The Serine Protease-Serine Protease Inhibitor Regulatory Network in Inflammatory Bowel Disease: From Molecular Mechanisms to Novel Therapeutic Horizons [PDF]
Journal of Advanced ResearchBackground: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that presents a significant global health challenge.
Qinrong Li +4 more
doaj +2 more sources
Characterization of a novel Mycobacterium tuberculosis serine protease Rv1815 in regulating bacterial metabolism and macrophage intracellular survival [PDF]
Current Research in Microbial SciencesThe serine proteases of Mycobacterium tuberculosis (Mtb) are critical contributors to bacterial invasion and pathogenesis. In this study, we characterized the role of a novel serine protease Rv1815 in Mtb.
Qishun Feng +7 more
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Serine proteases, their inhibitors and allergy [PDF]
Allergy: European Journal of Allergy and Clinical Immunology, 2006 This paper reviews four serine protease inhibitors and three protease gene defects that are associated with allergic conditions, suggesting an important role for these genes and their products in the development of allergy. Serine protease inhibitors may have a therapeutic potential in the treatment of allergy.
J I Harper
exaly +3 more sources
Heliyon, 2021 In this study, we have isolated and characterized proteolytic soil bacteria and their alkaline protease. Based on 16S rRNA sequence analysis, 12 isolates with the highest protease activity were classified as B. subtilis and B. cereus groups. B.
Amal Mahmoud +5 more
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Dual function of a bee venom serine protease: prophenoloxidase-activating factor in arthropods and fibrin(ogen)olytic enzyme in mammals. [PDF]
PLoS ONE, 2010 Bee venom contains a variety of peptides and enzymes, including serine proteases. While the presence of serine proteases in bee venom has been demonstrated, the role of these proteins in bee venom has not been elucidated.
Young Moo Choo +11 more
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Novel inhibitors and activity-based probes targeting serine proteases
Frontiers in Chemistry, 2022 Serine proteases play varied and manifold roles in important biological, physiological, and pathological processes. These include viral, bacterial, and parasitic infection, allergic sensitization, tumor invasion, and metastasis. The use of activity-based
Timothy E. G. Ferguson +3 more
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Journal of Integrative Agriculture, 2023 The serine proteases of Mycobacteria tuberculosis (Mtb) are important contributors to the process of bacterial invasion and its pathogenesis. In the present study, we systematically characterized the role of the Rv1043c protein in Mycobacterium infection
Yang-yang TANG +6 more
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BIO Web of Conferences, 2020 This research aims to investigate the HtrA1 serine protease circulating level of Age-related Macular Degeneration (AMD) patients in Yogyakarta, Indonesia.
Supanji Supanji +9 more
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New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina
BMC Evolutionary Biology, 2010 Background Subtilisin-like serine proteases play an important role in pathogenic fungi during the penetration and colonization of their hosts. In this study, we perform an evolutionary analysis of the subtilisin-like serine protease genes of subphylum ...
Zhang Ying +9 more
doaj +1 more source
Alveolar macrophages play a key role in cockroach-induced allergic inflammation via TNF-α pathway. [PDF]
PLoS ONE, 2012 The activity of the serine protease in the German cockroach allergen is important to the development of allergic disease. The protease-activated receptor (PAR)-2, which is expressed in numerous cell types in lung tissue, is known to mediate the cellular ...
Joo Young Kim +6 more
doaj +1 more source