Results 1 to 10 of about 38,382 (116)

The under‐appreciated world of the serpin family of serine proteinase inhibitors [PDF]

EMBO Molecular Medicine, 2023
In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors that, in ...
Marie‐Christine Bouton, Margarethe Geiger, William P Sheffield, James A Irving, David A Lomas, Sihong Song, Ritvik S Satyanarayanan, Liqiang Zhang, Grant McFadden, Alexandra R Lucas   +9 more
doaj   +2 more sources

Kazal-type serine proteinase inhibitors in the midgut of Phlebotomus papatasi [PDF]

Memorias do Instituto Oswaldo Cruz, 2013
Sandflies (Diptera: Psychodidae) are important disease vectors of parasites of the genus Leishmania, as well as bacteria and viruses. Following studies of the midgut transcriptome of Phlebotomus papatasi, the principal vector of Leishmania major, two non-
Leah Theresa Sigle, Marcelo Ramalho-Ortigao   +1 more
doaj   +2 more sources

Exploring the protease inhibitory potential of 2-bromo-2-nitro-1,3- propanediol (Bronopol): Initial findings [PDF]

Biochemistry and Biophysics Reports
The compound 2-bromo-2-nitropropane-1,3-diol also known as Bronopol (BP) is a widely used antimicrobial preservative which highly soluble in water. Although its antimicrobial mechanism has been well described, its potential to modulate protease activity ...
Chao Jiang, Gary Krzyzanowski, M. Rohan Fernando   +2 more
doaj   +2 more sources

Podocytes as novel sources of neutrophil serine proteases: expression and regulation by inflammatory molecular patterns [PDF]

Cellular and Molecular Life Sciences
Podocytes are essential components of the glomerular filtration barrier and are increasingly recognized as immunologically active cells. Here, we demonstrate that human and rat podocytes express enzymatically active neutrophil serine proteases (NSPs ...
Aleksandra Wróblewska-Schmude, Irena Audzeyenka, Wiktoria Mallek, Magdalena Wysocka, Adam Lesner, Magdalena Narajczyk, Felicja Gajdowska, Danuta Gutowska-Owsiak, Tomasz Kulesza, Dorota Rogacka, Agnieszka Piwkowska   +10 more
doaj   +2 more sources

A Clinical Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors

Current Issues in Molecular Biology, 2023
SARS-CoV-2 (severe acute respiratory syndrome) is highly infectious and causes severe acute respiratory distress syndrome (SARD), immune suppression, and multi-organ failure. For SARS-CoV-2, only supportive treatment options are available, such as oxygen
Desh Deepak Singh, Ihn Han, Eun-Ha Choi, Dharmendra Kumar Yadav   +3 more
doaj   +1 more source

Pest protection conferred by a Beta vulgaris serine proteinase inhibitor gene. [PDF]

PLoS ONE, 2013
Proteinase inhibitors provide a means of engineering plant resistance to insect pests. A Beta vulgaris serine proteinase inhibitor gene (BvSTI) was fused to the constitutive CaMV35S promoter for over-expression in Nicotiana benthamiana plants to study ...
Ann C Smigocki, Snezana Ivic-Haymes, Haiyan Li, Jelena Savić   +3 more
doaj   +1 more source

The effect of melanin on the proteolytic potential of blood under alkali esophageal burn

Journal of Biological Research, 2020
Caustic esophageal burns are among serious medical problems of global significance. Due to a key role in biological processes proteolytic enzymes actively involved in the pathological mechanisms underpinning the development and progression of burn ...
Nataliia Chornenka, Liudmyla Domylivska, Olga Kravchenko, Tetiana Koval, Liza Torgalo, Alexandra Kostiuk, Nataliia Raksha, Yana Raetska, Tetiana Beregova, Ludmila Ostapchenko   +9 more
doaj   +1 more source

A KLK4 proteinase substrate capture approach to antagonize PAR1

Scientific Reports, 2021
Proteinase-activated receptor-1 (PAR1), triggered by thrombin and other serine proteinases such as tissue kallikrein-4 (KLK4), is a key driver of inflammation, tumor invasiveness and tumor metastasis.
Eitan Rabinovitch, Koishiro Mihara, Amiram Sananes, Marianna Zaretsky, Michael Heyne, Julia Shifman, Amir Aharoni, Morley D. Hollenberg, Niv Papo   +8 more
doaj   +1 more source

Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation

Frontiers in Chemistry, 2021
During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications,
Timo Burster, Zhadyra Mustafa, Dinara Myrzakhmetova, Anuar Zhanapiya, Michal Zimecki   +4 more
doaj   +1 more source

Study on Serine Proteinase in the Muscle of Yesso Scallops (Mizuhopecten yessoensis）

Shipin gongye ke-ji, 2022
To investigate the effect of endogenous protease on the texture of Yesso scallop muscle during cold storage, the texture and protein change related indexes of Yesso scallop muscle was measured during 4 ℃ cold storage 7 d with a purpose to identify the ...
Qiuying REN, Yuan XIE, Ling WENG, Lingjing ZHANG, Qian ZHANG, Guangming LIU, Minjie CAO   +6 more
doaj   +1 more source