Results 41 to 50 of about 4,619 (182)

Production of mycelial biomass, proteases and protease inhibitors by Ganoderma lucidum under different submerged fermentation conditions [PDF]

Brazilian Journal of Biology, 2023
Ganoderma lucidum is a medicinal mushroom widely recognized as a source of biomolecules with pharmacological properties, however, little is known about the factors that influence the synthesis of bioactive proteins by this fungus when cultivated under ...
V. A. Pessoa, L. B. N. Soares, G. L. Silva, A. S. Vasconcelos, J. F. Silva, J. I. Fariña, S. D. Oliveira-Junior, C. Sales-Campos, L. R. Chevreuil   +8 more
doaj   +1 more source

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +4 more sources

Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis. [PDF]

Antimicrob Agents Chemother, 2017
Yee M, Gopal P, Dick T.
europepmc   +2 more sources

Separation, purification, and phylogenetic characterization of detergent-compatible protease produced by Penicillium species

Medical Journal of Babylon, 2022
Background: Filamentous fungal forms are said to secrete multiple peptidases with portent detergent capabilities in addition to their usage in food, beverages, and pharmaceutical industries.
Omar Sadik Shalal
doaj   +1 more source

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis

Communications Biology, 2023
Caseinolytic protease proteolytic subunit (ClpP) and caseinolytic protease X (ClpX) are mitochondrial matrix peptidases that activate mitochondrial unfolded protein response to maintain protein homeostasis in the mitochondria.
Chenxi Guo, Yuan Xiao, Jingkai Gu, Peikun Zhao, Zhe Hu, Jiahuan Zheng, Renwu Hua, Zhuo Hai, Jiaping Su, Jian V. Zhang, William S. B. Yeung, Tianren Wang   +11 more
doaj   +1 more source

Human μ-calpain: Simple isolation from erythrocytes and characterization of autolysis fragments [PDF]

, 2001
Heterodimeric μ-calpain, consisting of the large (80 kDa) and the small (30 kDa) subunit, was isolated and purified from human erythrocytes by a highly reproducible four-step purification procedure.
Crawford C., Croall D. E., Graham-Siegenthaler K., Guroff G., Kitahara A., McClelland P., Nishimura T., Sasaki T., Sorimachi H., Sorimachi H., Sorimachi H., Thompson V.F., Yoshimura N., Zimmermann U.J.P.   +13 more
core   +1 more source

PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum

Cell Reports, 2017
Summary: The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective.
Anat Florentin, David W. Cobb, Jillian D. Fishburn, Michael J. Cipriano, Paul S. Kim, Manuel A. Fierro, Boris Striepen, Vasant Muralidharan   +7 more
doaj   +1 more source

Pyrazinamide triggers degradation of its target aspartate decarboxylase

Nature Communications, 2020
It has been shown that the bioactive component of pyrazinamide, pyrazinoic acid (POA), blocks coenzyme A biosynthesis in M. tuberculosis by binding to the aspartate decarboxylase PanD.
Pooja Gopal, Jickky Palmae Sarathy, Michelle Yee, Priya Ragunathan, Joon Shin, Shashi Bhushan, Junhao Zhu, Tatos Akopian, Olga Kandror, Teck Kwang Lim, Martin Gengenbacher, Qingsong Lin, Eric J. Rubin, Gerhard Grüber, Thomas Dick   +14 more
doaj   +1 more source

Vibrio proteases for biomedical applications: Modulating the proteolytic secretome of v. alginolyticus and v. parahaemolyticus for improved enzymes production [PDF]

, 2019
Proteolytic enzymes are of great interest for biotechnological purposes, and their large-scale production, as well as the discovery of strains producing new molecules, is a relevant issue.
Ghersi G., Nicosia A., Salamone M., Tagliavia M.   +3 more
core   +1 more source

Removal of luminal content protects the small intestine during hemorrhagic shock but is not sufficient to prevent lung injury. [PDF]

, 2013
The small intestine plays a key role in the pathogenesis of multiple organ failure following circulatory shock. Current results show that reduced perfusion of the small intestine compromises the mucosal epithelial barrier, and the intestinal contents ...
Altshuler, Angelina E, Heller, Michael J, Modestino, Augusta E, Penn, Alexander H, Richter, Michael D, Schmid-Schönbein, Geert W   +5 more
core   +2 more sources