Results 21 to 30 of about 4,619 (182)

Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P. [PDF]

Am J Obstet Gynecol, 2010
The objective of the study was to assess antibodies against Chlamydia trachomatis heat shock proteins (HSP) in patients with tubal factor infertility (TFI), infertility controls (IFC), and fertile controls (FC). HSPs assist organisms in surviving caustic environments such as heat.Twenty-one TFI, 15 IFC, and 29 FC patients were enrolled after ...
Rodgers AK, Wang J, Zhang Y, Holden A, Berryhill B, Budrys NM, Schenken RS, Zhong G.   +7 more
europepmc   +6 more sources

The structure of caseinolytic protease subunit ClpP2 reveals a functional model of the caseinolytic protease system from Chlamydia trachomatis. [PDF]

J Biol Chem, 2023
Chlamydia trachomatis (ct) is the most reported bacterial sexually transmitted infection worldwide and the leading cause of preventable blindness. Caseinolytic proteases (ClpP) from pathogenic bacteria are attractive antibiotic targets, particularly for bacterial species that form persister colonies with phenotypic resistance against common antibiotics.
Azadmanesh J, Seleem MA, Struble L, Wood NA, Fisher DJ, Lovelace JJ, Artigues A, Fenton AW, Borgstahl GEO, Ouellette SP, Conda-Sheridan M.   +10 more
europepmc   +3 more sources

Technical data on the inhibition properties of some medicinal plant extracts towards caseinolytic protease proteolytic subunit of Plasmodium knowlesi [PDF]

Data in Brief, 2021
Proteolytic subunit of the caseinolytic protease system of Plasmodium knowlesi (Pk-ClpP; EC 3.4.21.92) is considered a viable target for antimalarial drug development to eradicate P.
Raimalynah Abd Razak, Meiny Suzery, Rafida Razali, Zarina Amin, Ruzaidi Azli Mohd Mokhtar, Ping Chin Lee, Cahyo Budiman   +6 more
doaj   +2 more sources

Hinokiflavone Attenuates the Virulence of Methicillin-Resistant Staphylococcus aureus by Targeting Caseinolytic Protease P. [PDF]

Antimicrob Agents Chemother, 2022
Drug-resistant bacteria was the third leading cause of death worldwide in 2019, which sounds like a cautionary note for global public health. Therefore, developing novel strategies to combat Methicillin-resistant Staphylococcus aureus (MRSA) infections is the need of the hour.
Kong X, Wang B, Chen X, Wang L, Wang X, Hou J, Wei L, Sui L, Zhang C, Guan J, Luan Y, Wang W, Song W, Zhao Y.   +13 more
europepmc   +3 more sources

Catalytic Properties of Caseinolytic Protease Subunit of Plasmodium knowlesi and Its Inhibition by a Member of δ-Lactone, Hyptolide [PDF]

Molecules, 2022
The caseinolytic protease (Clp) system plays an essential role in the protein homeostasis of the malaria parasite, particularly at the stage of apicoplast development. The inhibition of this protein is known to have a lethal effect on the parasite and is
Cahyo Budiman, Raimalynah Abd Razak, Angelesa Runin Anak Unggit, Rafida Razali, Meiny Suzery, Ruzaidi Azli Mohd Mokhtar, Ping-Chin Lee, Didik Huswo Utomo   +7 more
doaj   +2 more sources

Mutations in ClpC1 or ClpX subunit of caseinolytic protease confer resistance to ilamycins in mycobacteria [PDF]

Communications Biology
The mycobacterial caseinolytic protease (Clp) system has been recognized as a promising therapeutic target. In this study, we identify two novel ilamycin analogs, ilamycin E (ILE) and ilamycin F (ILF), both targeting the ClpC1 component of the ClpC1P1P2 ...
Yamin Gao, Cuiting Fang, Biao Zhou, H. M. Adnan Hameed, Changli Sun, Xirong Tian, Jing He, Xingli Han, Han Zhang, Jun Li, Jianhua Ju, Xinwen Chen, Nanshan Zhong, Junying Ma, Xiaoli Xiong, Tianyu Zhang   +15 more
doaj   +2 more sources

An antibiotic, heavy metal resistant and halotolerant Bacillus cereus SIU1 and its thermoalkaline protease [PDF]

Microbial Cell Factories, 2010
Background Many workers have reported halotolerant bacteria from saline conditions capable of protease production. However, antibiotic resistance and heavy metal tolerance pattern of such organisms is not documented very well.
Vikram Surendra, Jain Rakesh K, Tripathi Vinayak R, Singh Sanjay K, Garg Satyendra K   +4 more
doaj   +3 more sources

Caseinolytic proteases of Lactobacillus and Lactococcus strains isolated from fermented dairy products

Mljekarstvo, 2022
Proteases of Lactobacillus and Lactococcus strains catalyze casein degradation in fermented dairy products, which can result in the production of bioactive peptides.
Jasna Novak, Andreja Leboš Pavunc, Katarina Butorac, Martina Banić, Nina Čuljak, Helena Rak, Marina Blažević, Ana-Marija Iveljić, Jagoda Šušković, Blaženka Kos   +9 more
doaj   +6 more sources

Structural and mechanistic insights into caseinolytic protease inhibition for antimicrobial development against Pseudomonas plecoglossicida. [PDF]

PLoS Pathogens
The caseinolytic protease (ClpP) is an emerging antibacterial target. Pseudomonas plecoglossicida (Pp), a pathogen causing visceral white spot disease in Larimichthys crocea, encodes two ClpP paralogs, PpClpP1 and PpClpP2.
Jingjie Chen, Ping Zhang, Hongxin Guan, Bing Gong, Xiaoding Li, Zekai Li, Fan Li, Biao Zhou, Xuemin Chen, Xinhua Chen, Songying Ouyang, Yong-An Zhang   +11 more
doaj   +2 more sources

Production, Purification, and Biochemical Characterization of a Novel ATP-Dependent Caseinolytic Protease from the Marine Bacterium Cobetia amphilecti KMM 296 [PDF]

Microorganisms
A novel caseinolytic protease (ClpP) of the S14 family from Cobetia amphilecti KMM 296 (CamClpP), comprising 206 amino acids, with a calculated molecular weight of 22.66 kDa and a pI of 4.88, was expressed in Escherichia coli cells to verify the ...
Yulia Noskova, Olga Nedashkovskaya, Larissa Balabanova   +2 more
doaj   +2 more sources