Bacterial ClpP Protease Is a Potential Target for Methyl Gallate [PDF]
Frontiers in Microbiology, 2021 Methyl gallate (MG) is an effective microbicide with great potential application in the integrated management of plant diseases and an important potential drug for clinical application. However, its target remains unknown.
Dehong Zheng +4 more
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Cellular functions of the ClpP protease impacting bacterial virulence [PDF]
Frontiers in Molecular Biosciences, 2022 Proteostasis mechanisms significantly contribute to the sculpting of the proteomes of all living organisms. ClpXP is a central AAA+ chaperone-protease complex present in both prokaryotes and eukaryotes that facilitates the unfolding and subsequent ...
Mazen E. Aljghami +5 more
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Effects of ClpP protease on biofilm formation of Enterococcus faecalis [PDF]
Journal of Applied Oral Science, 2021 Enterococcus faecalis (E. faecalis), one of the main pathogens responsible for refractory periapical periodontitis and nosocomial infections, exhibits markedly higher pathogenicity in biofilms. Objectives Studies have shown that caseinolytic protease P
Ying FENG +4 more
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Mitochondrial Protease ClpP: Cancer Marker and Drug Target [PDF]
PharmaceuticalsBackground: The human mitochondrial ClpP is a serine protease located in the mitochondrial matrix responsible for degrading short lived regulatory proteins as well as misfolded or damaged proteins, thereby maintaining cellular homeostasis.
Domenico Armenise +8 more
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Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization [PDF]
Advanced ScienceNatural product biosynthesis is tightly coupled to nitrogen allocation. However, scalable strategies to amplify pathway outputs remain limited. Here, atmospheric and room temperature plasma (ARTP) mutagenesis of Saccharopolyspora spinosa yielded a high ...
Duo Jin +9 more
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ClpP protease modulates bacterial growth, stress response, and bacterial virulence in Brucella abortus [PDF]
Veterinary Research, 2023 The process of intracellular proteolysis through ATP-dependent proteases is a biologically conserved phenomenon. The stress responses and bacterial virulence of various pathogenic bacteria are associated with the ATP-dependent Clp protease. In this study,
Dongjie Sun +11 more
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The ClpP protease homologue is required for the transmission traits and cell division of the pathogen
BMC Microbiology, 2010 Background Legionella pneumophila, the intracellular bacterial pathogen that causes Legionnaires' disease, exhibit characteristic transmission traits such as elevated stress tolerance, shortened length and virulence during the transition from the ...
Zhang Qin-fen +6 more
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Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease models [PDF]
Molecular NeurodegenerationBackground Mitochondrial dysfunction and α-Synuclein (αSyn) aggregation are defining features of Parkinson’s disease (PD), yet the mechanistic link between them remains poorly understood.
Di Hu, Xiaoyan Sun, Xin Qi
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The ClpP protease is required for the stress tolerance and biofilm formation in Actinobacillus pleuropneumoniae. [PDF]
PLoS ONE, 2013 In the respiratory tract and lung tissue, a balanced physiological response is essential for Actinobacillus pleuropneumoniae to survive various types of challenges.
Fang Xie +5 more
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Self-resistance mechanism to acyldepsipeptide antibiotics in the Streptomyces producer [PDF]
mBioClp proteases are ubiquitous in bacteria and play an important role in regulatory proteolysis and in maintaining protein homeostasis within the bacterial cell. They consist of a tetradecameric, proteolytic ClpP core and associated AAA+ Clp-ATPases.
Dhana Thomy +6 more
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