Results 51 to 60 of about 147,909 (161)
Acyldepsipeptide Analogues: A Future Generation Antibiotics for Tuberculosis Treatment
Pharmaceutics, 2022 Acyldepsipeptides (ADEPs) are a new class of emerging antimicrobial peptides (AMPs), which are currently explored for treatment of pathogenic infections, including tuberculosis (TB). These cyclic hydrophobic peptides have a unique bacterial target to the
Sinazo Z. Z. Cobongela +3 more
doaj +1 more source
Elucidating the Molecular Impact of DA29‐Induced ClpP Chemoactivation on Mitochondrial Function [PDF]
FASEB JA promising approach to tackling DIPG, a lethal pediatric brain tumor, relies on small molecules capable of activating the human mitochondrial protease hClpP. The novel piperazine‐based compound DA29 specifically activates endogenous hClpP, thereby compromising mtDNA levels, mitoribosomes, and OXPHOS complex subunits.
Rizzo F +5 more
europepmc +2 more sources
CASEINOLYTIC ACTIVITY OF HUMAN MYCOPLASMAS [PDF]
, 1978 Caseinolytic activity was found to exist in Mycoplasma salivarium, M. orale l, W. orale 2, M. orale 3, M. hominis, M. fermentans, M.
Takahiro, HORIKAWA, Tsuguo, WATANABE
core +1 more source
Gut microbiota as a novel therapeutic target for eating disorders and obesity
British Journal of Pharmacology, EarlyView.The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė +5 more
wiley +1 more source
The proteolytic activity of Listeria monocytogenes HtrA
BMC Microbiology, 2019 Background High temperature requirement A (HtrA) is a widely expressed chaperone and serine protease in bacteria. HtrA proteases assemble and hydrolyze misfolded proteins to enhance bacterial survival under stress conditions.
Carmen M. Abfalter +5 more
doaj +1 more source
mBio, 2022 Clp proteases consist of a proteolytic, tetradecameric ClpP core and AAA+ Clp-ATPases. Streptomycetes, producers of a plethora of secondary metabolites, encode up to five different ClpP homologs, and the composition of their unusually complex Clp ...
Laura Reinhardt +7 more
doaj +1 more source
Development of Small Molecule Activators of Caseinolytic Protease P [PDF]
, 2014 Caseinolytic protease (ClpP) is a cylindrical protease that degrades proteins in the presence of ATPase chaperones. On its own, bacterial ClpP can only degrade small peptides; however, the addition of a novel class of antibiotics, ADEPs, can cause ...
Nhieu, Alan
core
Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad [PDF]
Proceedings of the National Academy of Sciences, 2013 Caseinolytic proteases (ClpPs) are large oligomeric protein complexes that contribute to cell homeostasis as well as virulence regulation in bacteria. Although most organisms possess a single ClpP protein, some organisms encode two or more ClpP isoforms. Here, we elucidated the crystal structures of ClpP1 and ClpP2 from pathogenic
Zeiler, Evelyn +8 more
openaire +4 more sources
Embryonal degreening and seed longevity require plastid LEA proteins
New Phytologist, EarlyView.Working model of how plastidial LEA proteins aid the remodelling of photosynthetic structures during degreening of Arabidopsis seed embryos. LEA42 and LEA48 support thylakoid proteostasis and membrane remodelling in embryonal cells during late seed maturation by maintaining a local physicochemical environment compatible with protein turnover and ...
Dennis Brandt +17 more
wiley +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang +10 more
wiley +1 more source