Characterization of a novel Mycobacterium tuberculosis serine protease Rv1815 in regulating bacterial metabolism and macrophage intracellular survival [PDF]
Current Research in Microbial SciencesThe serine proteases of Mycobacterium tuberculosis (Mtb) are critical contributors to bacterial invasion and pathogenesis. In this study, we characterized the role of a novel serine protease Rv1815 in Mtb.
Qishun Feng +7 more
doaj +2 more sources
Heliyon, 2021 In this study, we have isolated and characterized proteolytic soil bacteria and their alkaline protease. Based on 16S rRNA sequence analysis, 12 isolates with the highest protease activity were classified as B. subtilis and B. cereus groups. B.
Amal Mahmoud +5 more
doaj +1 more source
Dual function of a bee venom serine protease: prophenoloxidase-activating factor in arthropods and fibrin(ogen)olytic enzyme in mammals. [PDF]
PLoS ONE, 2010 Bee venom contains a variety of peptides and enzymes, including serine proteases. While the presence of serine proteases in bee venom has been demonstrated, the role of these proteins in bee venom has not been elucidated.
Young Moo Choo +11 more
doaj +1 more source
Novel inhibitors and activity-based probes targeting serine proteases
Frontiers in Chemistry, 2022 Serine proteases play varied and manifold roles in important biological, physiological, and pathological processes. These include viral, bacterial, and parasitic infection, allergic sensitization, tumor invasion, and metastasis. The use of activity-based
Timothy E. G. Ferguson +3 more
doaj +1 more source
Journal of Integrative Agriculture, 2023 The serine proteases of Mycobacteria tuberculosis (Mtb) are important contributors to the process of bacterial invasion and its pathogenesis. In the present study, we systematically characterized the role of the Rv1043c protein in Mycobacterium infection
Yang-yang TANG +6 more
doaj +1 more source
BIO Web of Conferences, 2020 This research aims to investigate the HtrA1 serine protease circulating level of Age-related Macular Degeneration (AMD) patients in Yogyakarta, Indonesia.
Supanji Supanji +9 more
doaj +1 more source
Alveolar macrophages play a key role in cockroach-induced allergic inflammation via TNF-α pathway. [PDF]
PLoS ONE, 2012 The activity of the serine protease in the German cockroach allergen is important to the development of allergic disease. The protease-activated receptor (PAR)-2, which is expressed in numerous cell types in lung tissue, is known to mediate the cellular ...
Joo Young Kim +6 more
doaj +1 more source
New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina
BMC Evolutionary Biology, 2010 Background Subtilisin-like serine proteases play an important role in pathogenic fungi during the penetration and colonization of their hosts. In this study, we perform an evolutionary analysis of the subtilisin-like serine protease genes of subphylum ...
Zhang Ying +9 more
doaj +1 more source
Preliminary investigations on the serine and aspartic protease inhibitors from Nothopegia beddomei
Ceylon Journal of Science, 2019 Aqueous stem bark extract of Nothopegia beddomei was assayed for serine and aspartic protease inhibitors by using trypsin and pepsin as the target enzymes, respectively. Crude bark extract was dialyzed and subjected to inhibition assays.
M.G.K.P. Dayarathne, Sanath Rajapakse
doaj +1 more source
Identification and characterization of fusolisin, the Fusobacterium nucleatum autotransporter serine protease. [PDF]
PLoS ONE, 2014 Fusobacterium nucleatum is an oral anaerobe associated with periodontal disease, adverse pregnancy outcomes and colorectal carcinoma. A serine endopeptidase of 61-65 kDa capable of damaging host tissue and of inactivating immune effectors was detected ...
Lior Doron +6 more
doaj +1 more source