Results 11 to 20 of about 491,498 (207)

Repurposed Single Inhibitor for Serine Protease and Spike Glycoproteins of SAR-CoV-2 [PDF]

, 2020
In this research, structure of SARS-CoV-2 spike glycoprotein S1 and S2 along with TMPRSS2, TMPRSS4, TMPRSS11A, TMPRSS11D and TMPRSS11E serine protease (which activates S1 and S2) are used for docking with repurposed inhibitor drug molecules.
Mohtasheemul, Hassan, Tanzila, Arshad, Hamdullah, Khadim Sheikh, Iqra, Arshad, Zainab Sher, Mohammad   +4 more
core   +1 more source

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
O\u27Brien, Pamela, O'Brien, Pamela, O'Connor, Brendan, O\u27Connor, Brendan   +3 more
core   +2 more sources

Preliminary investigations on the serine and aspartic protease inhibitors from Nothopegia beddomei

Ceylon Journal of Science, 2019
Aqueous stem bark extract of Nothopegia beddomei was assayed for serine and aspartic protease inhibitors by using trypsin and pepsin as the target enzymes, respectively. Crude bark extract was dialyzed and subjected to inhibition assays.
M.G.K.P. Dayarathne, Sanath Rajapakse
doaj   +1 more source

T-SP1: a novel serine protease-like protein predominantly expressed in testis [PDF]

, 2008
Here, we describe a novel member in the group of membrane-anchored chymotrypsin (S1)-like serine proteases, namely testis serine protease 1 (T-SP1), as it is principally expressed in testis tissue.
Nerlich, Andreas, Profanter, Birgit, Geissler, Claudia, Neth, Peter, Sommerhoff, Christian P., Naegler, Dorit K., Jochum, Marianne   +6 more
core   +1 more source

The Effect of Serine Protease Inhibitors on Visceral Pain in Different Rodent Models With an Intestinal Insult

Frontiers in Pharmacology, 2022
Background: Serine proteases are believed to play a key role in the origin of abdominal pain in IBD and IBS. We previously demonstrated a reduction of visceral pain in a post-inflammatory IBS rat model after a single intraperitoneal or intracolonic ...
Hannah Ceuleers, Hannah Ceuleers, Hannah Ceuleers, Nikita Hanning, Nikita Hanning, Michelle De bruyn, Michelle De bruyn, Joris G De Man, Joris G De Man, Heiko U De Schepper, Heiko U De Schepper, Heiko U De Schepper, Qian Li, Liansheng Liu, Steven Abrams, Steven Abrams, Annemieke Smet, Annemieke Smet, Jurgen Joossens, Koen Augustyns, Koen Augustyns, Ingrid De Meester, Ingrid De Meester, Pankaj J Pasricha, Benedicte Y De Winter, Benedicte Y De Winter, Benedicte Y De Winter   +26 more
doaj   +1 more source

The hyaluronan-binding serine protease from human plasma cleaves HMW and LMW kininogen and releases bradykinin [PDF]

, 2002
The influence of the hyaluronanbinding protease (PHBSP), a plasma enzyme with FVII- and pro-urokinase-activating potency, on components of the contact phase (kallikrein/kinin) system was investigated.
Fink, E., Beer, N., Etscheid, M., Dodt, J., Seitz, R.   +4 more
core   +1 more source

Identification and characterization of fusolisin, the Fusobacterium nucleatum autotransporter serine protease. [PDF]

PLoS ONE, 2014
Fusobacterium nucleatum is an oral anaerobe associated with periodontal disease, adverse pregnancy outcomes and colorectal carcinoma. A serine endopeptidase of 61-65 kDa capable of damaging host tissue and of inactivating immune effectors was detected ...
Lior Doron, Shunit Coppenhagen-Glazer, Yara Ibrahim, Amir Eini, Ronit Naor, Graciela Rosen, Gilad Bachrach   +6 more
doaj   +1 more source

Gadolinium-Cyclic 1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetic Acid-Click-Sulfonyl Fluoride for Probing Serine Protease Activity in Magnetic Resonance Imaging

Molecules, 2023
Serine protease is linked to a wide range of diseases, prompting the development of robust, selective, and sensitive protease assays and sensing methods.
Phuong Tu Huynh, Huy Duc Vu, Junghwa Ryu, Hee Su Kim, Hoesu Jung, Sung Won Youn   +5 more
doaj   +1 more source

Serine proteases [PDF]

IUBMB Life, 2009
AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
openaire   +3 more sources

Optimization of the Conditions for Extraction of Serine Protease from Kesinai Plant (Streblus asper) Leaves Using Response Surface Methodology

Molecules, 2011
Response surface methodology (RSM) using a central composite design (CCD) was employed to optimize the conditions for extraction of serine protease from kesinai (Streblus asper) leaves.
Md. Zaidul Islam Sarker, Abdul Manap Mohd Yazid, Shuhaimi Mustafa, Amid Mehrnoush   +3 more
doaj   +1 more source