Results 51 to 60 of about 37,649 (300)

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Wosikowski, K., Probst, C., Sander, C. A., Degitz, K., Schuh, T., Flaig, M. J., Braungart, E., Douwes, K., Magdolen, V.   +9 more
core   +1 more source

Biochemical characterization of Anopheles gambiae SRPN6, a malaria parasite invasion marker in mosquitoes. [PDF]

PLoS ONE, 2012
Serine proteinase inhibitors of the serpin family are well known as negative regulators of hemostasis, thrombolysis and innate immune responses. Additionally, non-inhibitory serpins serve functions as chaperones, hormone transporters, or anti-angiogenic ...
Chunju An, Yasuaki Hiromasa, Xin Zhang, Scott Lovell, Michal Zolkiewski, John M Tomich, Kristin Michel   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Enzymatic characterization of purified NS3 serine proteinase of hepatitis C virus expressed in Escherichia coli [PDF]

, 1996
Non-structural protein 3 (NS3) of the hepatitis C virus (HCV) has been shown to be a serine proteinase which cleaves the HCV polyprotein thus activating its replicative machinery.
Tomoko Koide, Yuasa, Satoshi, Moria, Akiko, Kazunori Yamada, Junko Kimura, Yamadaa, Ei, Kimura, Junko, Ei Yamadaa, Koide, Tomoko, Miyamura, Tatsuo, Tatsuo Miyamura, Yamada, Kazunori, Akiko Moria, Satoshi Yuasa   +13 more
core   +1 more source

Subproteome of Lachesis muta rhombeata venom and preliminary studies on LmrSP-4, a novel snake venom serine proteinase

Journal of Venomous Animals and Toxins including Tropical Diseases, 2019
Background: Lachesis muta rhombeata is one of the venomous snakes of medical importance in Brazil whose envenoming is characterized by local and systemic effects which may produce even shock and death.
Gisele A Wiezel, Karla CF Bordon, Ronivaldo R Silva, Mário SR Gomes, Hamilton Cabral, Veridiana M Rodrigues, Beatrix Ueberheide, Eliane C Arantes   +7 more
doaj   +1 more source

The Role of EREG, PTPN1, and SERPINB7 Genes in the Pathogenesis of Psoriasis: May SERPINB7 Be Protective and a Marker of Severity for Psoriasis?

Dermatology Practical & Conceptual, 2023
Introduction: Psoriasis is a chronic inflammatory dermatological disease with complex pathogenesis in which many immune system cells, including keratinocytes, play a role. Many genes regulate the proliferation of keratinocytes and other immune cells that
Havva Hilal Ayvaz, Kuyaş Hekimler Öztürk, Mehmet Ali Seyirci, Emrah Atay, Selma Korkmaz, İjlal Erturan, Mehmet Yıldırım   +6 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

Cell Reports, 2019
Summary: Neutrophil granule serine proteases contribute to immune responses through cleavage of microbial toxins and structural proteins. They induce tissue damage and modulate inflammation if levels exceed their inhibitors.
Sabrina Sofia Burgener, Nathan Georges François Leborgne, Scott J. Snipas, Guy S. Salvesen, Phillip Ian Bird, Charaf Benarafa   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Serine proteinase inhibitors isolated from boar seminal plasma [PDF]

, 2002
Serine proteinase inhibitors were found in boar seminal plasma. The work was concentrated on isolation and characterization of proteinase inhibitors and study of the existence of inhibitors in complexes with other proteins in seminal ...
Jelínková, Petra
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