Results 11 to 20 of about 147,909 (161)

The Structure of Caseinolytic Protease Subunit ClpP2 Reveals a Functional Model of the Caseinolytic Protease System From Chlamydia trachomatis [PDF]

Journal of Biological Chemistry, 2023
Chlamydia trachomatis (ct) is the most reported bacterial sexually transmitted infection worldwide and the leading cause of preventable blindness. Caseinolytic proteases (ClpP) from pathogenic bacteria are attractive antibiotic targets, particularly for bacterial species that form persister colonies with phenotypic resistance against common antibiotics.
Martin Conda-Sheridan, Jahaun Azadmanesh, Scot O   +2 more
exaly   +4 more sources

Production, Purification, and Biochemical Characterization of a Novel ATP-Dependent Caseinolytic Protease from the Marine Bacterium Cobetia amphilecti KMM 296 [PDF]

Microorganisms
A novel caseinolytic protease (ClpP) of the S14 family from Cobetia amphilecti KMM 296 (CamClpP), comprising 206 amino acids, with a calculated molecular weight of 22.66 kDa and a pI of 4.88, was expressed in Escherichia coli cells to verify the ...
Yulia Noskova, Olga Nedashkovskaya, Larissa Balabanova   +2 more
doaj   +3 more sources

Targeting Human Caseinolytic Protease P (ClpP) as a Novel Therapeutic Strategy in Ovarian Cancer

MedComm – Oncology, 2022
Ovarian cancer (OC) is currently one of the most life‐threatening types of gynecological malignancy with limited treatment options and poor clinical outcomes.
Youfu Luo, Wenliang Qiao, Baozhu Luo
exaly   +3 more sources

Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer. [PDF]

Int J Mol Sci, 2021
Caseinolytic protease P (ClpP) is a mitochondrial serine protease. In mammalian cells, the heterodimerization of ClpP and its AAA+ ClpX chaperone results in a complex called ClpXP, which has a relevant role in protein homeostasis and in maintaining ...
Cormio A, Sanguedolce F, Pesce V, Musicco C.   +3 more
europepmc   +7 more sources

Structural and mechanistic insights into caseinolytic protease inhibition for antimicrobial development against Pseudomonas plecoglossicida. [PDF]

PLoS Pathogens
The caseinolytic protease (ClpP) is an emerging antibacterial target. Pseudomonas plecoglossicida (Pp), a pathogen causing visceral white spot disease in Larimichthys crocea, encodes two ClpP paralogs, PpClpP1 and PpClpP2.
Jingjie Chen, Ping Zhang, Hongxin Guan, Bing Gong, Xiaoding Li, Zekai Li, Fan Li, Biao Zhou, Xuemin Chen, Xinhua Chen, Songying Ouyang, Yong-An Zhang   +11 more
doaj   +5 more sources

Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis [PDF]

Nature Communications
The caseinolytic protease (Clp) system has recently emerged as a promising anti-tuberculosis target. The anti-cancer drug bortezomib exhibits potent anti-mycobacterial activity and binds to Mycobacterium tuberculosis (Mtb) Clp protease complexes.
Biao Zhou, Yamin Gao, Heyu Zhao, Banghui Liu, Han Zhang, Cuiting Fang, Hang Yuan, Jingjing Wang, Zimu Li, Yi Zhao, Xiaodong Huang, Xiyue Wang, A. Sofia. F. Oliveira, James Spencer, Adrian J. Mulholland, Steven G. Burston, Jinxing Hu, Ning Su, Xinwen Chen, Jun He, Tianyu Zhang, Xiaoli Xiong   +21 more
doaj   +5 more sources

Substrate Profiling of Mitochondrial Caseinolytic Protease P via a Site-Specific Photocrosslinking Approach [PDF]

Angewandte Chemie - International Edition, 2022
AbstractApproaches for profiling protease substrates are critical for defining protease functions, but remain challenging tasks. We combine genetic code expansion, photocrosslinking and proteomics to identify substrates of the mitochondrial (mt) human caseinolytic protease P (hClpP). Site‐specific incorporation of the diazirine‐bearing amino acid DiazK
Kathrin Lang, Stephan A. Sieber, Thomas F Gronauer   +2 more
exaly   +7 more sources

The caseinolytic protease complex component CLPC1 in Arabidopsis maintains proteome and RNA homeostasis in chloroplasts [PDF]

BMC Plant Biology, 2018
Background Homeostasis of the proteome is critical to the development of chloroplasts and also affects the expression of certain nuclear genes. CLPC1 facilitates the translocation of chloroplast pre-proteins and mediates protein degradation.
Shoudong Zhang, Huoming Zhang, Yiji Xia, Liming Xiong   +3 more
doaj   +6 more sources

Target Mechanism-Based Whole-Cell Screening Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria [PDF]

mBio, 2015
A novel type of antibacterial screening method, a target mechanism-based whole-cell screening method, was developed to combine the advantages of target mechanism- and whole-cell-based approaches. A mycobacterial reporter strain with a synthetic phenotype
Wilfried Moreira, Grace J. Y. Ngan, Jian Liang Low, Anders Poulsen, Brian C. S. Chia, Melgious J. Y. Ang, Amelia Yap, Justina Fulwood, Umayal Lakshmanan, Jolander Lim, Audrey Y. T. Khoo, Horst Flotow, Jeffrey Hill, Ravikiran M. Raju, Eric J. Rubin, Thomas Dick   +15 more
doaj   +7 more sources

Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P. [PDF]

J Nat Prod, 2016
Caseinolytic protease P (ClpP) maintains essential roles in bacterial homeostasis. As such, both the inhibition and activation of this enzyme result in bactericidal activity, making ClpP a promising target for antibacterial drug development.
Lavey NP, Coker JA, Ruben EA, Duerfeldt AS.   +3 more
europepmc   +5 more sources