Mljekarstvo, 2022 Proteases of Lactobacillus and Lactococcus strains catalyze casein degradation in fermented dairy products, which can result in the production of bioactive peptides.
Jasna Novak +9 more
doaj +6 more sources
A Photocrosslinking Probe to Capture the Substrates of Caseinolytic Protease P
Angewandte Chemie - International EditionAbstractProtein homeostasis in bacteria is regulated by proteases such as the tetradecameric caseinolytic protease P (ClpP). Although substrates of ClpP have been successfully deciphered in genetically engineered cells, methods which directly trap processed proteins within native cells remain elusive.
Thomas F. Gronauer +3 more
exaly +4 more sources
Targeting human caseinolytic protease P (ClpP) as a novel therapeutic strategy in ovarian cancer
MedComm – Oncology, 2022 Ovarian cancer (OC) is currently one of the most life‐threatening types of gynecological malignancy with limited treatment options and poor clinical outcomes.
Youfu Luo
exaly +2 more sources
Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum. [PDF]
J Biol Chem, 2013 The ATP-dependent caseinolytic protease, ClpP, is highly conserved in bacteria and in the organelles of different organisms. In cyanobacteria, plant plastids, and the apicoplast of the genus Plasmodium, a noncatalytic paralog of ClpP, termed ClpR, has been identified. ClpRs are found to form heterocomplexes with ClpP resulting in a ClpRP tetradecameric
El Bakkouri M +10 more
europepmc +4 more sources
Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis [PDF]
Nature CommunicationsThe caseinolytic protease (Clp) system has recently emerged as a promising anti-tuberculosis target. The anti-cancer drug bortezomib exhibits potent anti-mycobacterial activity and binds to Mycobacterium tuberculosis (Mtb) Clp protease complexes.
Biao Zhou +21 more
doaj +3 more sources
A Novel Chymotrypsin-like Protease from Trichoderma koningii FFT13 with Efficient Milk-Clotting Activity [PDF]
FoodsProteases, enzymes that catalyze the hydrolysis of peptide bonds in peptides and proteins, have widespread industrial applications, particularly in milk coagulation for cheese production.
Jéssica Alves Nunes +6 more
doaj +2 more sources
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P. [PDF]
J Nat Prod, 2016 Caseinolytic protease P (ClpP) maintains essential roles in bacterial homeostasis. As such, both the inhibition and activation of this enzyme result in bactericidal activity, making ClpP a promising target for antibacterial drug development. Herein, we report the results of a fluorescence-based screen of ∼450 structurally diverse fungal and bacterial ...
Lavey NP +3 more
europepmc +4 more sources
Antibodies directed against bacterial antigens in sera of Polish patients with primary biliary cholangitis [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundPrimary biliary cholangitis (PBC) is a cholestatic, autoimmune liver disease with the presence of characteristic autoantibodies. The aim of the work was to determine the level of antibodies directed against bacterial antigens: Chlamydia ...
Alicja Bauer, Andrzej Habior
doaj +2 more sources
From Beer to Cheese: Characterization of Caseinolytic and Milk-Clotting Activities of Proteases Derived from Brewer’s Spent Grain (BSG) [PDF]
FoodsThis study explores the extraction and characterization of proteolytic enzymes from brewer’s spent grain (BSG) and their potential as sustainable coagulants in the dairy industry.
Maximiliano M. Villegas +6 more
doaj +2 more sources
Acyldepsipeptide Probes Facilitate Specific Detection of Caseinolytic Protease P Independent of Its Oligomeric and Activity State [PDF]
ChemBioChem, 2020 Heike Brötz-Oesterhelt +2 more
exaly +2 more sources