Results 21 to 30 of about 491,498 (207)

Serine Proteases in Rodent Hippocampus [PDF]

Journal of Biological Chemistry, 1998
Brain serine proteases are implicated in developmental processes, synaptic plasticity, and in disorders including Alzheimer's disease. The spectrum of the major enzymes expressed in brain has not been established previously. We now present a systematic study of the serine proteases expressed in adult rat and mouse hippocampus.
Davies, Ben J., Pickard, Benjamin S., Steel, Muriel, Morris, Richard G. M., Lathe, Richard   +4 more
openaire   +4 more sources

In vitro characterization of jellyfish venom fibrin(ogen)olytic enzymes from Nemopilema nomurai

Journal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background Because jellyfish are capable of provoking envenomation in humans, they are considered hazardous organisms. Although the effects of their toxins are a matter of concern, information on the venom components, biological activity and pathological
Seong Kyeong Bae, Hyunkyoung Lee, Yunwi Heo, Min Jung Pyo, Indu Choudhary, Chang Hoon Han, Won Duk Yoon, Changkeun Kang, Euikyung Kim   +8 more
doaj   +1 more source

Malarial proteases and host cell egress: an 'emerging' cascade. [PDF]

, 2008
Malaria is a scourge of large swathes of the globe, stressing the need for a continuing effort to better understand the biology of its aetiological agent. Like all pathogens of the phylum Apicomplexa, the malaria parasite spends part of its life inside a
Blackman, Michael J
core   +1 more source

Purification and characterization of novel fibrinolytic proteases as potential antithrombotic agents from earthworm Perionyx excavatus [PDF]

, 2011
Six protease fractions, namely FI, FII, FIII-1, FIII-2, FIII-3 and FIV, were isolated from Perionyx excavatus earthworm biomass by acetone precipitation, followed by serial chromatography using anion exchange, hydrophobic interaction and size exclusion ...
Giang Duong, Tien Duy Ta, phan, T.T.B., Tram Phan, Tram Thi Bich Phan, Dung Nguyen, Broek, L.A.M., van den, Dung Thi Xuan Nguyen, Giang Thi Huong Duong, Tien Ta, van den Broek, L.A.M., Ta, T.D., Lambertus AM Van Den Broek, Nguyen, D.T.X.   +13 more
core   +1 more source

Comparative evolutionary histories of fungal proteases reveal gene gains in the mycoparasitic and nematode-parasitic fungus Clonostachys rosea

BMC Evolutionary Biology, 2018
Background The ascomycete fungus Clonostachys rosea (order Hypocreales) can control several important plant diseases caused by plant pathogenic fungi and nematodes. Subtilisin-like serine proteases are considered to play an important role in pathogenesis
Mudassir Iqbal, Mukesh Dubey, Mikael Gudmundsson, Maria Viketoft, Dan Funck Jensen, Magnus Karlsson   +5 more
doaj   +1 more source

Identification of a Novel Thermostable Alkaline Protease from Bacillus megaterium-TK1 for the Detergent and Leather Industry

Biology, 2020
An increased need by the green industry for enzymes that can be exploited for eco-friendly industrial applications led us to isolate and identify a unique protease obtained from a proteolytic Bacillus megaterium-TK1 strain from a seawater source.
Tamilvendan Manavalan, Arulmani Manavalan, Shiyamsundar Ramachandran, Klaus Heese   +3 more
doaj   +1 more source

Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus [PDF]

, 2008
Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This trial revealed residue mutations that confer varying degrees of
Stefan Zeuzem, Albrecht, M., Hartmann, Christoph, Mayr, G., Andreas Schlicker, Welsch, C., Sarrazin, C., Susser, Simone, Sarrazin, Christoph, Lengauer, T., Albrecht, Mario, Christoph Welsch, Thomas Lengauer, Christoph Sarrazin, Antes, I., Mayr, Gabriele, Iris Antes, Simone Susser, Gabriele Mayr, Lengauer, Thomas, Susser, S., Zeuzem, S., Hartmann, C., Christoph Hartmann, Mario Albrecht, Schlicker, A., Francisco S Domingues, Domingues, Francisco S., Domingues, F., Welsch, Christoph, Schlicker, Andreas, Antes, Iris, Zeuzem, Stefan   +32 more
core   +1 more source

Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]

, 2010
Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Burkhart, Julia M., Schwarz, Amelie, Christian Ries, Utzschneider, Daniel, Karolina Plaza, Debela, M., Amelie Schwarz, Plaza, Karolina, Beaufort, Nathalie, Creutzburg, Sabine, Ries, C., Schmitt, M., Burkhart, J. M., Beaufort, N., Plaza, K., Ries, Christian, Schwarz, A., Sabine Creutzburg, Mekdes Debela, Creutzburg, S., Schmitt, Manfred, Utzschneider, D., Julia M. Burkhart, Magdolen, Viktor, Debela, Mekdes, Viktor Magdolen, Nathalie Beaufort, Magdolen, V., Beaufort, N;Plaza, K;Utzschneider, D;Schwarz, A;Burkhart, JM;Creutzburg, S;Debela, M;Schmitt, M;Ries, C;Magdolen, V   +28 more
core   +1 more source

Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8 [PDF]

, 2013
Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. Several microorganism pathogens bind to the heparin-like glycosaminoglycans chains of proteoglycans at host-cell surface to promote their ...
Gesteira, Tarsis F., Juliano, Luiz, Tersariol, Ivarne L.S., Westrop, Gareth, Almeida, Paulo C, Souza, Gerson A., Judice, W.A.S., Sansevero, Thiago M., Sanderson, Sanya J, Coombs, Graham, Manfredi, Marcella A, Shida, Claudio S.   +11 more
core   +4 more sources

A trypsin-like serine protease is involved in pseudorabies virus invasion through the basement membrane barrier of porcine nasal respiratory mucosa

Veterinary Research, 2011
Several alphaherpesviruses breach the basement membrane during mucosal invasion. In the present study, the role of proteases in this process was examined.
Glorieux Sarah, Favoreel Herman W, Steukers Lennert, Vandekerckhove Annelies P, Nauwynck Hans J   +4 more
doaj   +1 more source