Results 61 to 70 of about 754,866 (196)

Prospeção de inibidores de serinoproteinases em folhas de leguminosas arbóreas da floresta Amazônica Prospecting serine proteinase inhibitors in leaves from leguminous trees of the Amazon forest

Acta Amazonica, 2011
Os inibidores de proteinases são proteínas extensivamente investigadas nos tecidos de estocagem, mas pouco prospectadas em outros tecidos vegetais. O objetivo deste estudo foi detectar a presença de inibidores de serinoproteinases em extratos foliares de
Larissa Ramos Chevreuil, José Francisco de Carvalho Gonçalves, Flávia Camila SCHIMPL, Cristiane Santos do Carmo Ribeiro de Souza, Luiz Augusto Gomes de Souza, Silvana Cristina Pando   +5 more
doaj   +1 more source

Targeting Inhibition of Fibroblast Activation Protein-α and Prolyl Oligopeptidase Activities on Cells Common to Metastatic Tumor Microenvironments

Neoplasia: An International Journal for Oncology Research, 2013
Fibroblast activation protein (FAP), a membrane prolyl-specific proteinase with both dipeptidase and endopeptidase activities, is overexpressed by reactive stromal fibroblasts during epithelial-derived cancer growth.
Victoria J. Christiansen, Kenneth W. Jackson, Kyung N. Lee, Tamyra D. Downs, Patrick A. McKee   +4 more
doaj   +1 more source

Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase. [PDF]

PLoS ONE, 2013
Neutrophil extracellular traps (NETs) consist of antimicrobial molecules embedded in a web of extracellular DNA. Formation of NETs is considered to be a defense mechanism utilized by neutrophils to ensnare and kill invading pathogens, and has been ...
Anthony J O'Donoghue, Ye Jin, Giselle M Knudsen, Natascha C Perera, Dieter E Jenne, John E Murphy, Charles S Craik, Terry W Hermiston   +7 more
doaj   +1 more source

Antiviral Cytokines Induce Hepatic Expression of the Granzyme B Inhibitors, Proteinase Inhibitor 9 and Serine Proteinase Inhibitor 6 [PDF]

The Journal of Immunology, 2004
Abstract Expression of the granzyme B inhibitors, human proteinase inhibitor 9 (PI-9), or the murine orthologue, serine proteinase inhibitor 6 (SPI-6), confers resistance to CTL or NK killing by perforin- and granzyme-dependent effector mechanisms.
Mahmoud B, Barrie, Heather W, Stout, Marwan S, Abougergi, Bonnie C, Miller, Dwain L, Thiele   +4 more
openaire   +2 more sources

Identification and characterisation of gut proteases in the fig tree skeletoniser moth, Choreutis nemorana Hübner (Lepidoptera: Choreutidae)

Plant Protection Science, 2013
The biochemical properties of proteases from the digestive system of the fig tree skeletonizer moth, Choreutis nemorana, were determined. Gut extracts of C.
Moloud GHOLAMZADEH CHITGAR, Mohammad GHADAMYARI, Mahbobe SHARIFI   +2 more
doaj   +1 more source

An alternative for proteinase K-heat-sensitive protease from fungus Onygena corvina for biotechnology: cloning, engineering, expression, characterization and special application for protein sequencing

Microbial Cell Factories, 2020
Background A neutral, heat-sensitive serine protease (NHSSP) originating from the feather-degrading fungus Onygena corvina (O. corvina) was described and defined as an alkaline serine protease of the subtilisin type S8 family, exhibiting an enzymatic ...
Piotr M. Skowron, Daria Krefft, Robert Brodzik, Paulina Kasperkiewicz, Marcin Drag, Klaus-Peter Koller   +5 more
doaj   +1 more source

Role of Proteases in Chronic Obstructive Pulmonary Disease

Frontiers in Pharmacology, 2017
Chronic obstructive pulmonary disease (COPD) is generally associated with progressive destruction of airways and lung parenchyma. Various factors play an important role in the development and progression of COPD, like imbalance of proteases ...
Kailash C. Pandey, Sajal De, Pradyumna K. Mishra   +2 more
doaj   +1 more source

Serine proteinase inhibitors from insect hemolymph.

Acta Biochimica Polonica, 1996
Insect hemolymph, like vertebrate serum, contains several different types of polypeptides that are able to inhibit the catalytic function of proteolytic enzymes, however studies on proteins possessing this capability have been limited to a relatively few species.
A, Polanowski, T, Wilusz
openaire   +3 more sources

Identification of Theaflavin-3,3’-Digallate as a Novel Zika Virus Protease Inhibitor

Frontiers in Pharmacology, 2020
Mounting evidence indicates that Zika virus (ZIKV) is closely related to neurological disorders such as microcephaly and Guillain-Barré syndrome. There are currently no effective vaccines and FDA-approved inhibitors against ZIKV infection. The flaviviral
Xiangling Cui, Rui Zhou, Chenchao Huang, Chenchao Huang, Rongyu Zhang, Rongyu Zhang, Jing Wang, Yongxin Zhang, Jiwei Ding, Jiwei Ding, Xiaoyu Li, Jinming Zhou, Jinming Zhou, Jinming Zhou, Shan Cen, Shan Cen, Shan Cen   +16 more
doaj   +1 more source

Serine proteinase inhibitors isolated from boar seminal plasma

, 2002
Serine proteinase inhibitors were found in boar seminal plasma. The work was concentrated on isolation and characterization of proteinase inhibitors and study of the existence of inhibitors in complexes with other proteins in seminal ...
Jelínková, Petra
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