Results 81 to 90 of about 2,558 (137)

A mitochondrial unfolded protein response inhibitor suppresses prostate cancer growth in mice via HSP60

The Journal of Clinical Investigation, 2022
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar, Ajay K. Chaudhary, Jordan Woytash, Joseph R. Inigo, Abhiram A. Gokhale, Wiam Bshara, Kristopher Attwood, Jianmin Wang, Joseph A. Spernyak, Eva Rath, Neelu Yadav, Dirk Haller, David W. Goodrich, Dean G. Tang, Dhyan Chandra   +14 more
doaj   +1 more source

Engineering Bacillus pumilus alkaline serine protease to increase its low-temperature proteolytic activity by directed evolution

BMC Biotechnology, 2018
Background Mesophilic alkaline serine proteases from various bacteria have been commercially applied in a range of industries owing to their high catalytic efficiency and wide substrate specificity.
Hong-Yan Zhao, Hong Feng
doaj   +1 more source

Identification of Potent Modulators of Human Caseinolytic Protease P for the Treatment of Hepatocellular Carcinoma: Molecular Docking, Density Functional Theory Calculation, Molecular Dynamic Simulation Studies, and In vitro Validation

Biomedical and Biotechnology Research Journal
Background: Human caseinolytic protease P (HsClpP) is a mitochondrial protease playing a vital role in mitochondrial protein quality control and represents a promising therapeutic target for hepatocellular carcinoma (HCC).
Chun Wang, Minghui Sha, Weilin Gong, Zili Sun, Dan Xu, Di Wu, Hailei Ji   +6 more
doaj   +1 more source

Caseinolytic protease P (CLPP) activated by ONC201 inhibits proliferation and promotes apoptosis in human epithelial ovarian cancer cells by inducing mitochondrial dysfunction. [PDF]

Ann Transl Med, 2021
Kou X, Ding H, Li L, Chao H.
europepmc   +1 more source

Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Pharmaceuticals
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue.
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati   +18 more
doaj   +1 more source

Development and evaluation of mitochondria-targeted caseinolytic protease (ClpP) agonist chemical probes in in vitro breast cancer models. [PDF]

Med Chem Res
Hao X, Purohit G, Jayasinghe YP, Ronning DR, Khalimonchuk O, Trippier PC.   +5 more
europepmc   +1 more source

Knockdown of Adenosine 5'-Triphosphate-Dependent Caseinolytic Protease Proteolytic Subunit 6 Enhances Aluminum Tolerance in Peanut Plants (Arachis hypogea L.). [PDF]

Int J Mol Sci
Shi Y, Zhang D, Liang R, Xiao D, Wang A, He L, Zhan J.   +6 more
europepmc   +1 more source

Silencing an ATP-Dependent Caseinolytic Protease Proteolytic Subunit Gene Enhances the Resistance of Rice to Nilaparvata lugens. [PDF]

Int J Mol Sci
Chen S, Ye M, Kuai P, Chen L, Lou Y.
europepmc   +1 more source

Mechanistic studies of mycobacterial caseinolytic proteases (Clp)

, 2014
openaire   +2 more sources

Keratinolytic proteases secreted by Bacillus subtilis obtained from feather-based submerged culture. [PDF]

Braz J Microbiol
de Menezes CLA, Barreto RA, Ribeiro ER, Pereira ÉJ, Thomaz LL, Boscolo M, da Silva R, Gomes E, da Silva RR.   +8 more
europepmc   +1 more source