Effects of ClpP protease on biofilm formation of Enterococcus faecalis [PDF]
Journal of Applied Oral Science, 2021 Enterococcus faecalis (E. faecalis), one of the main pathogens responsible for refractory periapical periodontitis and nosocomial infections, exhibits markedly higher pathogenicity in biofilms. Objectives Studies have shown that caseinolytic protease P
Ying FENG +4 more
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Bacterial ClpP Protease Is a Potential Target for Methyl Gallate [PDF]
Frontiers in Microbiology, 2021 Methyl gallate (MG) is an effective microbicide with great potential application in the integrated management of plant diseases and an important potential drug for clinical application. However, its target remains unknown.
Xiaogang Wu, Gao-Qing Yuan
exaly +7 more sources
Mitochondrial Protease ClpP: Cancer Marker and Drug Target
PharmaceuticalsBackground: The human mitochondrial ClpP is a serine protease located in the mitochondrial matrix responsible for degrading short lived regulatory proteins as well as misfolded or damaged proteins, thereby maintaining cellular homeostasis.
Savina Ferorelli +2 more
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Cellular functions of the ClpP protease impacting bacterial virulence [PDF]
Frontiers in Molecular Biosciences, 2022 Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent ...
Mazen E. Aljghami +5 more
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Pharmacological inhibition of CLPP stabilizes LETMD1 to boost thermogenesis and alleviate obesity [PDF]
AdipocyteObesity poses a severe global health burden, and activating adipose thermogenesis offers a promising therapeutic avenue. However, the contribution of mitochondrial proteostasis to thermogenic regulation remains elusive.
Huiwen Yuan +4 more
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Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site [PDF]
Nature CommunicationsClpP protease maintains proteostasis in human mitochondria and is overexpressed in cancers such as acute myeloid leukemia (AML). While activators such as dordaviprone (ONC201) have reached the clinic, the development of ClpP inhibitors has been hampered ...
Monica M. Goncalves +34 more
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Design, Synthesis, and Structure-Activity Relationships of Novel Piperidine-Fused Imidazolone ClpP Activators as Potential Anti-Cancer Agents [PDF]
MoleculesCaseinolytic protease P (ClpP) is essential for maintaining mitochondrial protein homeostasis, and its activation has emerged as an attractive cancer therapeutic strategy. However, ONC201 is currently the only approved ClpP activator, and its low potency
Shanshan Chen +8 more
doaj +2 more sources
Recent Structural Insights Into the Mechanism of ClpP Protease Regulation by AAA+ Chaperones and Small Molecules [PDF]
Journal of Biological Chemistry, 2022 Walid A Houry, Mark F Mabanglo
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CLPP loss confers sex-specific protection from renal ischemia reperfusion injury [PDF]
Redox BiologyRenal ischemia-reperfusion injury (IRI) is initiated by a burst of mitochondrial reactive oxygen species generated when ischemia-accumulated succinate is rapidly oxidised upon reperfusion, driving reverse electron transport and triggering lipid ...
Lea Isermann +16 more
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Repurposing Birabresib to target Gram‑positive bacteria [PDF]
npj Antimicrobials and ResistanceThe threat of antibiotic-resistant bacteria is rapidly escalating, creating an urgent need for new types of antimicrobials. Although most antibiotics act by disrupting essential cellular processes, such as cell division, replication, transcription, and ...
Hazera Khatun Koly +3 more
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