Results 41 to 50 of about 37,649 (300)

Squash inhibitor family of serine proteinases.

Acta Biochimica Polonica, 1996
Squash inhibitors of serine proteinases form an uniform family of small proteins. They are built of 27-33 amino-acid residues and cross-linked with three disulfide bridges. The reactive site peptide bond (P1-P1') is between residue 5 (Lys, Arg or Leu) and 6 (always Ile). High resolution X-ray structures are available for two squash inhibitors complexed
J, Otlewski, D, Krowarsch
openaire   +3 more sources

Purification and Characterization of a Novel Kazal-Type Trypsin Inhibitor from the Leech of Hirudinaria manillensis

Toxins, 2016
Kazal-type serine proteinase inhibitors are found in a large number of living organisms and play crucial roles in various biological and physiological processes.
Yanmei Lai, Bowen Li, Weihui Liu, Gan Wang, Canwei Du, Rose Ombati, Ren Lai, Chengbo Long, Hongyuan Li   +8 more
doaj   +1 more source

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

Toxins, 2021
A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments.
José María Gutiérrez, Laura-Oana Albulescu, Rachel H. Clare, Nicholas R. Casewell, Tarek Mohamed Abd El-Aziz, Teresa Escalante, Alexandra Rucavado   +6 more
doaj   +1 more source

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
O\u27Brien, Pamela, O'Brien, Pamela, O'Connor, Brendan, O\u27Connor, Brendan   +3 more
core   +1 more source

Isolation, cloning and structural characterisation of boophilin, a multifunctional Kunitz-type proteinase inhibitor from the cattle tick. [PDF]

PLoS ONE, 2008
Inhibitors of coagulation factors from blood-feeding animals display a wide variety of structural motifs and inhibition mechanisms. We have isolated a novel inhibitor from the cattle tick Boophilus microplus, one of the most widespread parasites of farm ...
Sandra Macedo-Ribeiro, Carla Almeida, Bárbara M Calisto, Thomas Friedrich, Reinhard Mentele, Jörg Stürzebecher, Pablo Fuentes-Prior, Pedro José Barbosa Pereira   +7 more
doaj   +1 more source

Inibidores de proteases de hospedeiros nativos e exóticos e sua ação em intestinos de lagartas de Thyrinteina leucoceraea Proteinase inhibitors of novel and native host plants and their action in midgut of Thyrinteina leucoceraea caterpillars

Revista Árvore, 2008
Os insetos podem causar perdas consideráveis aos seus hospedeiros, entretanto alguns deles habitam em plantas sem causar-lhes danos. Por exemplo, Thyrinteina leucoceraea, herbívoro da entomofauna brasileira, pode ser encontrado na goiabeira, hospedeiro ...
Jeanne Scardini Marinho, Maria Goreti Almeida Oliveira, Raul Narciso Carvalho Guedes, Angelo Pallini, Claudinei Lima Oliveira   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo. [PDF]

PLoS ONE, 2015
The α-defensins, human neutrophil peptides (HNPs) are the predominant antimicrobial peptides of neutrophil granules. They are synthesized in promyelocytes and myelocytes as proHNPs, but only processed in promyelocytes and stored as mature HNPs in ...
Andreas Glenthøj, Katrin Nickles, Jack Cowland, Niels Borregaard   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Cysteine proteinase inhibitors: purification and gene isolation [PDF]

, 1989
Genetic engineering has produced a transgenic insect- resistant plant which produces a serine protease inhibitor (Hilder et al., 1987). More insects can be targetted if a plant can be made to produce thiol protease inhibitors.
Fones, Angela Mei Ling
core