Results 51 to 60 of about 754,866 (196)

The Role of EREG, PTPN1, and SERPINB7 Genes in the Pathogenesis of Psoriasis: May SERPINB7 Be Protective and a Marker of Severity for Psoriasis?

Dermatology Practical & Conceptual, 2023
Introduction: Psoriasis is a chronic inflammatory dermatological disease with complex pathogenesis in which many immune system cells, including keratinocytes, play a role. Many genes regulate the proliferation of keratinocytes and other immune cells that
Havva Hilal Ayvaz, Kuyaş Hekimler Öztürk, Mehmet Ali Seyirci, Emrah Atay, Selma Korkmaz, İjlal Erturan, Mehmet Yıldırım   +6 more
doaj   +1 more source

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

Cell Reports, 2019
Summary: Neutrophil granule serine proteases contribute to immune responses through cleavage of microbial toxins and structural proteins. They induce tissue damage and modulate inflammation if levels exceed their inhibitors.
Sabrina Sofia Burgener, Nathan Georges François Leborgne, Scott J. Snipas, Guy S. Salvesen, Phillip Ian Bird, Charaf Benarafa   +5 more
doaj   +1 more source

A novel in vitro cell model of the proteinase/antiproteinase balance observed in alpha-1 antitrypsin deficiency

Frontiers in Pharmacology
Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition resulting from mutations in the alpha-1 antitrypsin (AAT) protein, a major systemic antiproteinase, resulting in reduced/no release of AAT, disrupting the proteinase/antiproteinase ...
Celine H. Chen, Helena Crisford, Aaron Scott, Aaron Scott, Elizabeth Sapey, Elizabeth Sapey, Elizabeth Sapey, Robert A. Stockley, Robert A. Stockley   +8 more
doaj   +1 more source

Investigação sobre a adaptação do inseto praga de cereais Tenebrio molitor a inibidores de proteinases digestivas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2010Nas larvas de Tenebrio molitor (verme do trigo) são encontrados variados tipos de proteinases ...
Alexandre, Daniel
core  

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Wosikowski, K., Probst, C., Sander, C. A., Degitz, K., Schuh, T., Flaig, M. J., Braungart, E., Douwes, K., Magdolen, V., C.A. Sander, C. Probst, K. Wosikowski, K. Degitz, T. Schuh, R. Besch, E. Braungart, V. Magdolen, M.J. Flaig, K. Douwes   +19 more
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Recombinant Trichinella pseudospiralis Serine Protease Inhibitors Alter Macrophage Polarization In Vitro

Frontiers in Microbiology, 2017
During parasite infection, serine protease inhibitors secreted by parasites play important roles in suppressing host defenses. However, the mechanism of immune regulation is unclear.
Ning Xu, Xiaolei Liu, Bin Tang, Libo Wang, Hai N. Shi, Pascal Boireau, Pascal Boireau, Mingyuan Liu, Mingyuan Liu, Xue Bai   +9 more
doaj   +1 more source

ANISERP: a new serpin from the parasite Anisakis simplex

Parasites & Vectors, 2015
Background Serine proteinase inhibitors (serpins) finely regulate serine proteinase activity via a suicide substrate-like inhibitory mechanism. In parasitic nematodes, some serpins interact with host physiological processes; however, little is known ...
Elizabeth Valdivieso, Maria J. Perteguer, Carolina Hurtado, Pamela Campioli, Esperanza Rodríguez, Ana Saborido, Victoria Martínez-Sernández, Paulino Gómez-Puertas, Florencio M. Ubeira, Teresa Gárate   +9 more
doaj   +1 more source

Inhibitor Complexes of the Pseudomonas Serine-Carboxyl Proteinase

Biochemistry, 2001
Crystal structures of the serine-carboxyl proteinase from Pseudomonas sp. 101 (PSCP), complexed with a number of inhibitors, have been solved and refined at high- to atomic-level resolution. All of these inhibitors (tyrostatin, pseudo-tyrostatin, AcIPF, AcIAF, and chymostatin, as well as previously studied iodotyrostatin and pseudo-iodotyrostatin) make
A, Wlodawer, M, Li, A, Gustchina, Z, Dauter, K, Uchida, H, Oyama, N E, Goldfarb, B M, Dunn, K, Oda   +8 more
openaire   +2 more sources

Enzymatic characterization of purified NS3 serine proteinase of hepatitis C virus expressed in Escherichia coli [PDF]

, 1996
Non-structural protein 3 (NS3) of the hepatitis C virus (HCV) has been shown to be a serine proteinase which cleaves the HCV polyprotein thus activating its replicative machinery.
Tomoko Koide, Yuasa, Satoshi, Moria, Akiko, Kazunori Yamada, Junko Kimura, Yamadaa, Ei, Kimura, Junko, Ei Yamadaa, Koide, Tomoko, Miyamura, Tatsuo, Tatsuo Miyamura, Yamada, Kazunori, Akiko Moria, Satoshi Yuasa   +13 more
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Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide–PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer

Scientific Reports, 2018
Amphibian venom-derived peptides have high potential in the field of anticancer drug discovery. We have isolated a novel Bowman-Birk proteinase inhibitor (BBI)-type peptide from the skin secretion of Pelophylax esculentus (PE) named PE-BBI, and evaluated
Peng Lyu, Lilin Ge, Rui Ma, Ran Wei, Cian M. McCrudden, Tianbao Chen, Chris Shaw, Hang Fai Kwok   +7 more
doaj   +1 more source