Results 91 to 100 of about 147,909 (161)

Synthesis of a Carbon‐Linked Acyldepsipeptide Derivative

European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.
The synthesis of a methylene‐linked acyldepsipeptide (ADEP) is reported. Success relied upon an improve method to generate a versatile vinyl glycine methyl ester synthon and a rationally optimized Grubb’s metathesis. NMR and in silico studies revealed an unusual trans–trans proline orientation for this new unnatural ADEP analog, advancing the ...
Katelyn G. Stevens-Davis, Xiaozheng Dou, Bo Hu, Yangxiong Li, Jiayuan Miao, Yu-Shan Lin, Adam S. Duerfeldt   +6 more
wiley   +1 more source

Enterobacterial caseinolytic protease B (ClpB) and ClpB antibodies in adolescents with anorexia nervosa

Journal of Psychiatric Research
Caseinolytic protease B (ClpB) produced by the gut enterobacteria displays anorexigenic effects possibly due to its molecular mimicry with α-melanocyte-stimulating hormone (α-MSH), an anorexigenic neuropeptide. ClpB is known to induce α-MSH cross-reactive antibodies previously associated with eating disorders.
Benjamin Thomas, Nadia Andrea Andreani, Emilie Lahaye, John F. Baines, Beate Herpertz-Dahlmann, Jochen Seitz, Sergueï O. Fetissov   +6 more
openaire   +2 more sources

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, Volume 13, Issue 22, 17 April 2026.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

From Beer to Cheese: Characterization of Caseinolytic and Milk-Clotting Activities of Proteases Derived from Brewer’s Spent Grain (BSG)

Foods
This study explores the extraction and characterization of proteolytic enzymes from brewer’s spent grain (BSG) and their potential as sustainable coagulants in the dairy industry.
Maximiliano M. Villegas, Johana N. Silva, Florencia R. Tito, Claudia V. Tonón, Fernando F. Muñoz, Alfonso Pepe, María G. Guevara   +6 more
doaj   +1 more source

The Caseinolytic Protease P System in Clostridium difficile [PDF]

, 2019
Clostridium difficile is a Gram-positive, spore-forming, toxin producing pathogen that has rapidly gained resistance to several broad-spectrum antibiotics. C. difficile infection (CDI) is a leading cause of hospital-acquired illness and presents a unique
Lavey, Nathan
core  

Bioinspired Bromination Enables Extensible, Strain‐Stiffening Resilin Peptide Scaffolds with Tunable Degradation

Advanced Functional Materials, Volume 36, Issue 19, 5 March 2026.
Bioinspired bromination of a resilin‐derived peptide enables the fabrication of electrospun nanofibrous scaffolds that uniquely combine strain‐stiffening elasticity, proteolytic stability, and antioxidant functionality. These brominated peptide–gelatin hybrids mimic the extensibility of natural elastomers, demonstrating tunable mechanical resilience ...
Elisa Marelli, Lorenzo Sori, Chiara Russo, Claudia Pigliacelli, Lorenza Draghi, Monica Soncini, Pierangelo Metrangolo   +6 more
wiley   +1 more source

Extraction, purification, and activity of protease from the leaves of Moringa oleifera [version 1; referees: 2 approved, 1 approved with reservations]

F1000Research, 2018
Background: Proteases cleave proteins, thereby providing essential amino acids for protein synthesis, and degrade misfolded and damaged proteins to maintain homeostasis.
Swarnali Banik, Shrutidhara Biswas, Srabani Karmakar   +2 more
doaj   +1 more source

Synergistic interaction of a protease and protease inhibitors from Russell's viper (Vipera russelli) venom [PDF]

, 1990
Synergistic interaction of a protease and protease inhibitors from Russell's viper (Vipera russelli) venom. Toxicon28, 65–74, 1990.—An acidic proteolytic enzyme, RVVX, was purified from Vipera russelli venom by successive chromatography on CM-Sephadex C ...
Veerabasappa Gowda, T., Jayanthi, G. P.
core  

Engineering Bacillus pumilus alkaline serine protease to increase its low-temperature proteolytic activity by directed evolution

BMC Biotechnology, 2018
Background Mesophilic alkaline serine proteases from various bacteria have been commercially applied in a range of industries owing to their high catalytic efficiency and wide substrate specificity.
Hong-Yan Zhao, Hong Feng
doaj   +1 more source

Discovery of a Novel Series of Homo sapiens Caseinolytic Protease P Agonists for Colorectal Adenocarcinoma Treatment via ATF3-Dependent Integrated Stress Response

Homo sapiens caseinolytic protease P (HsClpP) activation is a promising strategy for colon cancer treatment. In this study, CCG1423 was identified as a selective activator of HsClpP. After optimization, NCA029 emerged as the most potent compound, with an
Zhiqiang Qiu (4603993), Youfu Luo (1819777), Jiangnan Zhang (1793173), Zhengyi Dai (5470733), Song Liu (9858), Tao Yang (184280), Xinrong Xiang (17935755), Jiasheng Huang (6641330), Baozhu Luo (12624724), Jing Sui (159664)   +9 more
core   +2 more sources