Results 1 to 10 of about 32,538 (157)

Research progress on the effect of neutrophil elastase and its inhibitors in respiratory diseases [PDF]

Journal of International Medical Research
Neutrophil elastase is a serine protease secreted by neutrophils that plays a crucial role in the onset and progression of various respiratory diseases.
Cheng-Cheng Liang, Ji Zhao, Yan-Qiu Zhang, Jian Chen, Yong Wang   +4 more
exaly   +3 more sources

The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension [PDF]

Frontiers in Medicine, 2018
Pulmonary arterial hypertension (PAH) is a severe vasculopathy characterized by the presence of fibrotic lesions in the arterial wall and the loss of small distal pulmonary arteries.
Shalina Taylor, Shalina Taylor, Omar Dirir, Roham T. Zamanian, Roham T. Zamanian, Marlene Rabinovitch, Marlene Rabinovitch, A. A. Roger Thompson   +7 more
doaj   +7 more sources

Neutrophil elastase in bronchiectasis

Respiratory Research, 2017
The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF.
Andrea Gramegna, Francesco Amati, Leonardo Terranova, Giovanni Sotgiu, Paolo Tarsia, Daniela Miglietta, Maria Adelaide Calderazzo, Stefano Aliberti, Francesco Blasi   +8 more
doaj   +3 more sources

Triterpenoids as Neutrophil Elastase Inhibitors [PDF]

Natural Product Communications, 2015
Neutrophile elastase has the capacity to degrade elastin, a protein found in the connective tissue of the lungs. Unchecked elastase leads to pulmonary pathologies.
Dom Guillaume, Thi Ngoc Tram Huynh, Clément Denhez, Kim Phi Phung Nguyen, Azzaq Belaaouaj   +4 more
doaj   +3 more sources

Neutrophil elastase-activatable ratiometric photoacoustic nanoprobes for imaging atherosclerotic plaque vulnerability [PDF]

Nature Communications
Atherosclerosis is a leading cause of cardiovascular diseases worldwide. Neutrophil elastase, a key protease secreted by neutrophils, contributes significantly to atherosclerosis by degrading the extracellular matrix and destabilizing the fibrous cap of ...
Hui Cao, Xin Meng, Yuan Ma, Zhe Li, Xinyu Xu, Jiaqi Fu, Qingpeng Zhang, Hanlin Wei, Peng Liang, Dingyou Lu, Jinyu Li, Baoli Yin, Shuangyan Huan, Xiao-Bing Zhang, Guosheng Song   +14 more
doaj   +2 more sources

Neutrophil Elastase and Chronic Lung Disease [PDF]

Biomolecules, 2021
Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary disease, non-CF bronchiectasis, and bronchopulmonary dysplasia.
Judith A. Voynow, Meagan Shinbashi
doaj   +3 more sources

Neutrophil Elastase Defects in Congenital Neutropenia [PDF]

Frontiers in Immunology, 2021
Severe congenital neutropenia (SCN) is a rare hematological condition with heterogenous genetic background. Neutrophil elastase (NE) encoded by ELANE gene is mutated in over half of the SCN cases. The role of NE defects in myelocytes maturation arrest in
Zuzanna Rydzynska, Bartlomiej Pawlik, Bartlomiej Pawlik, Damian Krzyzanowski, Damian Krzyzanowski, Wojciech Mlynarski, Joanna Madzio   +6 more
doaj   +3 more sources

Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model [PDF]

Intensive Care Medicine Experimental
Background Neutrophil granulocytes are important parts of the defence against bacterial infections. Their action is a two-edged sword, the mediators killing the intruding bacteria are at the same time causing tissue damage.
Frida Wilske, Olof Eriksson, Rose-Marie Amini, Sergio Estrada, Helena Janols, Amina Khalil, Anders Larsson, Miklós Lipcsey, Sara Mangsbo, Jonathan Sigfridsson, Jan Sjölin, Paul Skorup, Anders Wall, Viola Wilson, Markus Castegren, Gunnar Antoni   +15 more
doaj   +2 more sources

Neutrophil Elastase-Mediated Lung Disease

COPD: Journal of Chronic Obstructive Pulmonary Disease, 2013
Elastases of both the neutrophil and macrophage have been implicated in lung disease initiation and progression. Although it is unlikely that these proteases evolved for the purpose of injuring lung tissue, the elastin-rich connective tissue framework of the lungs appears to be particularly susceptible to the action of elastolytic proteases.
Robert A Sandhaus, Gérard Turino
exaly   +3 more sources

The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Streptococcus pneumoniae, also known as pneumococcus, is a Gram-positive diplococcus and a major human pathogen. This bacterium is a leading cause of bacterial pneumonia, otitis media, meningitis, and septicemia, and is a major cause of morbidity and mortality worldwide. To date, studies onS.
Hisanori Domon, Hisanori Domon, Yutaka Terao, Yutaka Terao   +3 more
openaire   +3 more sources