Results 61 to 70 of about 147,909 (161)

The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism

Redox Biology
Vascular smooth muscle cells (VSMCs), known for their remarkable lifelong phenotypic plasticity, play a pivotal role in vascular pathologies through their ability to transition between different phenotypes. Our group discovered that the deficiency of the
Felipe Paredes, Holly C. Williams, Xuesong Liu, Claire Holden, Bethany Bogan, Yu Wang, Kathryn M. Crotty, Samantha M. Yeligar, Alvaro A. Elorza, Zhiyong Lin, Amir Rezvan, Alejandra San Martin   +11 more
doaj   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Applicability Assessment of a Microbial Proteolytic Fermentation Broth to Leather Processing and Protein Stain Removal

Applied Sciences
Microbial proteases are fundamental towards the eco-sustainability of proteolysis at the industrial scale. A proteolytic broth was obtained from a bioreactor fermentation of a proteolytic Bacillus strain isolated from an industrial alkaline bath.
Manuela Lageiro, Maria João Moura, Fernanda Simões, Nuno Alvarenga, Alberto Reis   +4 more
doaj   +1 more source

A study on trypsin, Aspergillus flavus and Bacillus sp. protease inhibitory activity in Cassia tora (L.) syn Senna tora (L.) Roxb. seed extract

BMC Complementary and Alternative Medicine, 2011
Background Proteases play an important role in virulence of many human, plant and insect pathogens. The proteinaceous protease inhibitors of plant origin have been reported widely from many plant species.
Garg Satyendra K, Kumar Shailendra, Tripathi Vinayak R   +2 more
doaj   +1 more source

Purification And Characterization Of Protease From Artocarpus Integer Leaf [PDF]

, 2012
The presence of a protease in Artocarpus integer leaves, which can be used as a meat tenderiser, was verified by the presence of a band at 69 kDa, using caseinolytic zymography and sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS PAGE ...
Zulfigar,, Siti Balqis
core   +1 more source

An antibiotic, heavy metal resistant and halotolerant Bacillus cereus SIU1 and its thermoalkaline protease

Microbial Cell Factories, 2010
Background Many workers have reported halotolerant bacteria from saline conditions capable of protease production. However, antibiotic resistance and heavy metal tolerance pattern of such organisms is not documented very well.
Vikram Surendra, Jain Rakesh K, Tripathi Vinayak R, Singh Sanjay K, Garg Satyendra K   +4 more
doaj   +1 more source

Dordaviprone Maintenance After Allogeneic HCT for High‐Risk Acute Myeloid Leukemia and Myelodysplastic Neoplasm

American Journal of Hematology, Volume 101, Issue 9, Page 2288-2296, September 2026.
ABSTRACT Dordaviprone is a first‐in‐class small‐molecule imipridone. In preclinical studies, it is active against leukemia cells harboring a TP53 mutation or complex karyotype and leukemia stem cells while sparing normal bone marrow cells. This study aimed to determine the safety of dordaviprone maintenance after allogeneic hematopoietic cell ...
Vijaya Raj Bhatt, Christopher S. Wichman, Alyssa Bouska, Moataz Ellithi, Michael Haddadin, Javeed Iqbal, James E. Talmadge, Lori J. Maness, Krishna Gundabolu   +8 more
wiley   +1 more source

Multipotential Alkaline Protease From a Novel Pyxidicoccus sp. 252: Ecofriendly Replacement to Various Chemical Processes

Frontiers in Microbiology, 2021
A newly isolated alkaline protease-producing myxobacterium was isolated from soil. The strain was identified as Pyxidicoccus sp. S252 on the basis of 16S rRNA sequence analysis.
Sonia Sharma, Shiv Kumar, Rajinder Kaur, Ramandeep Kaur   +3 more
doaj   +1 more source

Production of an alkaline protease usingBacillus pumilusD3 without inactivation by SDS, its characterization and purification

, 2013
In this study, protease-producing capacity of Bacillus pumilus D3, isolated from hydrocarbon contaminated soil, was evaluated and optimized. Optimum growing conditions for B.
Yardımcı, Ezgi, Çalışkan, Figen, Çabuk, Ahmet, Ahmet Çabuk, Aytar, Pınar, Pınar Aytar, Gedikli, Serap, Burçin Özçelik, Ezgi Yardımcı, Figen Çalışkan, Özçelik, Burçin, Serap Gedikli, ÇALIŞKAN, FİGEN, AYTAR ÇELİK, PINAR, Yardimci, Ezgi   +14 more
core   +1 more source

Lipopeptides as dimerization inhibitors of HIV-1 protease [PDF]

, 1999
In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g, HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs, An alternative ...
Schramm, W., Schramm, H. J., Büttner, J., de Rosny, E., Dick, A., Reboud-Ravaux, M.   +5 more
core   +1 more source