The under‐appreciated world of the serpin family of serine proteinase inhibitors [PDF]
EMBO Molecular Medicine, 2023 In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors that, in ...
Marie‐Christine Bouton +9 more
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Kazal-type serine proteinase inhibitors in the midgut of Phlebotomus papatasi [PDF]
Memorias do Instituto Oswaldo Cruz, 2013 Sandflies (Diptera: Psychodidae) are important disease vectors of parasites of the genus Leishmania, as well as bacteria and viruses. Following studies of the midgut transcriptome of Phlebotomus papatasi, the principal vector of Leishmania major, two non-
Leah Theresa Sigle +1 more
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Primary structure of potato Kunitz-type serine proteinase inhibitor [PDF]
Biological Chemistry, 2000 The serine proteinase inhibitor (PSPI-51) isolated from potato tubers (Solanum tuberosum L,) comprises two protein species with pi 5.2 and 6.3, denoted as PSPI-21-5.2 and PSPI-21-6.3, respectively.
Mentele, Reinhard +3 more
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Comparative Transcriptome Analysis Reveals Expression of Defense Pathways and Specific Protease Inhibitor Genes in Solanum lycopersicum in Response to Feeding by Tuta absoluta [PDF]
InsectsUnderstanding plant-insect interactions can help control the harm of herbivorous pests. According to transcriptome data, transcripts of Solanum lycopersicum responding to feeding by Tuta absoluta were screened for important endopeptidase inhibitors ...
Yan Zhou +4 more
doaj +2 more sources
Podocytes as novel sources of neutrophil serine proteases: expression and regulation by inflammatory molecular patterns [PDF]
Cellular and Molecular Life SciencesPodocytes are essential components of the glomerular filtration barrier and are increasingly recognized as immunologically active cells. Here, we demonstrate that human and rat podocytes express enzymatically active neutrophil serine proteases (NSPs ...
Aleksandra Wróblewska-Schmude +10 more
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A Clinical Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors
Current Issues in Molecular Biology, 2023 SARS-CoV-2 (severe acute respiratory syndrome) is highly infectious and causes severe acute respiratory distress syndrome (SARD), immune suppression, and multi-organ failure. For SARS-CoV-2, only supportive treatment options are available, such as oxygen
Desh Deepak Singh +3 more
doaj +1 more source
Pest protection conferred by a Beta vulgaris serine proteinase inhibitor gene. [PDF]
PLoS ONE, 2013 Proteinase inhibitors provide a means of engineering plant resistance to insect pests. A Beta vulgaris serine proteinase inhibitor gene (BvSTI) was fused to the constitutive CaMV35S promoter for over-expression in Nicotiana benthamiana plants to study ...
Ann C Smigocki +3 more
doaj +1 more source
Non‐peptide inhibitors of HCV serine proteinase [PDF]
FEBS Letters, 1998 We screened a chemical library of 2000 compounds for inhibitors of hepatitis C virus (HCV) serine proteinase using an in vitro screening method measuring the hydrolysis of the peptide substrate. Three compounds were found to be the most potent inhibitors (IC50<10−5 M).
Kakiuchi, Nobuko +6 more
openaire +2 more sources
The effect of melanin on the proteolytic potential of blood under alkali esophageal burn
Journal of Biological Research, 2020 Caustic esophageal burns are among serious medical problems of global significance. Due to a key role in biological processes proteolytic enzymes actively involved in the pathological mechanisms underpinning the development and progression of burn ...
Nataliia Chornenka +9 more
doaj +1 more source
A KLK4 proteinase substrate capture approach to antagonize PAR1
Scientific Reports, 2021 Proteinase-activated receptor-1 (PAR1), triggered by thrombin and other serine proteinases such as tissue kallikrein-4 (KLK4), is a key driver of inflammation, tumor invasiveness and tumor metastasis.
Eitan Rabinovitch +8 more
doaj +1 more source