Results 31 to 40 of about 37,649 (300)
The effects of a plant proteinase inhibitor from Enterolobium contortisiliquum on human tumor cell lines [PDF]
, 2011 Supplementary to the efficient inhibition of trypsin, chymotrypsin, plasma kallikrein, and plasmin already described by the EcTI inhibitor from Enterolobium contortisiliquum, it also blocks human neutrophil elastase (K(iapp)=4.3 nM) and prevents phorbol ...
Sampaio, Misako U. [UNIFESP] +21 more
core +1 more source
Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]
, 2011 Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines +5 more
core +2 more sources
Investigating Polypharmacology Through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3 [PDF]
, 2023 Using a combination of state-of-the-art free energy computational approaches together with in vitro IC50 assays, we evaluated the polypharmacological potential of a scaffold currently in clinical trials for inhibition of human neutrophil elastase (HNE ...
Fahimeh, Khorsand +8 more
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Mediators of Inflammation, 2013 Serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors (PARs). However, little is known about the influence of serine proteinases and PARs on TNF secretion from highly purified T cells.
Haiwei Yang +4 more
doaj +1 more source
Virology Journal, 2005 Through the use of transient expression assays and directed genetics, the vaccinia virus (VV) I7L gene product has been implicated as the major maturational proteinase required for viral core protein cleavage to occur during virion assembly.
Hruby Dennis E, Byrd Chelsea M
doaj +1 more source
Dietary regulation of serine proteinases that are resistant to serine proteinase inhibitors
Journal of Insect Physiology, 1997 Ingestion of Kunitz soybean trypsin inhibitor (STI) by larval Helicoverpa zea, Agrotis ipsilon, and Trichoplusia ni extended the retention time of food in the digestive tract and increased the level of activity of proteolytic enzymes that were not susceptible to inhibition by STI.
openaire +2 more sources
Serine proteinases and their inhibitors in Phycomyces blakesleeanus.
Journal of Biological Chemistry, 1979 Three serine proteinases of Phycomyces blakesleeanus were isolated and characterized. The molecular weights were determined to be 18,000, 22,000, and 60,000. The proteinases were solubilized by detergent or salt treatment. Two soluble proteins that specifically inhibit these proteinases were also isolated and characterized. Both these proteins formed 1:
E P, Fischer, K S, Thomson
openaire +2 more sources
The use of phenyl-Sepharose for the affinity purification of proteinases [PDF]
, 1993 Phenyl-Sepharose is most often used as an adsorbent for hydrophobic interaction chromatography (HIC). We report on its effective use for the affinity purification of some extracellular thermostable proteinases from bacterial sources.
Prescott, Mark +3 more
core +1 more source
TMPRSS2 as a Key Player in Viral Pathogenesis: Influenza and Coronaviruses
BiomoleculesTMPRSS2, a human transmembrane protease enzyme, plays a crucial role in the spread of certain viruses, including influenza and coronaviruses. This enzyme promotes viral infection by cleaving viral glycoproteins, which helps viruses like SARS-CoV-2 and ...
Gilmara Barros de Lima +5 more
doaj +1 more source
Proteinase inhibitors in Brazilian leguminosae
Memorias do Instituto Oswaldo Cruz, 1991 Serine proteinase inhitors, in the seeds of several Leguminosae from the Pantanal region (West Brazil), were studied using bovine trypsin, a digestive enzyme, Factor XIIa and human plasma Kallikrein, two blood clotting factors.
C. A. M. Sampaio +3 more
doaj +1 more source