Results 11 to 20 of about 152,807 (272)

Standardised Sonneratia apetala Buch.-Ham. fruit extract inhibits human neutrophil elastase and attenuates elastase-induced lung injury in mice [PDF]

Frontiers in Pharmacology, 2022
Chronic obstructive pulmonary disease (COPD) along with asthma is a major and increasing global health problem. Smoking contributes to about 80%–90% of total COPD cases in the world.
Sayantan Sengupta, Nipun Abhinav, Sabita Singh, Sabita Singh, Joytri Dutta, Joytri Dutta, Ulaganathan Mabalirajan, Ulaganathan Mabalirajan, Karthigeyan Kaliyamurthy, Pulok Kumar Mukherjee, Parasuraman Jaisankar, Parasuraman Jaisankar, Arun Bandyopadhyay, Arun Bandyopadhyay   +13 more
doaj   +2 more sources

Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses [PDF]

Respiratory Research, 2013
Background Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-
Koga Hikari, Miyahara Nobuaki, Fuchimoto Yasuko, Ikeda Genyo, Waseda Koichi, Ono Katsuichiro, Tanimoto Yasushi, Kataoka Mikio, Gelfand Erwin W, Tanimoto Mitsune, Kanehiro Arihiko   +10 more
doaj   +3 more sources

RNA Sequencing in COVID-19 patients identifies neutrophil activation biomarkers as a promising diagnostic platform for infections.

PLoS ONE, 2022
Infection with the SARS-CoV2 virus can vary from asymptomatic, or flu-like with moderate disease, up to critically severe. Severe disease, termed COVID-19, involves acute respiratory deterioration that is frequently fatal.
Richard Wargodsky, Philip Dela Cruz, John LaFleur, David Yamane, Justin Sungmin Kim, Ivy Benjenk, Eric Heinz, Obinna Ome Irondi, Katherine Farrar, Ian Toma, Tristan Jordan, Jennifer Goldman, Timothy A McCaffrey   +12 more
doaj   +2 more sources

Neutrophil elastase inhibitors [PDF]

Expert Opinion on Therapeutic Patents, 2011
Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health problem. There is currently an urgent and unmet need for the development of small molecule therapeutics capable of blocking and/or reversing the progression of the disorder.
Groutas, William C., Dou, Dengfeng, Alliston, Kevin R.   +2 more
openaire   +3 more sources

Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia

Scientific Reports, 2021
Bacterial and viral respiratory infections can initiate acute lung injury and acute respiratory distress syndrome. Neutrophils and their granule enzymes, including neutrophil elastase, are key mediators of the pathophysiology of acute respiratory failure.
Hisanori Domon, Tomoki Maekawa, Toshihito Isono, Kazuyuki Furuta, Chikara Kaito, Yutaka Terao   +5 more
doaj   +1 more source

Phagocyte extracellular traps in children with neutrophilic airway inflammation

ERJ Open Research, 2021
Childhood lung infection is often associated with prominent neutrophilic airway inflammation and excess production of proteases such as neutrophil elastase (NE). The mechanisms responsible for this inflammation are not well understood.
Paul T. King, Lovisa Dousha, Nadeene Clarke, Jennifer Schaefer, Rosemary Carzino, Roleen Sharma, Ken L. Wan, Aveena Anantharajah, Kim O'Sullivan, Zhong X. Lu, Stephen R. Holdsworth, Sarath Ranganathan, Philip G. Bardin, David S. Armstrong   +13 more
doaj   +1 more source

Flavonoids as inhibitors of human neutrophil elastase [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Elastase is a proteolytic enzyme belonging to the family of hydrolases produced by human neutrophils, monocytes, macrophages, and endothelial cells. Human neutrophil elastase is known to play multiple roles in the human body, but an increase in its activity may cause a variety of diseases.
Jakimiuk, Katarzyna, Gesek, Jakub, Atanasov, Atanas G., Tomczyk, Michał   +3 more
openaire   +4 more sources

Neutrophil elastase in the tumor microenvironment [PDF]

Steroids, 2018
Myeloid cell production within the bone marrow is accelerated in the setting of cancer, and the numbers of circulating and infiltrating neutrophils and granulocytic myeloid derived suppressor cells (MDSCs) correlate with tumor progression and patient survival.
Irina, Lerman, Stephen R, Hammes
openaire   +2 more sources

Value of circulating neutrophil elastase for detecting recurrence of differentiated thyroid cancer

Endocrine Connections, 2023
Objective: The inflammatory microenvironment has been implicated in differentiated thyroid cancer (DTC). Inflammatory stimuli induce the release of components of neutrophils into extracellular space, leading to formation of neutrophil extracellular trap (
Hyunjae Lee, Tae-Shin Kim, Ja-Yoon Gu, Mi Ran Yu, Seung-Eun Lee, Eun Sook Kim, Hyun Kyung Kim   +6 more
doaj   +1 more source

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase [PDF]

, 1986
The neutrophil has been implicated as an important mediator of vascular injury, especially after endotoxemia. This study examines neutrophil-mediated injury to human microvascular endothelial cells in vitro. We found that neutrophils stimulated by formyl-
M G Tonnesen, Guthrie, L A, P M Henson, G S Worthen, C Haslett, Tonnesen, M G, Smedly, LA, Worthen, G S, Sandhaus, R A, R B Johnston, Henson, P M, L A Guthrie, L A Smedly, Johnstone Jr., R.B, Haslett, Christopher, R A Sandhaus   +15 more
core   +1 more source