Results 91 to 100 of about 4,619 (182)

Transferring an optimized TAP-toolbox for the isolation of protein complexes to a portfolio of rice tissues [PDF]

, 2016
Proteins are the cell's functional entities. Rather than operating independently, they interact with other proteins. Capturing in vivo protein complexes is therefore crucial to gain understanding of the function of a protein in a cellular context ...
Cannoot, Bernard, De Jaeger, Geert, De Winne, Nancy, Dedecker, Maarten, Dumoulin, Lies, Eeckhout, Dominique, Gevaert, Kris, Persiau, Geert, Van De Slijke, Eveline, Van Leene, Jelle, Vandenabeele, Steven, Vercruysse, Leen, Wojsznis, Nathalie   +12 more
core   +1 more source

Frontiers in the Management of Orthopaedic Periprosthetic Joint Infection

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
ABSTRACT Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty (TJA), one of the most frequently performed surgical procedures worldwide. Management of acute PJI commonly involves debridement, antibiotics, and implant retention (DAIR), though failure rates remain high due to antibiotic‐tolerant biofilms. Chronic
Michael F. Shannon, Victoria R. Wong, Samuelson E. Osifo, Timothy Edwards, Himanshu Rao, Jewelia Rempuszewski, Andrew J. Frear, Shaan Sadhwani, Neel B. Shah, Kenneth L. Urish   +9 more
wiley   +1 more source

Effects of GLP-1 receptor agonist on changes in the gut bacterium and the underlying mechanisms

Scientific Reports, 2021
There is a close relationship between the gut microbiota and metabolic disorders. In this study, acute administration of the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide to mice increased the cecal levels of caseinolytic protease B, a ...
Shunsuke Kato, Takehiro Sato, Hiroki Fujita, Masahiro Kawatani, Yuichiro Yamada   +4 more
doaj   +1 more source

Functional Interaction Between Toc75 POTRA1 Domain and Tic22‐III in the Intermembrane Space During Chloroplast Protein Import

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT Chaperones are essential for facilitating the import of nuclear‐encoded precursor proteins into chloroplasts. In the intermembrane space (IMS) of the chloroplasts, this process is mediated by the transport‐associated domains (POTRA) of the translocon at the outer envelope membrane (Toc75) and translocon at the inner envelope membrane (Tic22 ...
Rajneesh Singhal, Danny J. Schnell
wiley   +1 more source

Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad [PDF]

Proceedings of the National Academy of Sciences, 2013
Caseinolytic proteases (ClpPs) are large oligomeric protein complexes that contribute to cell homeostasis as well as virulence regulation in bacteria. Although most organisms possess a single ClpP protein, some organisms encode two or more ClpP isoforms. Here, we elucidated the crystal structures of ClpP1 and ClpP2 from pathogenic
E. Zeiler, A. List, F. Alte, M. Gersch, R. Wachtel, M. Poreba, M. Drag, M. Groll, S. A. Sieber   +8 more
openaire   +2 more sources

Lipid Nanoparticles Delivering ClpP‐mRNA Suppress Pyroptosis and Senescence in Intervertebral Disc Degeneration via mTOR/BNIP3‐Activated Mitophagy

Rare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Intervertebral disc degeneration (IDD) is a predominant cause of low back pain, significantly impacting quality of life. Mitochondrial fitness is essential in the progression of IDD, as it regulates cellular senescence and pyroptosis. This study investigates the role of mitochondrial caseinolytic protease P (ClpP) in alleviating senescence and
Kun Wang, Zhiqiang Wang, Tong Zhang, Shicheng Qiu, Guang Yang, Yanzheng Gao, Xiaofeng Lian, Xin Peng   +7 more
wiley   +1 more source

An open axial channel of the AAA ClpXP protease enhances degradation of specific classes of protein substrates

Protein Science, Volume 35, Issue 1, January 2026.
Abstract ClpXP and other AAA proteases maintain proteostasis and regulate cellular functions by degrading misfolded, incomplete, or regulatory proteins. ClpX recognizes substrates via unstructured degron sequences, typically located at the N‐ or C‐terminus. Although five classes of degrons are known, only recognition of the ssrA tag, a C‐motif‐1 degron,
Yifei Lyu, Isabella Bolstad, Joseph H. Davis, Robert T. Sauer, Alireza Ghanbarpour   +4 more
wiley   +1 more source

Ekstrakcija i pročišćavanje glukoamilaze i proteaze, proizvedenih jednostupanjskom fermentacijom s pomoću Aspergillus awamori [PDF]

, 2011
Simultaneous extraction and purification of glucoamylase and protease produced concomitantly by Aspergillus awamori Nakazawa MTCC 6652 in a single fermentor using solid-state fermentation (SSF) has been studied.
Rintu Banerjee, Sangeeta Negi, Suneel Gupta   +2 more
core   +1 more source

Polychromophilus spp. (Haemosporida: Plasmodiidae): First Molecular Detection in Bat Flies From Brazilian Bats

Integrative Zoology, Volume 21, Issue 1, Page 137-150, January 2026.
This study identifies Polychromophilus sp. in blood‐feeding flies (Basilia speiseri and Basilia lindolphoi) from Myotis nigricans bats in Brazil, marking the first molecular detection of the parasite in an insect vector in this country. Two haplotypes were identified, both within the Polychromophilus murinus group.
Bruno S. Mathias, Vinicio R. De Lima, Gustavo Graciolli, Nubia R. M. F. Rocha, Jaciara O. J. Costa, Herbert S. Soares, Arlei Marcili, Karin Kirchgatter   +7 more
wiley   +1 more source

Phylogenomic analyses of malaria parasites and evolution of their exported proteins [PDF]

, 2011
Background Plasmodium falciparum is the most malignant agent of human malaria. It belongs to the taxon Laverania, which includes other ape-infecting Plasmodium species. The origin of the Laverania is still debated.
Christian Pick, Ingo Ebersberger, Tobias Spielmann, Iris Bruchhaus, Thorsten Burmester   +4 more
core   +1 more source