. Cipriano, Paul S. Kim, Manuel A. Fierro, Boris Striepen, Vasant Muralidharan   +7 more
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Pyrazinamide triggers degradation of its target aspartate decarboxylase

Nature Communications, 2020
It has been shown that the bioactive component of pyrazinamide, pyrazinoic acid (POA), blocks coenzyme A biosynthesis in M. tuberculosis by binding to the aspartate decarboxylase PanD.
Pooja Gopal, Jickky Palmae Sarathy, Michelle Yee, Priya Ragunathan, Joon Shin, Shashi Bhushan, Junhao Zhu, Tatos Akopian, Olga Kandror, Teck Kwang Lim, Martin Gengenbacher, Qingsong Lin, Eric J. Rubin, Gerhard Grüber, Thomas Dick   +14 more
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Crystal Structure of the Caseinolytic Protease Gene Regulator, a Transcriptional Activator in Actinomycetes [PDF]

Journal of Biological Chemistry, 2009
Human pathogens of the genera Corynebacterium and Mycobacterium possess the transcriptional activator ClgR (clp gene regulator) which in Corynebacterium glutamicum has been shown to regulate the expression of the ClpCP protease genes. ClgR specifically binds to pseudo-palindromic operator regions upstream of clpC and clpP1P2. Here, we present the first
Russo S, Schweitzer JE, Polen T, Bott M, Pohl E   +4 more
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The plastid caseinolytic protease complex as a model for cytonuclear coevolution

, 2021
Coevolution, or evolution in response to reciprocal selective pressures, is important to biological function and the persistence of populations. Competition or mutualisms between organisms can drive coevolution, as can predatory or parasitic relationships.
Williams, Alissa Marie, author, Sloan, Daniel, advisor, Bedinger, Patricia, committee member, Mueller, Rachel, committee member, Pilon, Marinus, committee member, Stenglein, Mark, committee member   +5 more
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Bacterial caseinolytic proteases as novel targets for antibacterial treatment

International Journal of Medical Microbiology, 2014
Bacterial Clp proteases are important for protein turnover and homeostasis in order to maintain vital cellular functions particularly under stress conditions. Apart from their crucial role in general protein quality control by degrading abnormally folded or otherwise aberrant or malfunctioning proteins, their temporally and spatially precise ...
Heike, Brötz-Oesterhelt, Peter, Sass
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ClpB is an essential stress regulator of Mycobacterium tuberculosis and endows survival advantage to dormant bacilli

International Journal of Medical Microbiology, 2020
The ability to tolerate multiple host derived stresses, resist eradication and persist within the infected individuals is central to the pathogenicity of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB).
Prajna Tripathi, Lalit K. Singh, Sujata Kumari, Owais R. Hakiem, Janendra K. Batra   +4 more
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Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA.

PLoS ONE, 2008
Exported proteases of Helicobacter pylori (H. pylori) are potentially involved in pathogen-associated disorders leading to gastric inflammation and neoplasia. By comprehensive sequence screening of the H. pylori proteome for predicted secreted proteases,
Martin Löwer, Christiane Weydig, Dirk Metzler, Andreas Reuter, Anna Starzinski-Powitz, Silja Wessler, Gisbert Schneider   +6 more
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