Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated With Pyrazinamide Resistance in Mycobacterium tuberculosis. [PDF]
Antimicrobial Agents and Chemotherapy, 2017 ABSTRACT Previously, we showed that mutations in Mycobacterium tuberculosis panD , involved in coenzyme A biosynthesis, cause resistance against pyrazinoic acid, the bioactive component of the prodrug pyrazinamide.
Pooja Gopal, Thomas Dick, Michelle Yee
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Cell Reports, 2017 Summary: The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective.
Anat Florentin +7 more
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Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA. [PDF]
PLoS ONE, 2008 Exported proteases of Helicobacter pylori (H. pylori) are potentially involved in pathogen-associated disorders leading to gastric inflammation and neoplasia. By comprehensive sequence screening of the H. pylori proteome for predicted secreted proteases,
Martin Löwer +6 more
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Purification of the Caseinolytic protease ClpP.
, 2022 The caseinolytic protease P (ClpP) is an essential protein for bacteria and bacterial derived organelles. It belongs to the AAA+ family of proteases and has proteolytic activity, thereby, it plays an important role in protein digestion.
Pedrós Manzanares, Laura +1 more
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Association of Tubal Factor Infertility With Elevated Antibodies to Chlamydia trachomatis Caseinolytic Protease P [PDF]
American Journal of Obstetrics and Gynecology, 2010 The objective of the study was to assess antibodies against Chlamydia trachomatis heat shock proteins (HSP) in patients with tubal factor infertility (TFI), infertility controls (IFC), and fertile controls (FC). HSPs assist organisms in surviving caustic environments such as heat.Twenty-one TFI, 15 IFC, and 29 FC patients were enrolled after ...
Guangming Zhong, Robert S Schenken
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Mljekarstvo, 2022 Proteases of Lactobacillus and Lactococcus strains catalyze casein degradation in fermented dairy products, which can result in the production of bioactive peptides.
Jasna Novak +9 more
doaj +6 more sources
A Novel Chymotrypsin-like Protease from Trichoderma koningii FFT13 with Efficient Milk-Clotting Activity [PDF]
FoodsProteases, enzymes that catalyze the hydrolysis of peptide bonds in peptides and proteins, have widespread industrial applications, particularly in milk coagulation for cheese production.
Jéssica Alves Nunes +6 more
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Components of the Clp complex are required for sporangium formation and dehiscence in Actinoplanes missouriensis [PDF]
Journal of BacteriologyThe actinomycete Actinoplanes missouriensis forms terminal sporangia that contain a few hundred spores. When immersed in water, the sporangium opens to release spores, which start swimming using flagella, via a process referred to as sporangium ...
Ryota Suzuki +4 more
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Novel Fibrinolytic Protease Producing Streptomyces radiopugnans VITSD8 from Marine Sponges
Marine Drugs, 2019 Fibrinolytic enzymes have received more attention due to their medicinal potential for thrombolytic diseases. The aim of this study is to characterize the in vitro fibrinolytic nature of purified protease producing Streptomyces radiopugnans VITSD8 from ...
Dhamodharan D +3 more
doaj +2 more sources
Acyldepsipeptide Probes Facilitate Specific Detection of Caseinolytic Protease P Independent of Its Oligomeric and Activity State [PDF]
ChemBioChem, 2020 Heike Brötz-Oesterhelt +2 more
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