Results 21 to 30 of about 152,807 (272)

Paternal mosaicism proves the pathogenic nature of mutations in neutrophil elastase in severe congenital neutropenia [PDF]

, 2002
Heterozygous mutations in neutrophil elastase have been detected in many sporadic cases of congenital neutropenia. However, a convincing pathogenetic mechanism has not been established, and it is unclear whether the effects of the mutant enzyme occur ...
Ancliff, PJ, Gale, RE, David C. Linch, Rosemary E. Gale, Ri Liesner, Phil J. Ancliff, Ian M. Hann, Strobel, S, Liesner, R, Hann, IM, Watts, MJ, Michael J. Watts, Stephan Strobel, Linch, DC   +13 more
core   +1 more source

Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]

, 2011
Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Hennig, Theres, Christina Mogensen, Gloe, Torsten, Kirsch, Julian, Julian Kirsch, Torsten Gloe, Ulrich Pohl, Pohl, Ulrich, Theres Hennig, Mogensen, Christina   +9 more
core   +1 more source

Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis [PDF]

, 1994
Die Diskussion am Ende des Artikels wurde gelöscht (§137l UrhG).Background The proteolytic enzyme elastase released by granulocytes (polymorphonuclear leukocytes [PMN]) in high concentrations during sepsis causes degradation of essential plasma proteins,
Schildberg, Friedrich-Wilhelm, Wolfgang Ertel, Jochum, Marianne, Thiele, Volker, Jarrar, Doreid, Kenney, John, Faist, Eugen, Ertel, Wolfgang   +7 more
core   +1 more source

In Vitro Inhibition of Neutrophil Elastase Activity by Inhaled Anti-Pseudomonas Antibiotics Used in Cystic Fibrosis Patients

Mediators of Inflammation, 2010
Background. Inhaled antibiotics are commonly used in the treatment of cystic fibrosis lung disease. A previous study suggested neutrophil elastase activation by colistin in vitro.
Andreas Hector, Matthias Kappler, Matthias Griese   +2 more
doaj   +1 more source

Differential Inhibition of Human Neutrophil Elastase and Bacterial Elastase by endogenous Protease Inhibitors

Journal of Clinical and Biomedical Sciences, 2018
Human Neutrophil Elastase (HNE) is released from neutrophils when foreign substances are encoun-tered. Elastase is also released by invasive pathogenic microorganisms and is an important virulence factor.
Deena Mendez, Prasad SR, Kutty AVM
doaj   +1 more source

Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase. [PDF]

PLoS ONE, 2013
Exposure of human skin to solar ultraviolet (UV) irradiation induces matrix metalloproteinase-1 (MMP-1) activity, which degrades type I collagen fibrils. Type I collagen is the most abundant protein in skin and constitutes the majority of skin connective
Yong Li, Wei Xia, Ying Liu, Henriette A Remmer, John Voorhees, Gary J Fisher   +5 more
doaj   +1 more source

Clinical results of application of lymphotropic antibioticotherapy in patients with an acute pancreatitis

Український журнал клінічної хірургії, 2023
Objective.. To compare the clinical results of application of lymphotropic therapy and standard procedure of parenteral introduction of preparations. Materials and methods.
I. D. Duzhyi, O. L. Sytnik, G. I. Piatikop   +2 more
doaj   +1 more source

Inhibition of neutrophil activity improves cardiac function after cardiopulmonary bypass [PDF]

, 2007
Background The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery.
Windolf Joachim, Scholz Martin, Francischetti, Ieda, Kranert Tilmann, Bitu-Moreno José, Moritz Anton, Francischetti Ieda, Kranert, Tilmann, Windolf, Joachim, Lögters, Tim Tobias, Bitu-Moreno, José, Margraf, Stefan, Abdel-Rahman Ulf, Abdel-Rahman, Ulf, Aybek, Tayfun, Grünwald, Frank (Prof. Dr.), Lögters Tim, Margraf Stefan, Grünwald Frank, Scholz, Martin, Moritz, Anton, Aybek Tayfun   +21 more
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Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1‐antitrypsin in lung cancer

Molecular Oncology, 2012
Lung carcinogenesis is a complex process in an unregulated inflammatory environment. Curcumin has been extensively investigated as a multi‐target anti‐tumor and anti‐inflammation compound.
Yan Xu, Jingjie Zhang, Jing Han, Xueyang Pan, Yajun Cao, Hao Guo, Yan Pan, Yu An, Xuejun Li   +8 more
doaj   +1 more source

Diversity Oriented Clicking: Synthesis of beta-Substituted Alkenyl Sulfonyl Fluorides as Covalent Human Neutrophil Elastase Inhibitors [PDF]

, 2022
Diversity Oriented Clicking (DOC) is a discovery method geared towards the rapid synthesis of functional libraries. It combines the best attributes of both classical and modern click chemistries. DOC strategies center upon the chemical diversification of
Yunfei, Cheng, John R. , Cappiello, Stefano, Forli, Seiya, Kitamura, Joshua A., Homer, K. Barry, Sharpless, Jordan L., Woehl, Gencheng , Li, Giulia, Bianco, Dennis W., Wolan, Christopher J. , Smedley, Marie-Claire, Giel, John E., Moses   +12 more
core   +2 more sources